(+)-pilocarpine increases expression ISO RGD:3903 6480464 Pilocarpine results in increased expression of TRH mRNA CTD PMID:10443546 , PMID:15781040 1,3,5-trinitro-1,3,5-triazinane increases expression ISO RGD:3903 6480464 cyclonite results in increased expression of TRH mRNA CTD PMID:25559034 17beta-estradiol multiple interactions ISO RGD:3903 6480464 Estradiol inhibits the reaction [TRH protein results in increased secretion of PRL protein] more ... CTD PMID:16570238 , PMID:29305326 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:3903 6480464 Tetrachlorodibenzodioxin results in decreased expression of TRH mRNA CTD PMID:32109520 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions ISO RGD:69154 6480464 Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] CTD PMID:7851873 3,7-dihydropurine-6-thione increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis4-hydroxyphenylsulfone results in increased expression of TRH mRNA CTD PMID:30951980 5-azacytidine decreases expression ISO RGD:69154 6480464 Azacitidine results in decreased expression of TRH mRNA CTD PMID:19194470 6-propyl-2-thiouracil increases expression ISO RGD:3903 6480464 Propylthiouracil results in increased expression of TRH mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:69154 6480464 Acrylamide results in decreased expression of TRH mRNA CTD PMID:32763439 adinazolam multiple interactions ISO RGD:3903 6480464 adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of TRH mRNA CTD PMID:16788091 all-trans-retinoic acid increases expression ISO RGD:3903 6480464 Tretinoin results in increased expression of TRH mRNA CTD PMID:20488242 alprazolam multiple interactions ISO RGD:3903 6480464 Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 amitriptyline multiple interactions ISO RGD:69154 6480464 Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 ammonium chloride affects expression ISO RGD:3903 6480464 Ammonium Chloride affects the expression of TRH mRNA CTD PMID:16483693 benzo[a]pyrene affects methylation ISO RGD:69154 6480464 Benzoapyrene affects the methylation of TRH 5' UTR CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:69154 6480464 Benzoapyrene results in decreased methylation of TRH 3' UTR CTD PMID:27901495 benzo[e]pyrene increases methylation ISO RGD:69154 6480464 benzoepyrene results in increased methylation of TRH exon CTD PMID:30157460 bis(2-ethylhexyl) phthalate increases expression ISO RGD:3903 6480464 Diethylhexyl Phthalate results in increased expression of TRH mRNA CTD PMID:28871463 , PMID:30078309 bisphenol A decreases expression ISO RGD:3903 6480464 bisphenol A results in decreased expression of TRH mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:3903 6480464 bisphenol A inhibits the reaction [TRH protein results in increased secretion of PRL protein], bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein] CTD PMID:29305326 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TRH mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:3903 6480464 bisphenol A results in increased expression of TRH mRNA CTD PMID:30816183 bisphenol A increases methylation ISO RGD:3903 6480464 bisphenol A results in increased methylation of TRH gene CTD PMID:28505145 bisphenol F affects expression EXP 6480464 bisphenol F affects the expression of TRH mRNA CTD PMID:30951980 carbon dioxide increases response to substance ISO RGD:69154 6480464 TRH protein results in increased susceptibility to Carbon Dioxide CTD PMID:8957205 chlordiazepoxide multiple interactions ISO RGD:3903 6480464 Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 copper atom decreases secretion EXP 6480464 Copper deficiency results in decreased secretion of TRH protein modified form CTD PMID:19815072 copper(0) decreases secretion EXP 6480464 Copper deficiency results in decreased secretion of TRH protein modified form CTD PMID:19815072 decabromodiphenyl ether increases secretion ISO RGD:3903 6480464 decabromobiphenyl ether results in increased secretion of TRH protein CTD PMID:30844666 dexamethasone multiple interactions ISO RGD:3903 6480464 Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] CTD PMID:9681491 dexamethasone increases expression ISO RGD:3903 6480464 Dexamethasone results in increased expression of TRH protein CTD PMID:9681491 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of TRH mRNA CTD PMID:29950665 diazepam multiple interactions ISO RGD:3903 6480464 Diazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 disodium selenite decreases expression ISO RGD:69154 6480464 Sodium Selenite results in decreased expression of TRH mRNA CTD PMID:18175754 disulfiram multiple interactions ISO RGD:3903 6480464 Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein] CTD PMID:9681491 disulfiram increases expression ISO RGD:3903 6480464 Disulfiram results in increased expression of TRH mRNA alternative form CTD PMID:9681491 disulfiram decreases expression ISO RGD:3903 6480464 Disulfiram results in decreased expression of TRH protein CTD PMID:9681491 doxorubicin affects expression ISO RGD:69154 6480464 Doxorubicin affects the expression of TRH mRNA CTD PMID:29803840 erythrosin B multiple interactions ISO RGD:3903 6480464 Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 estazolam multiple interactions ISO RGD:3903 6480464 Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 ethanol increases expression ISO RGD:69154 6480464 Ethanol results in increased expression of TRH mRNA CTD PMID:31059573 fenvalerate increases expression ISO RGD:3903 6480464 fenvalerate results in increased expression of TRH mRNA CTD PMID:30307764 flurazepam multiple interactions ISO RGD:3903 6480464 Flurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 fonofos increases methylation ISO RGD:69154 6480464 Fonofos results in increased methylation of TRH promoter CTD PMID:22847954 genistein decreases expression EXP 6480464 Genistein results in decreased expression of TRH mRNA CTD PMID:32186404 kainic acid decreases expression ISO RGD:3903 6480464 Kainic Acid results in decreased expression of TRH mRNA CTD PMID:10443546 kainic acid increases expression ISO RGD:3903 6480464 Kainic Acid results in increased expression of TRH mRNA CTD PMID:10443546 ketamine increases expression ISO RGD:3903 6480464 Ketamine results in increased expression of TRH mRNA CTD PMID:20080153 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of TRH mRNA CTD PMID:15305145 lead(0) affects expression ISO RGD:69154 6480464 Lead affects the expression of TRH mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:69154 6480464 Lead affects the expression of TRH mRNA CTD PMID:28903495 mercaptopurine increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 methapyrilene increases methylation ISO RGD:69154 6480464 Methapyrilene results in increased methylation of TRH exon CTD PMID:30157460 methoxychlor multiple interactions ISO RGD:3903 6480464 TRH protein affects the reaction [Methoxychlor results in increased secretion of PRL protein] CTD PMID:12761465 midazolam multiple interactions ISO RGD:3903 6480464 Midazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 Monobutylphthalate decreases expression ISO RGD:3903 6480464 monobutyl phthalate results in decreased expression of TRH mRNA CTD PMID:29162477 morphine increases expression EXP 6480464 Morphine results in increased expression of TRH mRNA CTD PMID:21178816 N-methyl-4-phenylpyridinium decreases expression ISO RGD:69154 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of TRH mRNA CTD PMID:24810058 octreotide multiple interactions ISO RGD:69154 6480464 Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein] CTD PMID:1518433 okadaic acid multiple interactions ISO RGD:3903 6480464 Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of ACO1 protein], Okadaic Acid inhibits the reaction [TRH protein results in decreased activity of IREB2 protein] CTD PMID:10889193 oxidopamine multiple interactions ISO RGD:3903 6480464 [Levodopa co-treated with Oxidopamine] results in increased expression of TRH mRNA, [Levodopa co-treated with Oxidopamine] results in increased expression of TRH protein CTD PMID:21085660 ozone increases expression ISO RGD:3903 6480464 Ozone results in increased expression of TRH mRNA CTD PMID:28623178 paracetamol decreases expression ISO RGD:69154 6480464 Acetaminophen results in decreased expression of TRH mRNA CTD PMID:26690555 parathion increases methylation ISO RGD:69154 6480464 Parathion results in increased methylation of TRH promoter CTD PMID:22847954 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:3903 6480464 TRH protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IREB2 protein] CTD PMID:10889193 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of ACO1 protein], Tetradecanoylphorbol Acetate inhibits the reaction [TRH protein results in increased activity of IREB2 protein] CTD PMID:10889193 progesterone increases expression ISO RGD:3903 6480464 Progesterone results in increased expression of TRH mRNA CTD PMID:21770760 protein kinase inhibitor multiple interactions EXP 6480464 Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of ACO1 protein], Protein Kinase Inhibitors inhibits the reaction [TRH protein results in increased activity of IREB2 protein] CTD PMID:10889193 purine-6-thiol increases expression ISO RGD:3903 6480464 Mercaptopurine results in increased expression of TRH mRNA CTD PMID:23358152 resveratrol decreases expression ISO RGD:69154 6480464 resveratrol results in decreased expression of TRH mRNA CTD PMID:23224687 sodium arsenate affects expression EXP 6480464 sodium arsenate affects the expression of TRH mRNA CTD PMID:28813693 sodium arsenite affects methylation ISO RGD:69154 6480464 sodium arsenite affects the methylation of TRH gene CTD PMID:28589171 sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of TRH mRNA CTD PMID:28813693 sodium perchlorate increases expression ISO RGD:3903 6480464 sodium perchlorate results in increased expression of TRH mRNA CTD PMID:29139221 sodium perchlorate decreases expression ISO RGD:3903 6480464 sodium perchlorate results in decreased expression of TRH protein CTD PMID:29139221 streptozocin decreases expression ISO RGD:3903 6480464 Streptozocin results in decreased expression of TRH mRNA CTD PMID:16118471 streptozocin multiple interactions ISO RGD:3903 6480464 TRH protein inhibits the reaction [Streptozocin inhibits the reaction [Blood Glucose results in increased secretion of INS1 protein]] CTD PMID:16118471 sunitinib decreases expression ISO RGD:69154 6480464 Sunitinib results in decreased expression of TRH mRNA CTD PMID:31533062 terbufos increases methylation ISO RGD:69154 6480464 terbufos results in increased methylation of TRH promoter CTD PMID:22847954 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] affects the expression of TRH mRNA CTD PMID:29950665 triazolam multiple interactions ISO RGD:3903 6480464 Triazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 triclosan decreases expression ISO RGD:69154 6480464 Triclosan results in decreased expression of TRH mRNA CTD PMID:30510588 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of TRH mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:69154 6480464 Valproic Acid results in decreased expression of TRH mRNA CTD PMID:23179753 verapamil multiple interactions ISO RGD:69154 6480464 Verapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein] CTD PMID:7851873
