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Gene: Tle4 (transducin-like enhancer of split 4) Mus musculus
Symbol: Tle4
Name: transducin-like enhancer of split 4
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; repressing transcription factor binding activity; and transcription corepressor activity. Involved in Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Localizes to the nucleus. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system ganglion; sensory organ; and trunk mesenchyme. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730411M05Rik; AA792082; B lymphocyte gene 1; Bce-1; Bce1; ESTM13; ESTM14; grg-4; Grg4; groucho-related protein 4; transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4; X83332; X83333
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1914,448,150 - 14,598,051 (-)Ensembl
GRCm381914,448,072 - 14,598,183 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371914,522,562 - 14,672,473 (-)NCBIGRCm37mm9NCBIm37
MGSCv361914,515,091 - 14,665,002 (-)NCBImm8
Celera1915,104,678 - 15,255,003 (-)NCBICelera
Cytogenetic Map19 ANCBI
cM Map199.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tle4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11422
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.