Igkc (immunoglobulin kappa constant)

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Gene: Igkc (immunoglobulin kappa constant) Mus musculus

Analyze

Symbol:

Igkc

Name:

immunoglobulin kappa constant

RGD ID:

10783

MGI Page

MGI

Description:

Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human IGKC (immunoglobulin kappa constant); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254; cisplatin.

Type:

gene

RefSeq Status:

VALIDATED

Also known as:

Igk-C; immunoglobulin kappa chain, constant region

RGD Orthologs

Human

Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	70,703,419 - 70,703,738 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	70,703,419 - 70,703,950 (+)	Ensembl
GRCm38	6	70,726,435 - 70,726,754 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	70,726,435 - 70,726,966 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	70,676,429 - 70,676,748 (+)	NCBI	GRCm37		mm9	NCBIm37
Celera	6	72,811,869 - 72,812,188 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	32.04	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

dysgammaglobulinemia (ISO)

Hepatomegaly (ISO)

IMMUNOGLOBULIN KAPPA LIGHT CHAIN DEFICIENCY (ISO)

myositis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-chloropropane-1,2-diol (ISO)

4,4'-diaminodiphenylmethane (ISO)

Aroclor 1254 (EXP)

arsenous acid (ISO)

bacitracin (ISO)

cadmium atom (ISO)

cisplatin (EXP,ISO)

cyclophosphamide (EXP)

diarsenic trioxide (ISO)

ethyl methanesulfonate (ISO)

ibuprofen (ISO)

ketoconazole (ISO)

methcathinone (ISO)

methyl methanesulfonate (ISO)

microcystin-LR (EXP)

milrinone (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

phenobarbital (EXP)

progesterone (ISO)

silicon dioxide (EXP)

testosterone (EXP)

tetrachloromethane (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vancomycin (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell differentiation (IMP)

B cell receptor signaling pathway (IBA)

complement activation, classical pathway (IBA)

defense response to bacterium (IBA)

innate immune response (IBA)

opsonization (TAS)

phagocytosis, engulfment (IBA)

phagocytosis, recognition (IBA)

positive regulation of B cell activation (IBA)

retina homeostasis (ISO)

Cellular Component

external side of plasma membrane (IBA)

extracellular region (TAS)

immunoglobulin complex, circulating (IBA)

plasma membrane (TAS)

Molecular Function

antigen binding (IBA)

immunoglobulin receptor binding (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal B cell differentiation (IAGP)

abnormal B cell morphology (IAGP)

abnormal B cell number (IAGP)

abnormal B cell physiology (IAGP)

abnormal humoral immune response (IAGP)

abnormal immature B cell morphology (IAGP)

abnormal immune system morphology (IAGP)

abnormal immunoglobulin heavy chain V(D)J recombination (IAGP)

abnormal immunoglobulin level (IAGP)

abnormal immunoglobulin light chain V-J recombination (IAGP)

abnormal Peyer's patch germinal center morphology (IAGP)

abnormal Peyer's patch morphology (IAGP)

abnormal plasma cell morphology (IAGP)

absent B cells (IAGP)

absent B-1 B cells (IAGP)

absent B-2 B cells (IAGP)

absent mature B cells (IAGP)

arrested B cell differentiation (IAGP)

decreased B cell number (IAGP)

decreased IgG level (IAGP)

decreased IgM level (IAGP)

decreased immature B cell number (IAGP)

decreased mature B cell number (IAGP)

decreased pre-B cell number (IAGP)

increased immature B cell number (IAGP)

increased late pro-B cell number (IAGP)

increased mature B cell number (IAGP)

increased pre-B cell number (IAGP)

spleen hypoplasia (IAGP)

References

References - curated


1.	MGD and Homologene mouse data transfer
2.	MGD IEA
3.	RGD automated import pipeline
4.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:103004	PMID:103625	PMID:103631	PMID:111144	PMID:111146	PMID:111241	PMID:1512540	PMID:1749770	PMID:1778474	PMID:1974568	PMID:2115001	PMID:2119497
PMID:2431059	PMID:2563357	PMID:2898504	PMID:2987114	PMID:2995250	PMID:3138071	PMID:3138116	PMID:3926938	PMID:3927151	PMID:3932578	PMID:3937724	PMID:4638343
PMID:5073237	PMID:6170937	PMID:6206194	PMID:6222379	PMID:6249337	PMID:6262318	PMID:6277505	PMID:6290320	PMID:6291785	PMID:6296832	PMID:6403866	PMID:6409419
PMID:6415486	PMID:6775818	PMID:6785724	PMID:6791832	PMID:7664778	PMID:7704573	PMID:7733512	PMID:8027997	PMID:8066444	PMID:8075633	PMID:8080841	PMID:8235658
PMID:8390965	PMID:8429833	PMID:8436414	PMID:8436417	PMID:8458339	PMID:8511672	PMID:8558010	PMID:8563168	PMID:8566019	PMID:8618913	PMID:8661711	PMID:8751373
PMID:8751726	PMID:8766569	PMID:8768802	PMID:8808678	PMID:8964510	PMID:9020839	PMID:9032278	PMID:9075923	PMID:9316642	PMID:9413990	PMID:9545251	PMID:9603450
PMID:9670948	PMID:9687526	PMID:9712877	PMID:10330440	PMID:10514009	PMID:10586043	PMID:10648924	PMID:10700473	PMID:11222858	PMID:11489994	PMID:12427018	PMID:12477932
PMID:12515535	PMID:12538695	PMID:12721618	PMID:12740607	PMID:12796466	PMID:12948492	PMID:14975236	PMID:15608191	PMID:16511898	PMID:16785310	PMID:17546032	PMID:18086860
PMID:18354197	PMID:18584871	PMID:19001071	PMID:19116268	PMID:19561045	PMID:21441452	PMID:21873635	PMID:22043016	PMID:22927551	PMID:23267014	PMID:23296705	PMID:23319731
PMID:23940276	PMID:24457600	PMID:24888588	PMID:25559567	PMID:26173808	PMID:26915335	PMID:27923880	PMID:28378742	PMID:28438896	PMID:28886586	PMID:29459677

Genomics

Comparative Map Data

Igkc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	70,703,419 - 70,703,738 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	70,703,419 - 70,703,950 (+)	Ensembl
GRCm38	6	70,726,435 - 70,726,754 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	70,726,435 - 70,726,966 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	70,676,429 - 70,676,748 (+)	NCBI	GRCm37		mm9	NCBIm37
Celera	6	72,811,869 - 72,812,188 (+)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI
cM Map	6	32.04	NCBI

IGKC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	88,857,161 - 88,857,683 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	88,857,361 - 88,857,683 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	89,156,874 - 89,157,196 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	88,937,989 - 88,938,311 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	2	87,632,104 - 87,632,426 (+)	NCBI
Cytogenetic Map	2	p11.2	NCBI
HuRef	2	88,075,653 - 88,166,302 (-)	NCBI		HuRef
CHM1_1	2	89,086,475 - 89,086,797 (-)	NCBI		CHM1_1

Igkc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
RGSC_v3.4	4	102,208,006 - 102,208,502 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	4	17,127,845 - 17,128,341 (+)	NCBI		Celera
Cytogenetic Map	4	q31	NCBI

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301876	Bits2_m	bitterness sensitivity 2 (mouse)			Not determined		6	70425898	104426034	Mouse
1301813	Skl3_m	skeletal size (tail length) 3 (mouse)			Not determined		6	70425898	104426034	Mouse
1301326	Trbv4c2_m	T cell receptor beta variable 4 (mouse)			Not determined		6	40891296	71379171	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38669625	92607450	Mouse
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	1	117500000	Mouse
10043972	Obq28_m	obesity QTL 28 (mouse)			Not determined		6	58540433	92540433	Mouse
12910802	Pwbwq12_m	post-weaning body weight QTL 12 (mouse)					6	43826813	77811523	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48720000	125360000	Mouse
12910785	Pwgrq16_m	post-weaning growth rate QTL 16 (mouse)					6	43826813	77811523	Mouse
13208564	Bmiq7_m	body mass index QTL 7 (mouse)					6	25000000	80000000	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96656149	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96656149	Mouse
1301369	Im4_m	immunoregulatory 4 (mouse)			Not determined		6	63484738	97484905	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45314059	87426034	Mouse
10043885	Cia6c_m	collagen induced arthritis QTL 6c (mouse)			Not determined		6	44465871	71119467	Mouse
10412213	Sxbq2_m	SGC/Knj cross B6 QTL 2 (mouse)			Not determined		6	19912686	71322775	Mouse
12910807	Pwbwq11_m	post-weaning body weight QTL 11 (mouse)					6	43826813	77811523	Mouse
1300650	Bw18_m	body weight QTL 18 (mouse)			Not determined		6	66713869	100714031	Mouse
1301740	Bwq2_m	body weight QTL 2 (mouse)			Not determined		6	60057680	94057799	Mouse
26884441	Sklq3_m	skull length QTL 3, 5 week (mouse)					6	7600000	80600000	Mouse
12910820	Ogrq3_m	overall growth rate QTL 3 (mouse)					6	43826813	77811523	Mouse
1357442	Dbts1_m	diabetes 1 (mouse)			Not determined		6	18234148	73387692	Mouse
4140983	Srilp_m	sleep response to influenza, light phase (mouse)			Not determined			48726556	75447710	Mouse
15039373	Adip28_m	adiposity 28 (mouse)					6	56308211	90308211	Mouse
15039375	Bw41_m	body weight QTL 41 (mouse)					6	56308211	90308211	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52161713	116155267	Mouse
4141782	Mrdq5_m	modifier of retinal degeneration QTL 5 (mouse)			Not determined			32850650	78238974	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46935985	136423692	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54373427	88379171	Mouse
1301034	Egrm2_m	early growth rate (mouse)			Not determined		6	70425898	104426034	Mouse
4141094	Hrtr1_m	heart rate 1 (mouse)			Not determined			36764478	70764478	Mouse
11040601	Lmr4a_m	leishmaniasis resistance 4a (mouse)					6	42116373	76116515	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96656149	Mouse
11040600	Lmr4c_m	leishmaniasis resistance 4c (mouse)					6	42116373	76116515	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139100000	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87426034	Mouse
1558977	Skmw10_m	skeletal muscle weight 10 (mouse)			Not determined		6	58447583	92447710	Mouse
12880424	V25Dq4_m	vitamin D inactive form serum level QTL 4 (mouse)					6	41600000	75600000	Mouse
11533915	Mts4_m	mammary tumor susceptibility 4 (mouse)					6	42116373	76116515	Mouse
1301266	Lmr4_m	leishmaniasis resistance 4 (mouse)			Not determined		6	42116373	76116515	Mouse
12910798	Pwgrq5_m	pre-weaning growth rate QTL 5 (mouse)					6	43826813	77811523	Mouse
14746995	Manh60_m	mandible shape 60 (mouse)					6	37225677	71225677	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96656149	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48720000	148450000	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51179150	85179300	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45314059	128835032	Mouse
12910809	Pwbwq10_m	post-weaning body weight QTL 10 (mouse)					6	43826813	77811523	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48726556	125356785	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	174
Count of miRNA genes:	158
Interacting mature miRNAs:	162
Transcripts:	ENSMUST00000103410
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_005612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC153612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC110685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U29147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	V00777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	V00807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z22077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z27396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000103410 ⟹ ENSMUSP00000100206

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	70,726,435 - 70,726,966 (+)	Ensembl

Protein Sequences


GenBank Protein	AAC52821	(Get FASTA)	NCBI Sequence Viewer
	CAA24189	(Get FASTA)	NCBI Sequence Viewer
	CAA80051	(Get FASTA)	NCBI Sequence Viewer
	CAA81787	(Get FASTA)	NCBI Sequence Viewer
	P01837	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSMUSP00000100206 ⟸ ENSMUST00000103410

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96495	AgrOrtholog
Ensembl Genes	ENSMUSG00000076609	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000100206	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000103410	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig/MHC_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_C1-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
MGD	MGI:96495	ENTREZGENE
NCBI Gene	Igkc	ENTREZGENE
Pfam	C1-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	V-set	UniProtKB/TrEMBL
PhenoGen	Igkc	PhenoGen
PROSITE	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IG_MHC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	IGc1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGv	UniProtKB/TrEMBL
	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A4U9FD83_MOUSE	UniProtKB/TrEMBL
	A0A5H1ZRK8_MOUSE	UniProtKB/TrEMBL
	A2NHM3_MOUSE	UniProtKB/TrEMBL
	A2P1G9_MOUSE	UniProtKB/TrEMBL
	IGKC_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A075B5P2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-12	Igkc	immunoglobulin kappa constant	Igk-C	immunoglobulin kappa chain, constant region	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM