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Gene: Tg (thyroglobulin) Mus musculus
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Symbol: Tg
Name: thyroglobulin
Description: Exhibits identical protein binding activity. Involved in iodide transport; regulation of myelination; and thyroid hormone generation. Localizes to extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Orthologous to human TG (thyroglobulin); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; INTERACTS WITH benzo[a]pyrene; buta-1,3-diene; chlorpyrifos.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cog; congenital goiter; MGC117699; Tgn
Orthologs:
Homo sapiens (human) : TG (thyroglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tg (thyroglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tg (thyroglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : TG (thyroglobulin)
Canis lupus familiaris (dog) : TG (thyroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tg (thyroglobulin)
Sus scrofa (pig) : TG (thyroglobulin)
Chlorocebus sabaeus (African green monkey) : TG (thyroglobulin)
Heterocephalus glaber (naked mole-rat) : Tg (thyroglobulin)
more info ...
Is Marker For: QTLs:   Fob3_m  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1566,670,753 - 66,850,721 (+)EnsemblGRCm38mm10GRCm38
GRCm381566,670,754 - 66,850,721 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371566,502,332 - 66,682,283 (+)NCBIGRCm37mm9NCBIm37
MGSCv361566,500,461 - 66,680,276 (+)NCBImm8
Celera1568,203,057 - 68,383,403 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tg
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11408
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.