Gabrb2 (gamma-aminobutyric acid type A receptor subunit beta 2) - Rat Genome Database

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Gene: Gabrb2 (gamma-aminobutyric acid type A receptor subunit beta 2) Mus musculus
Analyze
Symbol: Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2 (Ensembl:gamma-aminobutyric acid (GABA) A receptor, subunit beta 2)
RGD ID: 10612
MGI Page MGI
Description: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in inner ear development and nervous system development. Acts upstream of or within chemical postsynaptic transmission; monoatomic ion transmembrane transport; and regulation of postsynaptic membrane potential. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI834970; C030002O17Rik; C030021G16Rik; GABA(A) receptor subunit beta-2; Gabrab2; Gabrb; Gabrb-2; gamma-aminobutyric acid (GABA) A receptor, subunit beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; gamma-aminobutyric acid receptor beta-2 subunit; gamma-aminobutyric acid receptor subunit beta-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391142,310,342 - 42,523,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1142,310,584 - 42,519,855 (+)EnsemblGRCm39 Ensembl
GRCm381142,419,515 - 42,632,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1142,419,757 - 42,629,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv371142,233,259 - 42,446,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361142,263,180 - 42,472,451 (+)NCBIMGSCv36mm8
Celera1146,252,427 - 46,464,396 (+)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-isoborneol  (ISO)
(R)-camphor  (ISO)
1,2-dimethylhydrazine  (EXP)
1-(2-methoxyphenyl)piperazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,6-Dimethylphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4-ethyl-4-methylpiperidine-2,6-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
acamprosate  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Alphaxolone  (ISO)
ammonium chloride  (ISO)
anthracenes  (ISO)
antirheumatic drug  (ISO)
avermectin  (ISO)
benzamide  (EXP)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromoform  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
camphor  (ISO)
carbamazepine  (ISO)
carisoprodol  (ISO)
carvone  (ISO)
chlorpyrifos  (EXP,ISO)
cocaine  (ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diazepam  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etomidate  (EXP,ISO)
famotidine  (ISO)
felbamate  (ISO)
fipronil  (ISO)
flurazepam  (EXP)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
hexachlorophene  (EXP)
ketamine  (ISO)
lipopolysaccharide  (EXP)
menthone  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
muscimol  (EXP,ISO)
naltrexone  (ISO)
nickel atom  (ISO)
Niflumic acid  (ISO)
o-cresol  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
pregnenolone sulfate  (ISO)
propofol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
tert-Butylbicyclophosphorothionate  (ISO)
theophylline  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topiramate  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vorinostat  (ISO)
zaleplon  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zolpidem  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. Kniazeff J, etal., J Neurosci 2002 Sep 1;22(17):7352-61.
2. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma DQ, etal., Am J Hum Genet. 2005 Sep;77(3):377-88. Epub 2005 Jul 15.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1282920   PMID:1661635   PMID:7643102   PMID:7646429   PMID:7893750   PMID:8613747   PMID:8665663   PMID:8889548   PMID:9882498   PMID:10349636   PMID:10407039   PMID:10882481  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11331371   PMID:11745664   PMID:11875023   PMID:11902122   PMID:12477932   PMID:12490572   PMID:12574411   PMID:12925894   PMID:13679430  
PMID:14681479   PMID:15166563   PMID:15549469   PMID:15939374   PMID:16095914   PMID:16141072   PMID:16141073   PMID:16354909   PMID:16436183   PMID:16602821   PMID:16627470   PMID:16714082  
PMID:16754670   PMID:16882014   PMID:16927170   PMID:17021187   PMID:17953485   PMID:18063661   PMID:18079158   PMID:18799693   PMID:18985723   PMID:19524116   PMID:19763268   PMID:20519520  
PMID:21267068   PMID:21821099   PMID:21873635   PMID:22025726   PMID:22723691   PMID:22768092   PMID:22989919   PMID:23205938   PMID:23486367   PMID:24055402   PMID:24213971   PMID:24417662  
PMID:24427155   PMID:24952961   PMID:25708312   PMID:26179122   PMID:26297893   PMID:27129275   PMID:27540587   PMID:28676743   PMID:29184203   PMID:29706582   PMID:29950725   PMID:30013074  
PMID:30333479   PMID:31138677   PMID:31772151   PMID:34321999   PMID:35355020   PMID:36287173   PMID:36417873   PMID:36604605   PMID:38187761  


Genomics

Comparative Map Data
Gabrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391142,310,342 - 42,523,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1142,310,584 - 42,519,855 (+)EnsemblGRCm39 Ensembl
GRCm381142,419,515 - 42,632,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1142,419,757 - 42,629,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv371142,233,259 - 42,446,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361142,263,180 - 42,472,451 (+)NCBIMGSCv36mm8
Celera1146,252,427 - 46,464,396 (+)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.08NCBI
GABRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385161,288,436 - 161,548,404 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5161,288,429 - 161,549,044 (-)EnsemblGRCh38hg38GRCh38
GRCh375160,715,443 - 160,975,410 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365160,648,014 - 160,907,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 345160,653,448 - 160,907,708NCBI
Celera5156,747,290 - 157,006,998 (-)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5155,807,898 - 156,067,549 (-)NCBIHuRef
CHM1_15160,147,827 - 160,407,563 (-)NCBICHM1_1
T2T-CHM13v2.05161,817,252 - 162,077,933 (-)NCBIT2T-CHM13v2.0
Gabrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81027,438,127 - 27,657,680 (+)NCBIGRCr8
mRatBN7.21026,936,592 - 27,156,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,936,551 - 27,151,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1031,687,629 - 31,916,745 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01031,176,165 - 31,405,281 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,662,808 - 26,891,915 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,973,694 - 28,193,072 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,973,681 - 28,187,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01027,816,796 - 28,032,603 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41027,602,085 - 27,819,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11027,603,057 - 27,820,693 (+)NCBI
Celera1026,450,647 - 26,662,574 (+)NCBICelera
Cytogenetic Map10q21NCBI
Gabrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540815,131,909 - 15,363,169 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540815,126,235 - 15,363,169 (-)NCBIChiLan1.0ChiLan1.0
GABRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24156,474,166 - 156,733,420 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15154,613,712 - 154,872,963 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05156,678,750 - 156,937,614 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15163,373,530 - 163,632,301 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5163,374,346 - 163,632,301 (-)Ensemblpanpan1.1panPan2
GABRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1449,342,527 - 49,579,697 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl449,342,508 - 49,578,092 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha449,230,876 - 49,476,874 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0449,771,687 - 49,919,166 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl449,771,977 - 50,018,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1449,578,711 - 49,828,742 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0449,712,838 - 49,956,441 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0450,235,113 - 50,479,017 (+)NCBIUU_Cfam_GSD_1.0
Gabrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213103,677,848 - 103,910,350 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365152,127,693 - 2,355,090 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365152,127,107 - 2,359,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1661,984,925 - 62,239,937 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11661,984,923 - 62,240,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21667,212,830 - 67,464,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GABRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12363,636,094 - 63,894,587 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2363,637,109 - 63,893,370 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603413,661,103 - 13,924,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473328,022,635 - 28,230,865 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473328,022,632 - 28,236,211 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrb2
7445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:874
Count of miRNA genes:559
Interacting mature miRNAs:669
Transcripts:ENSMUST00000007797, ENSMUST00000136050, ENSMUST00000140463, ENSMUST00000143626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
10043922Alcw9_malcohol withdrawal 9 (mouse)Not determined113557861644065931Mouse
1301718Pbw3_mpentobarbital withdrawal QTL 3 (mouse)Not determined113557861644065931Mouse
1558769Zolw1_mzolpidem withdrawal 1 (mouse)Not determined113557861644065931Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse

Markers in Region
11.MMHAP5FRD8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381142,472,120 - 42,472,275UniSTSGRCm38
MGSCv371142,285,622 - 42,285,777UniSTSGRCm37
Celera1146,304,984 - 46,305,139UniSTS
Cytogenetic Map11A5UniSTS
cM Map1128.6UniSTS
Whitehead_YAC11 UniSTS
U14419  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381142,627,082 - 42,627,236UniSTSGRCm38
MGSCv371142,440,584 - 42,440,738UniSTSGRCm37
Celera1146,458,887 - 46,459,041UniSTS
Cytogenetic Map11A5UniSTS
cM Map1128.6UniSTS
Whitehead_YAC11 UniSTS
D11Mit174  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381142,593,949 - 42,594,095UniSTSGRCm38
MGSCv371142,407,451 - 42,407,597UniSTSGRCm37
Celera1146,426,422 - 46,426,568UniSTS
Cytogenetic Map11A5UniSTS
cM Map1120.0UniSTS
Whitehead Genetic1118.6UniSTS
Whitehead/MRC_RH11576.32UniSTS
Whitehead_YAC11 UniSTS
D11Mit308  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381142,465,288 - 42,465,389UniSTSGRCm38
MGSCv371142,278,790 - 42,278,891UniSTSGRCm37
Celera1146,298,041 - 46,298,148UniSTS
Cytogenetic Map11A5UniSTS
cM Map1120.0UniSTS
Whitehead Genetic1118.6UniSTS
Whitehead/MRC_RH11574.4UniSTS
Whitehead_YAC11 UniSTS
Gabrb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map1128.6UniSTS
AI834970  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381142,631,952 - 42,632,032UniSTSGRCm38
MGSCv371142,445,454 - 42,445,534UniSTSGRCm37
Celera1146,463,757 - 46,463,837UniSTS
Cytogenetic Map11A5UniSTS
cM Map1128.6UniSTS
Whitehead/MRC_RH11577.52UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001362649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH012051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW489190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU086167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000007797   ⟹   ENSMUSP00000007797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1142,310,584 - 42,519,855 (+)Ensembl
GRCm38.p6 Ensembl1142,419,757 - 42,629,028 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136050
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1142,312,106 - 42,378,372 (+)Ensembl
GRCm38.p6 Ensembl1142,421,279 - 42,487,545 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1142,310,591 - 42,313,465 (+)Ensembl
GRCm38.p6 Ensembl1142,419,764 - 42,422,638 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1142,312,137 - 42,422,449 (+)Ensembl
GRCm38.p6 Ensembl1142,421,310 - 42,531,622 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192403   ⟹   ENSMUSP00000141868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1142,312,177 - 42,517,718 (+)Ensembl
GRCm38.p6 Ensembl1142,421,350 - 42,626,891 (+)Ensembl
RefSeq Acc Id: NM_001347314   ⟹   NP_001334243
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,312,028 - 42,523,418 (+)NCBI
GRCm381142,421,201 - 42,632,591 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001362646   ⟹   NP_001349575
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,311,267 - 42,523,418 (+)NCBI
GRCm381142,420,440 - 42,632,591 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001362647   ⟹   NP_001349576
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,311,601 - 42,523,418 (+)NCBI
GRCm381142,420,774 - 42,632,591 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001362649   ⟹   NP_001349578
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,310,534 - 42,523,418 (+)NCBI
GRCm381142,419,707 - 42,632,591 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008070   ⟹   NP_032096
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,310,534 - 42,523,418 (+)NCBI
GRCm381142,419,707 - 42,632,591 (+)NCBI
MGSCv371142,233,259 - 42,446,093 (+)RGD
Celera1146,252,427 - 46,464,396 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245560   ⟹   XP_030101420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391142,310,342 - 42,523,401 (+)NCBI
GRCm381142,419,515 - 42,632,574 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032096   ⟸   NM_008070
- Peptide Label: isoform 2 precursor
- UniProtKB: P63137 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101420   ⟸   XM_030245560
- Peptide Label: isoform X1
- UniProtKB: P63137 (UniProtKB/Swiss-Prot),   D1LYT3 (UniProtKB/Swiss-Prot),   A6H6R7 (UniProtKB/Swiss-Prot),   P15432 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001349578   ⟸   NM_001362649
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001349575   ⟸   NM_001362646
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001349576   ⟸   NM_001362647
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001334243   ⟸   NM_001347314
- Peptide Label: isoform 1 precursor
- UniProtKB: D1LYT3 (UniProtKB/Swiss-Prot),   A6H6R7 (UniProtKB/Swiss-Prot),   P15432 (UniProtKB/Swiss-Prot),   P63137 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000007797   ⟸   ENSMUST00000007797
RefSeq Acc Id: ENSMUSP00000141868   ⟸   ENSMUST00000192403

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63137-F1-model_v2 AlphaFold P63137 1-512 view protein structure

Promoters
RGD ID:6820913
Promoter ID:MM_KWN:7009
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_008070,   OTTMUST00000014384
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361142,233,266 - 42,233,766 (+)MPROMDB
RGD ID:6820914
Promoter ID:MM_KWN:7010
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000014385,   UC007IMJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361142,234,616 - 42,235,116 (+)MPROMDB
RGD ID:8674330
Promoter ID:EPDNEW_M15195
Type:initiation region
Name:Gabrb2_1
Description:Mus musculus gamma-aminobutyric acid A receptor, subunit beta2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381142,421,268 - 42,421,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95620 AgrOrtholog
Ensembl Genes ENSMUSG00000007653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000007797 ENTREZGENE
  ENSMUST00000007797.10 UniProtKB/Swiss-Prot
  ENSMUST00000192403 ENTREZGENE
  ENSMUST00000192403.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABAAb_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report mmu:14401 UniProtKB/Swiss-Prot
MGD MGI:95620 ENTREZGENE
NCBI Gene 14401 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 UniProtKB/Swiss-Prot
  PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB GABRB2 RGD
PhenoGen Gabrb2 PhenoGen
PRINTS GABAARBETA UniProtKB/Swiss-Prot
  GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A6H6R7 ENTREZGENE
  D1LYT3 ENTREZGENE
  GBRB2_MOUSE UniProtKB/Swiss-Prot
  P15432 ENTREZGENE
  P63137 ENTREZGENE
  Q3TQF3_MOUSE UniProtKB/TrEMBL
  Q8BT41_MOUSE UniProtKB/TrEMBL
UniProt Secondary A6H6R7 UniProtKB/Swiss-Prot
  D1LYT3 UniProtKB/Swiss-Prot
  P15432 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Gabrb2  gamma-aminobutyric acid type A receptor subunit beta 2  Gabrb2  gamma-aminobutyric acid (GABA) A receptor, subunit beta 2  Symbol and/or name change 5135510 APPROVED