Ttn<sup>em2Sage</sup> (Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs) - Rat Genome Database

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Gene: Ttnem2Sage (Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Ttnem2Sage
Name: Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
RGD ID: 11565827
Description: The zinc-finger nuclease mediated genome editing system created a deletion of exons 2-6 (5,286-bp deletion, coordinates 2,323-7,608) to introduce a frameshift (Rnor_5.0).
ASSOCIATED WITH abnormal cardiac muscle contractility; decreased cardiac muscle relaxation; decreased cardiac stroke volume
Type: allele  of Ttn  
Previously known as: Titin; zinc finger nuclease induced mutant2,Sigma Advanced Genetic Engineering Labs; Ttn^[em2Sage]; Ttnem2Sage; TTNtvZ
Is Marker For: Strains:   F344-Ttnem2Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Titin-truncating variants affect heart function in disease cohorts and the general population. Schafer S, etal., Nat Genet. 2016 Nov 21. doi: 10.1038/ng.3719.

Genomics


Related Rat Strains
The following Strains have been annotated to Ttnem2Sage


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-28 Ttnem2Sage  Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs  Ttnem2Sage  Titin; zinc finger nuclease induced mutant2,Sigma Advanced Genetic Engineering Labs  Name changed 629549 APPROVED