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Gene: Itpa (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) Mus musculus
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Symbol: Itpa
Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
RGD ID: 10820
Description: Exhibits dITP diphosphatase activity. Involved in ITP catabolic process and chromosome organization. Predicted to localize to cytosol and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); early infantile epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010016I08Rik; AU020102; I; inosine triphosphate pyrophosphatase; Itp; ITPase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; NTPase; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase
Orthologs:
Homo sapiens (human) : ITPA (inosine triphosphatase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itpa (inosine triphosphatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpa (inosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPA (inosine triphosphatase)
Canis lupus familiaris (dog) : ITPA (inosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpa (inosine triphosphatase)
Sus scrofa (pig) : ITPA (inosine triphosphatase)
Chlorocebus sabaeus (African green monkey) : ITPA (inosine triphosphatase)
Heterocephalus glaber (naked mole-rat) : Itpa (inosine triphosphatase)
more info ...
Related Pseudogenes: Itpa-ps1   Itpa-ps2   Itpa-ps3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl2130,667,610 - 130,681,614 (+)EnsemblGRCm38mm10GRCm38
GRCm382130,664,692 - 130,681,614 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372130,493,577 - 130,507,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,359,282 - 130,373,055 (+)NCBImm8
Celera2131,892,647 - 131,906,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itpa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10820
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.