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Gene: Dcc (deleted in colorectal carcinoma) Mus musculus
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Symbol: Dcc
Name: deleted in colorectal carcinoma
RGD ID: 10465
Description: Predicted to have identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in axonogenesis; neuron migration; and postsynaptic modulation of chemical synaptic transmission. Localizes to Schaffer collateral - CA1 synapse; axon; and integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (S)-amphetamine; 1,2-dichloroethane; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C030036D22Rik; Igdcc; Igdcc1; netrin receptor DCC; tumor suppressor protein DCC
Orthologs:
Homo sapiens (human) : DCC (DCC netrin 1 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dcc (DCC netrin 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dcc (DCC netrin 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : DCC (DCC netrin 1 receptor)
Canis lupus familiaris (dog) : DCC (DCC netrin 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dcc (DCC netrin 1 receptor)
Sus scrofa (pig) : DCC (DCC netrin 1 receptor)
Chlorocebus sabaeus (African green monkey) : DCC (DCC netrin 1 receptor)
Heterocephalus glaber (naked mole-rat) : Dcc (DCC netrin 1 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)EnsemblGRCm38mm10GRCm38
GRCm381871,253,613 - 72,351,228 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371871,413,286 - 72,510,723 (-)NCBIGRCm37mm9NCBIm37
MGSCv361871,384,359 - 72,475,947 (-)NCBImm8
Celera1872,536,536 - 73,631,393 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1845.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dcc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10465
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.