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Gene: Ercc5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) Mus musculus
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Symbol: Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Description: Predicted to have several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Involved in several processes, including UV protection; determination of adult lifespan; and growth. Predicted to colocalize with the DNA replication factor A complex. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Is expressed in central nervous system and retina. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells homolog; MGC176031; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; Xpg
Orthologs:
Homo sapiens (human) : ERCC5 (ERCC excision repair 5, endonuclease)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ercc5 (ERCC excision repair 5, endonuclease)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ercc5 (ERCC excision repair 5, endonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : ERCC5 (ERCC excision repair 5, endonuclease)
Canis lupus familiaris (dog) : ERCC5 (ERCC excision repair 5, endonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968680 (DNA repair protein complementing XP-G cells)
Sus scrofa (pig) : ERCC5 (ERCC excision repair 5, endonuclease)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38144,146,948 - 44,181,260 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37144,204,589 - 44,238,105 (+)NCBIGRCm37mm9NCBIm37
MGSCv36144,092,393 - 44,125,806 (+)NCBImm8
Celera144,491,664 - 44,523,751 (+)NCBICelera
Cytogenetic Map1 C1.1NCBI
cM Map123.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ercc5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10534
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.