Gene: Trh (thyrotropin releasing hormone) Mus musculus
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Symbol:
Trh
Name:
thyrotropin releasing hormone
Description:
Predicted to have thyrotropin-releasing hormone activity. Involved in adult walking behavior. Predicted to localize to the nucleus; plasma membrane; and secretory granule. Is expressed in several structures, including embryo endoderm; gut; neural ectoderm; renal vasculature; and trigeminal ganglion. Orthologous to human TRH (thyrotropin releasing hormone).
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
AI324969; AL022609; pro-thyrotropin-releasing hormone; Pro-TRH; prothyroliberin; protirelin; thyrotropin-releasing factor; Trf; TSH-releasing factor
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TRH (thyrotropin releasing hormone) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Trh (thyrotropin releasing hormone) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Trh (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TRH (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TRH (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Trh (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TRH (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
TRH (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Trh (thyrotropin releasing hormone) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Trh (thyrotropin releasing hormone)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
TRH (thyrotropin releasing hormone)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
trh (thyrotropin-releasing hormone)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 6 92,242,061 - 92,244,650 (-) Ensembl GRCm38 6 92,242,061 - 92,244,650 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 92,192,056 - 92,194,642 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 92,207,565 - 92,209,391 (-) NCBI mm8 Celera 6 94,137,672 - 94,140,258 (-) NCBI Celera Cytogenetic Map 6 D1 NCBI cM Map 6 41.03 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Developmental Disabilities ISO RGD:69154 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:25741868
Imported Annotations - CTD
acute myeloid leukemia ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18206229 amnestic disorder ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:7562510 more ... Bradycardia ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:6350720 , PMID:6813757 Cardiac Arrhythmias ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:6813757 Catalepsy ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:2547386 endometriosis ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21063030 hypertension ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:6350720 Hypothermia ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:6350720 learning disability ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:8405091 narcolepsy ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2845442 Pain ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:6409194 Post-Head Injury Coma ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:8690305 respiratory failure ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:1305443 , PMID:1833029 stereotypic movement disorder ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:8736133 Stupor ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:416961 , PMID:8690305 Tachycardia ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:6350720 Tremor ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:103733 , PMID:416961 Unconsciousness ISO RGD:69154 11554173 CTD Direct Evidence: therapeutic CTD PMID:6281507 visual epilepsy ISO RGD:69154 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:10443546 , PMID:15781040 Imported Annotations - OMIM
Thyrotropin-Releasing Hormone Deficiency ISO RGD:69154 7240710 OMIM
(+)-pilocarpine increases expression ISO RGD:3903 6480464 Pilocarpine results in increased expression of TRH mRNA CTD PMID:10443546 , PMID:15781040 1,3,5-trinitro-1,3,5-triazinane increases expression ISO RGD:3903 6480464 cyclonite results in increased expression of TRH mRNA CTD PMID:25559034 17beta-estradiol multiple interactions ISO RGD:3903 6480464 Estradiol inhibits the reaction [TRH protein results in increased secretion of PRL protein] more ... CTD PMID:16570238 , PMID:29305326 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:69154 6480464 Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] CTD PMID:7851873 3,7-dihydropurine-6-thione increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of TRH mRNA CTD PMID:30951980 5-azacytidine decreases expression ISO RGD:69154 6480464 Azacitidine results in decreased expression of TRH mRNA CTD PMID:19194470 6-propyl-2-thiouracil increases expression ISO RGD:3903 6480464 Propylthiouracil results in increased expression of TRH mRNA CTD PMID:24780913 adinazolam multiple interactions ISO RGD:3903 6480464 adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of TRH mRNA CTD PMID:16788091 all-trans-retinoic acid increases expression ISO RGD:3903 6480464 Tretinoin results in increased expression of TRH mRNA CTD PMID:20488242 alprazolam multiple interactions ISO RGD:3903 6480464 Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 amitriptyline multiple interactions ISO RGD:69154 6480464 Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 ammonium chloride affects expression ISO RGD:3903 6480464 Ammonium Chloride affects the expression of TRH mRNA CTD PMID:16483693 benzo[e]pyrene increases methylation ISO RGD:69154 6480464 benzo(e)pyrene results in increased methylation of TRH exon CTD PMID:30157460 bis(2-ethylhexyl) phthalate increases expression ISO RGD:3903 6480464 Diethylhexyl Phthalate results in increased expression of TRH mRNA CTD PMID:28871463 , PMID:30078309 bisphenol A decreases expression ISO RGD:3903 6480464 bisphenol A results in decreased expression of TRH mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:3903 6480464 bisphenol A inhibits the reaction [TRH protein results in increased secretion of PRL protein], bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein] CTD PMID:29305326 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TRH mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:3903 6480464 bisphenol A results in increased expression of TRH mRNA CTD PMID:30816183 bisphenol A increases methylation ISO RGD:3903 6480464 bisphenol A results in increased methylation of TRH gene CTD PMID:28505145 bisphenol F affects expression EXP 6480464 bisphenol F affects the expression of TRH mRNA CTD PMID:30951980 carbon dioxide increases response to substance ISO RGD:69154 6480464 TRH protein results in increased susceptibility to Carbon Dioxide CTD PMID:8957205 chlordiazepoxide multiple interactions ISO RGD:3903 6480464 Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 copper atom decreases secretion EXP 6480464 Copper deficiency results in decreased secretion of TRH protein modified form CTD PMID:19815072 copper(0) decreases secretion EXP 6480464 Copper deficiency results in decreased secretion of TRH protein modified form CTD PMID:19815072 decabromodiphenyl ether increases secretion ISO RGD:3903 6480464 decabromobiphenyl ether results in increased secretion of TRH protein CTD PMID:30844666 dexamethasone multiple interactions ISO RGD:3903 6480464 Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] CTD PMID:9681491 dexamethasone increases expression ISO RGD:3903 6480464 Dexamethasone results in increased expression of TRH protein CTD PMID:9681491 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of TRH mRNA CTD PMID:29950665 diazepam multiple interactions ISO RGD:3903 6480464 Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 disodium selenite decreases expression ISO RGD:69154 6480464 Sodium Selenite results in decreased expression of TRH mRNA CTD PMID:18175754 disulfiram multiple interactions ISO RGD:3903 6480464 Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] CTD PMID:9681491 disulfiram increases expression ISO RGD:3903 6480464 Disulfiram results in increased expression of TRH mRNA alternative form CTD PMID:9681491 disulfiram decreases expression ISO RGD:3903 6480464 Disulfiram results in decreased expression of TRH protein CTD PMID:9681491 doxorubicin affects expression ISO RGD:69154 6480464 Doxorubicin affects the expression of TRH mRNA CTD PMID:29803840 erythrosin B multiple interactions ISO RGD:3903 6480464 Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 estazolam multiple interactions ISO RGD:3903 6480464 Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 ethanol increases expression ISO RGD:69154 6480464 Ethanol results in increased expression of TRH mRNA CTD PMID:31059573 flurazepam multiple interactions ISO RGD:3903 6480464 Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 fonofos increases methylation ISO RGD:69154 6480464 Fonofos results in increased methylation of TRH promoter CTD PMID:22847954 kainic acid decreases expression ISO RGD:3903 6480464 Kainic Acid results in decreased expression of TRH mRNA CTD PMID:10443546 kainic acid increases expression ISO RGD:3903 6480464 Kainic Acid results in increased expression of TRH mRNA CTD PMID:10443546 ketamine increases expression ISO RGD:3903 6480464 Ketamine results in increased expression of TRH mRNA CTD PMID:20080153 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of TRH mRNA CTD PMID:15305145 lead(0) affects expression ISO RGD:69154 6480464 Lead affects the expression of TRH mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:69154 6480464 Lead affects the expression of TRH mRNA CTD PMID:28903495 mercaptopurine increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 methapyrilene increases methylation ISO RGD:69154 6480464 Methapyrilene results in increased methylation of TRH exon CTD PMID:30157460 methoxychlor multiple interactions ISO RGD:3903 6480464 TRH protein affects the reaction [Methoxychlor results in increased secretion of PRL protein] CTD PMID:12761465 midazolam multiple interactions ISO RGD:3903 6480464 Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 Monobutylphthalate decreases expression ISO RGD:3903 6480464 monobutyl phthalate results in decreased expression of TRH mRNA CTD PMID:29162477 morphine increases expression EXP 6480464 Morphine results in increased expression of TRH mRNA CTD PMID:21178816 N-methyl-4-phenylpyridinium decreases expression ISO RGD:69154 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TRH mRNA CTD PMID:24810058 octreotide multiple interactions ISO RGD:69154 6480464 Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein] CTD PMID:1518433 okadaic acid multiple interactions ISO RGD:3903 6480464 Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of ACO1 protein], Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of IREB2 protein] CTD PMID:10889193 oxidopamine multiple interactions ISO RGD:3903 6480464 [Levodopa co-treated with Oxidopamine] results in increased expression of TRH mRNA, [Levodopa co-treated with Oxidopamine] results in increased expression of TRH protein CTD PMID:21085660 ozone increases expression ISO RGD:3903 6480464 Ozone results in increased expression of TRH mRNA CTD PMID:28623178 paracetamol decreases expression ISO RGD:69154 6480464 Acetaminophen results in decreased expression of TRH mRNA CTD PMID:26690555 parathion increases methylation ISO RGD:69154 6480464 Parathion results in increased methylation of TRH promoter CTD PMID:22847954 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:3903 6480464 TRH protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IREB2 protein] CTD PMID:10889193 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of ACO1 protein], Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of IREB2 protein] CTD PMID:10889193 progesterone increases expression ISO RGD:3903 6480464 Progesterone results in increased expression of TRH mRNA CTD PMID:21770760 protein kinase inhibitor multiple interactions EXP 6480464 Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of ACO1 protein], Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of IREB2 protein] CTD PMID:10889193 purine-6-thiol increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 resveratrol decreases expression ISO RGD:69154 6480464 resveratrol results in decreased expression of TRH mRNA CTD PMID:23224687 sodium arsenate affects expression EXP 6480464 sodium arsenate affects the expression of TRH mRNA CTD PMID:28813693 sodium arsenite affects methylation ISO RGD:69154 6480464 sodium arsenite affects the methylation of TRH gene CTD PMID:28589171 sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of TRH mRNA CTD PMID:28813693 sodium perchlorate increases expression ISO RGD:3903 6480464 sodium perchlorate results in increased expression of TRH mRNA CTD PMID:29139221 sodium perchlorate decreases expression ISO RGD:3903 6480464 sodium perchlorate results in decreased expression of TRH protein CTD PMID:29139221 streptozocin decreases expression ISO RGD:3903 6480464 Streptozocin results in decreased expression of TRH mRNA CTD PMID:16118471 streptozocin multiple interactions ISO RGD:3903 6480464 TRH protein inhibits the reaction [Streptozocin inhibits the reaction [Blood Glucose results in increased secretion of INS1 protein]] CTD PMID:16118471 sunitinib decreases expression ISO RGD:69154 6480464 Sunitinib results in decreased expression of TRH mRNA CTD PMID:31533062 terbufos increases methylation ISO RGD:69154 6480464 terbufos results in increased methylation of TRH promoter CTD PMID:22847954 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of TRH mRNA CTD PMID:29950665 triazolam multiple interactions ISO RGD:3903 6480464 Triazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 triclosan decreases expression ISO RGD:69154 6480464 Triclosan results in decreased expression of TRH mRNA CTD PMID:30510588 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of TRH mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:69154 6480464 Valproic Acid results in decreased expression of TRH mRNA CTD PMID:23179753 verapamil multiple interactions ISO RGD:69154 6480464 Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] CTD PMID:7851873
Biological Process adult walking behavior IGI MGI:MGI:109482 2290270 (MGI:MGI:83622, PMID:8719807) MGI MGI:MGI:83622 , PMID:8719807 eating behavior ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 eating behavior IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 histamine metabolic process ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 histamine metabolic process IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 hormone-mediated signaling pathway IEA InterPro:IPR008857 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 negative regulation of feeding behavior ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of glutamate secretion ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of glutamate secretion IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of gamma-aminobutyric acid secretion ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of gamma-aminobutyric acid secretion IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of insulin secretion ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of insulin secretion IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 Cellular Component cytoplasm ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 extracellular region IEA InterPro:IPR008857 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 extracellular region IEA UniProtKB-KW:KW-0964 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nucleus ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 plasma membrane ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 secretory granule ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 secretory granule IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function hormone activity IEA UniProtKB-KW:KW-0372 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q9ERT2 2290270 (MGI:MGI:2159489, PMID:11181534) MGI MGI:MGI:2159489 , PMID:11181534 thyrotropin-releasing hormone activity ISO RGD:3903 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 thyrotropin-releasing hormone activity IBA PANTHER:PTN001048877 , RGD:3903 2290270 (PMID:21873635) GO_Central PMID:21873635 thyrotropin-releasing hormone activity ISO EMBL:M12138 2290270 (MGI:MGI:49826, PMID:1323011) MGI MGI:MGI:49826 , PMID:1323011
Gene-Chemical Interaction Annotations
