Cntnap2<sup>em1Sage</sup> (contactin associated protein-like 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Cntnap2em1Sage (contactin associated protein-like 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Cntnap2em1Sage
Name: contactin associated protein-like 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
RGD ID: 11568647
Description: The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Met into Sprague Dawley embryos. The resulting mutation was a 5-bp deletion in exon 6 of Cntnap2. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot.
ASSOCIATED WITH abnormal auditory brainstem response; abnormal habituation; abnormal prepulse inhibition; ASSOCIATED WITH autism spectrum disorder; epilepsy
Type: allele  of Cntnap2  
Previously known as: Cntnap2tm1Sage; Cntnap2^[em1Sage]; Cntnap2em1Sage
Is Marker For: Strains:   SD-Cntnap2em1Sage  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders. Scott KE, etal., J Neurosci. 2018 Oct 3;38(40):8588-8604. doi: 10.1523/JNEUROSCI.0759-18.2018. Epub 2018 Aug 20.
2. Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology. Thomas AM, etal., Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw026.

Genomics


Related Rat Strains
The following Strains have been annotated to Cntnap2em1Sage
SD-Cntnap2em1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information