Ighg3 (Immunoglobulin heavy constant gamma 3) - Rat Genome Database

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Gene: Ighg3 (Immunoglobulin heavy constant gamma 3) Mus musculus
Analyze
Symbol: Ighg3
Name: Immunoglobulin heavy constant gamma 3
RGD ID: 11317091
MGI Page MGI
Description: Enables immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in extracellular space. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)).
Type: gene (Ensembl: IG_C_gene)
RefSeq Status: VALIDATED
Previously known as: AI3240; IgG; IgG3
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,321,062 - 113,324,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,319,844 - 113,324,852 (-)EnsemblGRCm39 Ensembl
GRCm3812113,357,442 - 113,361,232 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,356,224 - 113,361,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,595,653 - 114,599,443 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,807,383 - 113,809,043 (-)NCBIMGSCv36mm8
Celera12114,545,281 - 114,771,577 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:6092053   PMID:6314258   PMID:7734427   PMID:9707605   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15608191   PMID:16141072  
PMID:16141073   PMID:17330941   PMID:18946502   PMID:20031218   PMID:21873635   PMID:23024299   PMID:25798939   PMID:25896912   PMID:26025364   PMID:28710441   PMID:31433298   PMID:35651614  


Genomics

Comparative Map Data
Ighg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,321,062 - 113,324,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,319,844 - 113,324,852 (-)EnsemblGRCm39 Ensembl
GRCm3812113,357,442 - 113,361,232 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,356,224 - 113,361,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,595,653 - 114,599,443 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,807,383 - 113,809,043 (-)NCBIMGSCv36mm8
Celera12114,545,281 - 114,771,577 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
IGHG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,765,914 - 105,771,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,764,503 - 105,771,405 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,232,251 - 106,237,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,303,296 - 105,308,787 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,162,566 - 86,168,057 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,364,823 - 86,370,301 (-)NCBIHuRef
CHM1_114106,107,639 - 106,108,359 (-)NCBICHM1_1
T2T-CHM13v2.014100,037,379 - 100,042,856 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Ighg3
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:96
Interacting mature miRNAs:98
Transcripts:ENSMUST00000103423
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000103423   ⟹   ENSMUSP00000100219
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,323,195 - 113,324,852 (-)Ensembl
GRCm38.p6 Ensembl12113,359,575 - 113,361,232 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223179   ⟹   ENSMUSP00000152559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,319,844 - 113,324,852 (-)Ensembl
GRCm38.p6 Ensembl12113,356,224 - 113,361,232 (-)Ensembl
Protein Sequences
GenBank Protein AAB59697 (Get FASTA)   NCBI Sequence Viewer  
  AAT74921 (Get FASTA)   NCBI Sequence Viewer  
  BAA03476 (Get FASTA)   NCBI Sequence Viewer  
  BAD21435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100219.2
  ENSMUSP00000152559.2
Reference Protein Sequences
RefSeq Acc Id: ENSMUSP00000152559   ⟸   ENSMUST00000223179
RefSeq Acc Id: ENSMUSP00000100219   ⟸   ENSMUST00000103423
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P03987-F1-model_v2 AlphaFold P03987 1-398 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2144790 AgrOrtholog
Ensembl Genes ENSMUSG00000076615 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103423.3 UniProtKB/TrEMBL
  ENSMUST00000223179.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
MGD MGI:2144790 ENTREZGENE
NCBI Gene Ighg3 ENTREZGENE
PANTHER IG GAMMA-3 CHAIN C REGION UniProtKB/TrEMBL
  IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED UniProtKB/TrEMBL
  TAPASIN UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
PhenoGen Ighg3 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A075B5P5_MOUSE UniProtKB/TrEMBL
  A0A1Y7VJN6_MOUSE UniProtKB/TrEMBL
  A0A4E9FT70_MOUSE UniProtKB/TrEMBL
  A0A4U9FKB1_MOUSE UniProtKB/TrEMBL
  Q6KAM2_MOUSE UniProtKB/TrEMBL