Ighd (immunoglobulin heavy constant delta) - Rat Genome Database

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Gene: Ighd (immunoglobulin heavy constant delta) Mus musculus
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Symbol: Ighd
Name: immunoglobulin heavy constant delta
RGD ID: 11296376
MGI Page MGI
Description: Enables antigen binding activity. Acts upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of B cell proliferation; and somatic hypermutation of immunoglobulin genes. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to human IGHD (immunoglobulin heavy constant delta).
Type: gene (Ensembl: IG_C_gene)
RefSeq Status: VALIDATED
Previously known as: Ig; IgD; Igh-5
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,371,155 - 113,379,944 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,370,224 - 113,379,944 (-)EnsemblGRCm39 Ensembl
GRCm3812113,407,535 - 113,416,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,406,604 - 113,416,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,645,746 - 114,654,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12114,591,062 - 114,615,726 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
antigen binding  (IBA,IMP)

Phenotype Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:412775   PMID:1838007   PMID:1922069   PMID:1956380   PMID:6407007   PMID:6801528   PMID:6804095   PMID:6806821   PMID:6895102   PMID:6968091   PMID:7814874   PMID:8041705  
PMID:8418208   PMID:8446604   PMID:8566034   PMID:8666928   PMID:8765046   PMID:9254656   PMID:9655395   PMID:10087188   PMID:15608191   PMID:15843532   PMID:15909309   PMID:17124007  
PMID:19861679   PMID:21352206   PMID:21873635   PMID:22527518   PMID:25848865   PMID:27830696   PMID:28461496   PMID:29521626   PMID:30291028   PMID:31015337  


Genomics

Comparative Map Data
Ighd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,371,155 - 113,379,944 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,370,224 - 113,379,944 (-)EnsemblGRCm39 Ensembl
GRCm3812113,407,535 - 113,416,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,406,604 - 113,416,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,645,746 - 114,654,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12114,591,062 - 114,615,726 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI
IGHD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,838,401 - 105,845,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,836,765 - 105,845,677 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,304,737 - 106,312,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,375,782 - 105,383,055 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,235,179 - 86,242,452 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,437,401 - 86,444,674 (-)NCBIHuRef
CHM1_114106,175,357 - 106,182,633 (-)NCBICHM1_1
T2T-CHM13v2.014100,109,865 - 100,117,138 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Ighd
21 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000192250   ⟹   ENSMUSP00000141946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,373,172 - 113,379,944 (-)Ensembl
GRCm38.p6 Ensembl12113,409,552 - 113,416,324 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194162   ⟹   ENSMUSP00000141353
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12113,370,224 - 113,379,944 (-)Ensembl
GRCm38.p6 Ensembl12113,406,604 - 113,416,324 (-)Ensembl
Protein Sequences
GenBank Protein AAA39339 (Get FASTA)   NCBI Sequence Viewer  
  CAA24162 (Get FASTA)   NCBI Sequence Viewer  
  CAA24163 (Get FASTA)   NCBI Sequence Viewer  
  CAA24164 (Get FASTA)   NCBI Sequence Viewer  
  CAA24166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000141353.2
  ENSMUSP00000141946.2
Reference Protein Sequences
RefSeq Acc Id: ENSMUSP00000141353   ⟸   ENSMUST00000194162
RefSeq Acc Id: ENSMUSP00000141946   ⟸   ENSMUST00000192250
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01881-F1-model_v2 AlphaFold P01881 1-257 view protein structure
AF-P01882-F1-model_v2 AlphaFold P01882 1-290 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96447 AgrOrtholog
Ensembl Genes ENSMUSG00000104213 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000192250.2 UniProtKB/TrEMBL
  ENSMUST00000194162.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
MGD MGI:96447 ENTREZGENE
NCBI Gene Ighd ENTREZGENE
PANTHER IG DELTA CHAIN C REGION MEMBRANE-BOUND FORM-RELATED UniProtKB/TrEMBL
  TAPASIN UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
PhenoGen Ighd PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0A6YW14_MOUSE UniProtKB/TrEMBL
  A0A0A6YXD7_MOUSE UniProtKB/TrEMBL