Shc1<sup>em4Mcwi</sup> (SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Shc1em4Mcwi (SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Shc1em4Mcwi
Name: SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin
RGD ID: 11553913
Description: This allele was made by ZFN system. The resulting mutation is a 13-bp deletion in Exon 2 of the Shc1 gene.
ASSOCIATED WITH decreased urine albumin level; glomerulosclerosis; increased vasoconstriction; ASSOCIATED WITH Albuminuria; glomerulosclerosis
Type: allele  of Shc1  
Previously known as: p66Shcem4Mcwi; p66Shcem4Mcwi; Shc1^[em4Mcwi]; Shc1em4Mcwi
Is Marker For: Strains:   SS-Shc1em4Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

Genomics


Related Rat Strains
The following Strains have been annotated to Shc1em4Mcwi
SS-Shc1em4Mcwi    


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-17 Shc1em4Mcwi  SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin  p66Shcem4Mcwi  SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin  Symbol changed 629549 APPROVED