Ighv14-4 (immunoglobulin heavy variable 14-4) - Rat Genome Database

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Gene: Ighv14-4 (immunoglobulin heavy variable 14-4) Mus musculus
Analyze
No known orthologs.
Symbol: Ighv14-4
Name: immunoglobulin heavy variable 14-4
RGD ID: 11285992
MGI Page MGI
Description: Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Orthologous to human IGHV1-24 (immunoglobulin heavy variable 1-24) and IGHV1-69-2 (immunoglobulin heavy variable 1-69-2).
Type: gene (Ensembl: IG_V_gene)
RefSeq Status: VALIDATED
Previously known as: Gm16841; VH-D-J
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912114,140,058 - 114,140,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12114,140,058 - 114,140,487 (-)EnsemblGRCm39 Ensembl
GRCm3812114,176,438 - 114,176,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12114,176,438 - 114,176,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712115,414,649 - 115,415,528 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,456,035 - 108,456,488 (-)NCBIMGSCv36mm8
MGSCv3612114,624,222 - 114,624,675 (-)NCBIMGSCv36mm8
Cytogenetic Map12F1NCBI
cM Map1262.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:1376351   PMID:1489727   PMID:15608191   PMID:21873635  


Genomics

Variants

.
Variants in Ighv14-4
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:117
Interacting mature miRNAs:124
Transcripts:ENSMUST00000103475
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000103475   ⟹   ENSMUSP00000100256
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12114,140,064 - 114,140,482 (-)Ensembl
GRCm38.p6 Ensembl12114,176,444 - 114,176,862 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195706   ⟹   ENSMUSP00000141226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12114,140,058 - 114,140,487 (-)Ensembl
GRCm38.p6 Ensembl12114,176,438 - 114,176,867 (-)Ensembl
Protein Sequences
GenBank Protein AAA40549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100256.2
  ENSMUSP00000141226.2
Ensembl Acc Id: ENSMUSP00000100256   ⟸   ENSMUST00000103475
Ensembl Acc Id: ENSMUSP00000141226   ⟸   ENSMUST00000195706
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A075B5S3-F1-model_v2 AlphaFold A0A075B5S3 1-111 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:4439765 AgrOrtholog
Ensembl Genes ENSMUSG00000076666 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103475.2 UniProtKB/TrEMBL
  ENSMUST00000195706.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  IgHV UniProtKB/TrEMBL
MGD MGI:4439765 ENTREZGENE
NCBI Gene Ighv14-4 ENTREZGENE
PANTHER IMMUNOGLOBULIN HEAVY CHAIN UniProtKB/TrEMBL
  IMMUNOGLOBULIN HEAVY VARIABLE 14-4 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Ighv14-4 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGv UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A075B5S3_MOUSE UniProtKB/TrEMBL
  A0A0A6YVR1_MOUSE UniProtKB/TrEMBL