Predicted to have several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Involved in several processes, including UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to colocalize with DNA replication factor A complex. Is expressed in central nervous system and retina. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells homolog; MGC176031; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; Xp; Xpg
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [[ERCC5 gene SNP results in decreased susceptibility to Cisplatin] which results in increased expression of ERCC5 protein] more ...
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ERCC5 mRNA
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA
[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of ERCC5 mRNA, RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ERCC5 mRNA]
NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA], PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ERCC5 mRNA]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ERCC5 mRNA
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of ERCC5 mRNA