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Gene: Tg (thyroglobulin) Mus musculus
Symbol: Tg
Name: thyroglobulin
Description: Exhibits identical protein binding activity. Involved in iodide transport; regulation of myelination; and thyroid hormone generation. Localizes to extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Orthologous to human TG (thyroglobulin); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; INTERACTS WITH benzo[a]pyrene; buta-1,3-diene; chlorpyrifos.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cog; congenital goiter; MGC117699; Tgn
Homo sapiens (human) : TG (thyroglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tg (thyroglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tg (thyroglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : TG (thyroglobulin)
Canis lupus familiaris (dog) : TG (thyroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tg (thyroglobulin)
Sus scrofa (pig) : TG (thyroglobulin)
Chlorocebus sabaeus (African green monkey) : TG (thyroglobulin)
Heterocephalus glaber (naked mole-rat) : Tg (thyroglobulin)
more info ...
Is Marker For: QTLs:   Fob3_m  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1566,670,753 - 66,850,721 (+)EnsemblGRCm38mm10GRCm38
GRCm381566,670,754 - 66,850,721 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371566,502,332 - 66,682,283 (+)NCBIGRCm37mm9NCBIm37
MGSCv361566,500,461 - 66,680,276 (+)NCBImm8
Celera1568,203,057 - 68,383,403 (+)NCBICelera
Cytogenetic Map15D2NCBI
cM Map1529.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tg
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11408
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.