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Gene: Itpa (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) Mus musculus
Symbol: Itpa
Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
RGD ID: 10820
Description: Exhibits dITP diphosphatase activity. Involved in ITP catabolic process and chromosome organization. Predicted to localize to cytosol and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); early infantile epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010016I08Rik; AU020102; I; inosine triphosphate pyrophosphatase; Itp; ITPase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; NTPase; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase
Homo sapiens (human) : ITPA (inosine triphosphatase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itpa (inosine triphosphatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpa (inosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPA (inosine triphosphatase)
Canis lupus familiaris (dog) : ITPA (inosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpa (inosine triphosphatase)
Sus scrofa (pig) : ITPA (inosine triphosphatase)
Chlorocebus sabaeus (African green monkey) : ITPA (inosine triphosphatase)
Heterocephalus glaber (naked mole-rat) : Itpa (inosine triphosphatase)
more info ...
Related Pseudogenes: Itpa-ps1   Itpa-ps2   Itpa-ps3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl2130,667,610 - 130,681,614 (+)EnsemblGRCm38mm10GRCm38
GRCm382130,664,692 - 130,681,614 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372130,493,577 - 130,507,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,359,282 - 130,373,055 (+)NCBImm8
Celera2131,892,647 - 131,906,412 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itpa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10820
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.