Gene: Ercc5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) Mus musculus
Analyze
Symbol:
Ercc5
Name:
excision repair cross-complementing rodent repair deficiency, complementation group 5
Description:
Predicted to have several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Involved in several processes, including UV protection; determination of adult lifespan; and growth. Predicted to colocalize with the DNA replication factor A complex. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Is expressed in central nervous system and retina. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells homolog; MGC176031; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; Xpg
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ERCC5 (ERCC excision repair 5, endonuclease) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Ercc5 (ERCC excision repair 5, endonuclease) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ercc5 (ERCC excision repair 5, endonuclease) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ERCC5 (ERCC excision repair 5, endonuclease) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ERCC5 (ERCC excision repair 5, endonuclease) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101968680 (DNA repair protein complementing XP-G cells) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ERCC5 (ERCC excision repair 5, endonuclease) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
BIVM-ERCC5 (BIVM-ERCC5 readthrough) HGNC
OMA, OrthoDB
Alliance orthologs 3
Homo sapiens (human):
ERCC5 (ERCC excision repair 5, endonuclease)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Ercc5 (ERCC excision repair 5, endonuclease)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
ercc5 (excision repair cross-complementation group 5)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
RAD2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
mus201
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
xpg-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 1 44,146,948 - 44,181,260 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 1 44,204,589 - 44,238,105 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 1 44,092,393 - 44,125,806 (+) NCBI mm8 Celera 1 44,491,664 - 44,523,751 (+) NCBI Celera Cytogenetic Map 1 C1.1 NCBI cM Map 1 23.55 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Cerebrooculofacioskeletal Syndrome 3 ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal syndrome 3 ClinVar PMID:24700531 Cerebrooculofacioskeletal Syndrome 3 ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Cerebrooculofacioskeletal syndrome 3 ClinVar PMID:11443545 more ... xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:24033266 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:7951246 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:12060391 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:25741868 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:24728327 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar PMID:24728327 , PMID:25741868 xeroderma pigmentosum ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum ClinVar Xeroderma Pigmentosum G / Cockayne Syndrome ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum group g/Cockayne syndrome ClinVar PMID:9096355 Xeroderma Pigmentosum G / Cockayne Syndrome ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum group g/Cockayne syndrome ClinVar PMID:2478446 more ... Xeroderma Pigmentosum G / Cockayne Syndrome ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum and Cockayne syndrome complex ClinVar PMID:25741868 Xeroderma Pigmentosum G / Cockayne Syndrome ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum group g/Cockayne syndrome ClinVar PMID:11443545 more ... Xeroderma Pigmentosum G / Cockayne Syndrome ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum group g/Cockayne syndrome ClinVar PMID:11228268 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group G ClinVar PMID:10026181 more ... xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group G ClinVar PMID:25741868 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group G ClinVar PMID:24033266 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group G ClinVar PMID:24728327 , PMID:25741868 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by term: Xeroderma pigmentosum, group G ClinVar PMID:24728327 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:15082767 , PMID:24033266 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:23255472 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:12060391 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:11841555 more ... xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:10026181 more ... xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:7951246 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:11219864 , PMID:11841555 xeroderma pigmentosum group G ISO RGD:1342473 8554872 ClinVar Annotator: match by OMIM:278780 ClinVar PMID:11841555
Imported Annotations - MGI
xeroderma pigmentosum group G IEA 13592920 OMIM:278780 MouseDO Imported Annotations - OMIM
Cerebrooculofacioskeletal Syndrome 3 ISO RGD:1342473 7240710 OMIM xeroderma pigmentosum group G ISO RGD:1342473 7240710 OMIM
17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of ERCC5 mRNA CTD PMID:15721199 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ERCC5 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1586176 6480464 2, 4-dinitrotoluene affects the expression of ERCC5 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1586176 6480464 2, 6-dinitrotoluene affects the expression of ERCC5 mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:1342473 6480464 4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA CTD PMID:12419474 acetylsalicylic acid increases expression ISO RGD:1342473 6480464 Aspirin results in increased expression of ERCC5 mRNA CTD PMID:11906190 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ERCC5 mRNA CTD PMID:19770486 aflatoxin B1 affects methylation ISO RGD:1342473 6480464 Aflatoxin B1 affects the methylation of ERCC5 intron CTD PMID:30157460 arsane increases expression ISO RGD:1342473 6480464 Arsenic results in increased expression of ERCC5 mRNA CTD PMID:11134558 arsenic atom increases expression ISO RGD:1342473 6480464 Arsenic results in increased expression of ERCC5 mRNA CTD PMID:11134558 benzo[a]pyrene increases mutagenesis ISO RGD:1342473 6480464 Benzo(a)pyrene results in increased mutagenesis of ERCC5 gene CTD PMID:25435355 benzo[a]pyrene affects methylation ISO RGD:1342473 6480464 Benzo(a)pyrene affects the methylation of ERCC5 intron CTD PMID:30157460 benzo[a]pyrene multiple interactions EXP 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA] CTD PMID:14625279 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ERCC5 mRNA CTD PMID:14625279 more ... benzo[a]pyrene increases expression ISO RGD:1342473 6480464 Benzo(a)pyrene results in increased expression of ERCC5 mRNA, Benzo(a)pyrene results in increased expression of ERCC5 protein CTD PMID:19748547 , PMID:27694624 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1342473 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene decreases methylation ISO RGD:1342473 6480464 benzo(e)pyrene results in decreased methylation of ERCC5 intron CTD PMID:30157460 bisphenol A increases expression ISO RGD:1342473 6480464 bisphenol A results in increased expression of ERCC5 mRNA CTD PMID:24901218 bisphenol A affects expression ISO RGD:1586176 6480464 bisphenol A affects the expression of ERCC5 mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:1586176 6480464 fullerene C60 results in decreased expression of ERCC5 mRNA CTD PMID:19167457 cadmium dichloride multiple interactions ISO RGD:1342473 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA CTD PMID:12634122 cadmium dichloride decreases expression ISO RGD:1342473 6480464 Cadmium Chloride results in decreased expression of ERCC5 mRNA CTD PMID:26525392 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of ERCC5 mRNA CTD PMID:20883709 cisplatin decreases response to substance ISO RGD:1342473 6480464 ERCC5 gene SNP results in decreased susceptibility to Cisplatin, ERCC5 mRNA results in decreased susceptibility to Cisplatin CTD PMID:21452186 , PMID:26338418 cisplatin multiple interactions ISO RGD:1586176 6480464 Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA] CTD PMID:26739623 cisplatin increases expression ISO RGD:1586176 6480464 Cisplatin results in increased expression of ERCC5 mRNA CTD PMID:26739623 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of ERCC5 mRNA CTD PMID:25270620 cisplatin multiple interactions ISO RGD:1342473 6480464 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein] more ... CTD PMID:21875941 , PMID:26338418 copper(II) sulfate decreases expression ISO RGD:1342473 6480464 Copper Sulfate results in decreased expression of ERCC5 mRNA CTD PMID:19549813 daidzein affects expression EXP 6480464 daidzein affects the expression of ERCC5 mRNA CTD PMID:15721199 diazinon decreases expression ISO RGD:1342473 6480464 Diazinon results in decreased expression of ERCC5 mRNA CTD PMID:16539210 dibutyl phthalate decreases expression ISO RGD:1586176 6480464 Dibutyl Phthalate results in decreased expression of ERCC5 mRNA CTD PMID:21266533 dichromium trioxide multiple interactions ISO RGD:1342473 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA CTD PMID:12634122 diethylstilbestrol affects expression EXP 6480464 Diethylstilbestrol affects the expression of ERCC5 mRNA CTD PMID:15721199 dorsomorphin multiple interactions ISO RGD:1342473 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA CTD PMID:27188386 fluvastatin multiple interactions ISO RGD:1342473 6480464 [zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA CTD PMID:16996129 hydrogen peroxide multiple interactions ISO RGD:1342473 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein CTD PMID:18951874 hydroxyurea increases expression EXP 6480464 Hydroxyurea results in increased expression of ERCC5 mRNA CTD PMID:12929121 imiquimod increases expression EXP 6480464 imiquimod results in increased expression of ERCC5 mRNA CTD PMID:21878529 kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA CTD PMID:17917374 L-ascorbic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA CTD PMID:17917374 lead diacetate multiple interactions ISO RGD:1342473 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA CTD PMID:12634122 lovastatin multiple interactions ISO RGD:1586176 6480464 Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA] CTD PMID:26739623 lovastatin increases expression ISO RGD:1586176 6480464 Lovastatin results in increased expression of ERCC5 mRNA CTD PMID:26739623 methapyrilene decreases methylation ISO RGD:1342473 6480464 Methapyrilene results in decreased methylation of ERCC5 intron CTD PMID:30157460 methyl methanesulfonate increases expression ISO RGD:1342473 6480464 Methyl Methanesulfonate results in increased expression of ERCC5 mRNA CTD PMID:23649840 mitomycin C increases expression EXP 6480464 Mitomycin results in increased expression of ERCC5 mRNA CTD PMID:25270620 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA, RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ERCC5 mRNA] CTD PMID:17854601 , PMID:17917374 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of ERCC5 mRNA CTD PMID:17854601 p-anisidine increases expression EXP 6480464 4-anisidine results in increased expression of ERCC5 mRNA CTD PMID:12929121 paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of ERCC5 mRNA CTD PMID:12929121 phenethyl isothiocyanate increases expression ISO RGD:1342473 6480464 phenethyl isothiocyanate results in increased expression of ERCC5 mRNA CTD PMID:20442190 phytoestrogen affects expression EXP 6480464 Phytoestrogens affects the expression of ERCC5 mRNA CTD PMID:15721199 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of ERCC5 mRNA CTD PMID:17950772 pirinixic acid multiple interactions EXP 6480464 NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA], PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA] CTD PMID:17950772 potassium chromate multiple interactions EXP 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA] CTD PMID:14625279 potassium dichromate multiple interactions EXP 6480464 [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of ERCC5 mRNA] CTD PMID:14625279 quercetin decreases expression ISO RGD:1342473 6480464 Quercetin results in decreased expression of ERCC5 mRNA CTD PMID:21632981 SB 431542 multiple interactions ISO RGD:1342473 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1342473 6480464 [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA CTD PMID:12634122 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of ERCC5 mRNA CTD PMID:20883709 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of ERCC5 mRNA CTD PMID:16014739 staurosporine affects expression EXP 6480464 Staurosporine affects the expression of ERCC5 mRNA CTD PMID:15721199 sulforaphane increases expression ISO RGD:1342473 6480464 sulforafan results in increased expression of ERCC5 mRNA CTD PMID:20442190 sulindac decreases expression ISO RGD:1342473 6480464 Sulindac results in decreased expression of ERCC5 mRNA CTD PMID:11906190 tert-butyl hydroperoxide decreases expression ISO RGD:1342473 6480464 tert-Butylhydroperoxide results in decreased expression of ERCC5 mRNA CTD PMID:12419474 theophylline multiple interactions ISO RGD:1342473 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of ERCC5 protein CTD PMID:18951874 valproic acid affects expression ISO RGD:1342473 6480464 Valproic Acid affects the expression of ERCC5 mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1342473 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ERCC5 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1342473 6480464 Valproic Acid results in increased expression of ERCC5 mRNA CTD PMID:26272509 vinclozolin increases expression ISO RGD:1586176 6480464 vinclozolin results in increased expression of ERCC5 mRNA CTD PMID:23034163 Y-27632 increases expression ISO RGD:1342473 6480464 Y 27632 results in increased expression of ERCC5 mRNA CTD PMID:20878077 zoledronic acid multiple interactions ISO RGD:1342473 6480464 [zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA CTD PMID:16996129
Biological Process cellular response to DNA damage stimulus IEA UniProtKB-KW:KW-0227 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 determination of adult lifespan IMP MGI:MGI:3043589 2290270 (MGI:MGI:3041918, PMID:15082767) MGI MGI:MGI:3041918 , PMID:15082767 DNA repair IMP MGI:MGI:3043589 2290270 (MGI:MGI:3041918, PMID:15082767) MGI MGI:MGI:3041918 , PMID:15082767 multicellular organism growth IMP MGI:MGI:2182793 2290270 (MGI:MGI:1333374, PMID:10022922) MGI MGI:MGI:1333374 , PMID:10022922 negative regulation of apoptotic process ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleotide-excision repair IMP MGI:MGI:2182793 2290270 (MGI:MGI:1333374, PMID:10022922) MGI MGI:MGI:1333374 , PMID:10022922 nucleotide-excision repair ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleotide-excision repair, DNA incision, 3'-to lesion ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleotide-excision repair, DNA incision, 3'-to lesion IBA PANTHER:PTN000792422 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 response to UV IMP MGI:MGI:3043589 2290270 (MGI:MGI:3041918, PMID:15082767) MGI MGI:MGI:3041918 , PMID:15082767 response to UV ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to UV-C ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription-coupled nucleotide-excision repair ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 UV protection IMP 2290270 (MGI:MGI:77034, PMID:7510366) MGI MGI:MGI:77034 , PMID:7510366 UV protection ISO UniProtKB:P28715 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 UV protection IDA 2290270 (MGI:MGI:82906, PMID:8703115) MGI MGI:MGI:82906 , PMID:8703115 Cellular Component DNA replication factor A complex colocalizes_with ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleotide-excision repair complex ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IBA PANTHER:PTN000792422 , UniProtKB:P28715 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function bubble DNA binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 catalytic activity IEA InterPro:IPR008918 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 DNA binding IEA InterPro:IPR008918 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 double-stranded DNA binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 endodeoxyribonuclease activity ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 endodeoxyribonuclease activity IBA PANTHER:PTN000792422 , UniProtKB:P28715 2290270 (PMID:21873635) GO_Central PMID:21873635 endonuclease activity IEA UniProtKB-KW:KW-0255 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 endonuclease activity IEA InterPro:IPR001044 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 hydrolase activity IEA UniProtKB-KW:KW-0378 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 hydrolase activity, acting on ester bonds IEA InterPro:IPR019974 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nuclease activity IEA UniProtKB-KW:KW-0540 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 nuclease activity IEA InterPro:IPR006084 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 protein homodimerization activity ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein N-terminus binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 RNA polymerase II complex binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 single-stranded DNA binding ISO UniProtKB:P28715 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 single-stranded DNA binding IBA PANTHER:PTN000792422 , UniProtKB:P28715 2290270 (PMID:21873635) GO_Central PMID:21873635
Gene-Chemical Interaction Annotations
