Dcc (DCC netrin 1 receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dcc (DCC netrin 1 receptor) Mus musculus
Analyze
Symbol: Dcc
Name: DCC netrin 1 receptor
RGD ID: 10465
MGI Page MGI
Description: Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is active in Schaffer collateral - CA1 synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study essential thrombocythemia and polycythemia vera. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C030036D22Rik; deleted in colorectal carcinoma; Igdcc; Igdcc1; netrin receptor DCC; tumor suppressor protein DCC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391871,386,703 - 72,484,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1871,386,705 - 72,484,140 (-)EnsemblGRCm39 Ensembl
GRCm381871,253,613 - 72,351,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)EnsemblGRCm38mm10GRCm38
MGSCv371871,413,286 - 72,510,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361871,384,359 - 72,475,947 (-)NCBIMGSCv36mm8
Celera1872,536,536 - 73,631,393 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1845.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
androgen antagonist  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylparaben  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
linuron  (ISO)
methimazole  (ISO)
miconazole  (EXP)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
terbufos  (ISO)
tetraphene  (EXP)
thimerosal  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon guidance  (IAGP)
abnormal brain morphology  (IAGP)
abnormal corticospinal tract morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal gait  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal optic nerve innervation  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal pontine nuclei morphology  (IAGP)
abnormal pyramidal decussation morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal spinal cord dorsal column morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tumor latency  (IAGP)
absent corpus callosum  (IAGP)
absent hippocampal commissure  (IAGP)
ataxia  (IAGP)
decreased apoptosis  (IAGP)
decreased enterocyte apoptosis  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased hematocrit  (IAGP)
decreased spleen white pulp amount  (IAGP)
ectopic neuron  (IAGP)
enhanced megakaryocyte emperipolesis  (IAGP)
enlarged spleen  (IAGP)
increased bone marrow cell number  (IAGP)
increased classified tumor incidence  (IAGP)
increased erythroblast number  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulocyte number  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased neutrophil cell number  (IEA)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
increased tumor incidence  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
polycythemia  (IAGP)
preweaning lethality, complete penetrance  (IEA)
respiratory distress  (IAGP)
thrombocytosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
2. Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. Manitt C, etal., J Neurosci Res. 2006 Dec;84(8):1808-20.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Miyake S, etal., Cancer Res 1994 Jun 1;54(11):3007-10.
7. Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. Moon C, etal., J Neuroimmunol. 2006 Mar;172(1-2):66-72. Epub 2005 Dec 6.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia. Tsuchiya A, etal., Brain Res. 2007 Jul 23;1159:1-7. Epub 2007 Jan 20.
Additional References at PubMed
PMID:1347918   PMID:1354644   PMID:2294591   PMID:7877445   PMID:8044801   PMID:8401479   PMID:8570174   PMID:8697804   PMID:8706013   PMID:8884266   PMID:8903730   PMID:8978605  
PMID:9126737   PMID:9331350   PMID:9441666   PMID:9449674   PMID:10049565   PMID:10341242   PMID:10349636   PMID:10409504   PMID:10409510   PMID:10477289   PMID:10559399   PMID:10595513  
PMID:10683176   PMID:10704383   PMID:10704386   PMID:10843775   PMID:10908620   PMID:10922068   PMID:11042159   PMID:11044395   PMID:11076861   PMID:11157077   PMID:11163266   PMID:11195460  
PMID:11217851   PMID:11387206   PMID:11395003   PMID:11494126   PMID:11527412   PMID:11707574   PMID:11807023   PMID:12351186   PMID:12451134   PMID:12466305   PMID:12736344   PMID:12787506  
PMID:12798294   PMID:12799072   PMID:12840034   PMID:12889066   PMID:14691545   PMID:14750959   PMID:15121176   PMID:15186747   PMID:15328020   PMID:15457507   PMID:15494733   PMID:15494734  
PMID:15510105   PMID:15534618   PMID:15557120   PMID:15632069   PMID:15730872   PMID:15788454   PMID:15828125   PMID:16085498   PMID:16107646   PMID:16123376   PMID:16141072   PMID:16141073  
PMID:16181408   PMID:16244667   PMID:16267219   PMID:16280635   PMID:16284245   PMID:16309667   PMID:16439477   PMID:16510500   PMID:16575185   PMID:16602821   PMID:16715082   PMID:16723533  
PMID:16917820   PMID:17151600   PMID:17237772   PMID:17442818   PMID:17450135   PMID:17573818   PMID:17616930   PMID:17701984   PMID:17884558   PMID:17898204   PMID:17898206   PMID:18005074  
PMID:18033315   PMID:18066058   PMID:18212043   PMID:18479186   PMID:18547144   PMID:18554416   PMID:18585357   PMID:18691385   PMID:18771734   PMID:18796601   PMID:18945908   PMID:19141671  
PMID:19383784   PMID:19409494   PMID:19463158   PMID:19605494   PMID:19788579   PMID:19859539   PMID:19877281   PMID:19906978   PMID:19961580   PMID:20004665   PMID:20159958   PMID:20345916  
PMID:20434207   PMID:20493932   PMID:20628609   PMID:20696379   PMID:20875817   PMID:21059867   PMID:21215373   PMID:21267068   PMID:21273433   PMID:21273545   PMID:21316586   PMID:21653843  
PMID:21743013   PMID:21873635   PMID:21957262   PMID:21994363   PMID:22158121   PMID:22238077   PMID:22281059   PMID:22305526   PMID:22349703   PMID:22358843   PMID:22521513   PMID:22726835  
PMID:22748019   PMID:22782894   PMID:22806432   PMID:22946563   PMID:22998873   PMID:23038776   PMID:23223444   PMID:23291093   PMID:23302812   PMID:23312517   PMID:23534961   PMID:23641072  
PMID:23738838   PMID:23820928   PMID:23948231   PMID:23951024   PMID:24174661   PMID:24346136   PMID:24449837   PMID:24560577   PMID:24739528   PMID:24778312   PMID:24867253   PMID:24876346  
PMID:24884839   PMID:24928309   PMID:24937433   PMID:24952961   PMID:25031414   PMID:25033181   PMID:25056828   PMID:25190801   PMID:25336744   PMID:25366972   PMID:25395421   PMID:25433640  
PMID:25456121   PMID:25530182   PMID:25754961   PMID:25826454   PMID:25913325   PMID:25947198   PMID:25960414   PMID:26005129   PMID:26079645   PMID:26257176   PMID:26264903   PMID:26290247  
PMID:26395479   PMID:26397040   PMID:26503042   PMID:26633881   PMID:26659141   PMID:26687222   PMID:26758845   PMID:26858598   PMID:27040640   PMID:27147649   PMID:27196744   PMID:27223325  
PMID:27223328   PMID:27349434   PMID:27407143   PMID:27539716   PMID:27626380   PMID:27648578   PMID:27784329   PMID:27864010   PMID:28108253   PMID:28250456   PMID:28341853   PMID:28434801  
PMID:28445456   PMID:28691197   PMID:28701345   PMID:28720317   PMID:28986144   PMID:29099309   PMID:29154364   PMID:29343636   PMID:29343638   PMID:29386099   PMID:29444422   PMID:29546593  
PMID:29590626   PMID:29712788   PMID:29770538   PMID:29782851   PMID:29911180   PMID:30224412   PMID:30282026   PMID:30470704   PMID:30470893   PMID:30576266   PMID:30661739   PMID:30893602  
PMID:30902550   PMID:30905607   PMID:31351040   PMID:31392959   PMID:31430342   PMID:31806640   PMID:32096760   PMID:32264905   PMID:32561725   PMID:32562661   PMID:32678266   PMID:32701653  
PMID:33195252   PMID:33238113   PMID:33393489   PMID:33740419   PMID:33798452   PMID:33871356   PMID:33951080   PMID:34063230   PMID:34169076   PMID:34321999   PMID:34722541   PMID:35115383  
PMID:35118677   PMID:35727300   PMID:35864088   PMID:35927240   PMID:36028316   PMID:36074819   PMID:36456775   PMID:36604605   PMID:36963389   PMID:37149867   PMID:37541362   PMID:38187761  
PMID:38355793   PMID:38377003   PMID:38781326  


Genomics

Comparative Map Data
Dcc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391871,386,703 - 72,484,299 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1871,386,705 - 72,484,140 (-)EnsemblGRCm39 Ensembl
GRCm381871,253,613 - 72,351,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)EnsemblGRCm38mm10GRCm38
MGSCv371871,413,286 - 72,510,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361871,384,359 - 72,475,947 (-)NCBIMGSCv36mm8
Celera1872,536,536 - 73,631,393 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1845.24NCBI
DCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381852,340,197 - 53,535,899 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1852,340,197 - 53,535,899 (+)EnsemblGRCh38hg38GRCh38
GRCh371849,866,567 - 51,062,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361848,120,569 - 49,311,780 (+)NCBINCBI36Build 36hg18NCBI36
Build 341848,121,155 - 49,311,286NCBI
Celera1846,722,385 - 47,918,339 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1846,722,887 - 47,917,133 (+)NCBIHuRef
CHM1_11849,861,521 - 51,057,237 (+)NCBICHM1_1
T2T-CHM13v2.01852,543,078 - 53,739,020 (+)NCBIT2T-CHM13v2.0
Dcc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81867,144,272 - 68,248,159 (-)NCBIGRCr8
mRatBN7.21864,868,987 - 65,972,783 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1864,873,898 - 65,972,740 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1866,947,462 - 68,060,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01867,635,044 - 68,751,656 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01865,475,745 - 66,586,354 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01866,518,213 - 67,629,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1866,523,120 - 67,224,566 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01865,688,901 - 66,793,126 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41868,026,795 - 69,140,741 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11868,099,995 - 69,213,942 (-)NCBI
Celera1862,907,666 - 64,001,277 (-)NCBICelera
Cytogenetic Map18q12.1-q12.2NCBI
Dcc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540237,123,795 - 38,218,472 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540237,123,112 - 38,218,876 (+)NCBIChiLan1.0ChiLan1.0
DCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21769,864,630 - 71,059,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11855,557,246 - 56,752,486 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01845,717,924 - 46,913,998 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11849,060,454 - 50,255,116 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1849,268,812 - 50,255,155 (+)Ensemblpanpan1.1panPan2
DCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,788,833 - 22,494,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,793,328 - 22,494,967 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,784,245 - 23,871,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,687,171 - 22,774,992 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,688,158 - 22,774,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,742,849 - 22,829,651 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,635,199 - 22,721,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,906,717 - 22,993,897 (-)NCBIUU_Cfam_GSD_1.0
Dcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494434,878,291 - 35,930,900 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649710,122,617 - 11,169,803 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649710,122,078 - 11,169,900 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1101,846,100 - 103,083,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11101,518,629 - 103,087,021 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,538,098 - 112,878,669 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11827,437,224 - 28,623,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1827,442,489 - 28,212,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660501,432,122 - 2,644,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477815,979,467 - 17,222,039 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477815,979,350 - 17,225,263 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dcc
44203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:151
Interacting mature miRNAs:157
Transcripts:ENSMUST00000073379, ENSMUST00000114943, ENSMUST00000126030
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
1301368Par2_mpulmonary adenoma resistance 2 (mouse)Not determined187036233376707156Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse

Markers in Region
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
cM Map1845.0UniSTS
D18Mit186  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381872,020,418 - 72,020,542UniSTSGRCm38
MGSCv371872,180,072 - 72,180,196UniSTSGRCm37
Celera1873,304,084 - 73,304,192UniSTS
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
Whitehead Genetic1830.6UniSTS
UniSTS:237840  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381871,946,243 - 71,946,547UniSTSGRCm38
MGSCv371872,105,897 - 72,106,201UniSTSGRCm37
Celera1873,229,938 - 73,230,222UniSTS
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
D18Mit141  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381871,874,542 - 71,874,635UniSTSGRCm38
MGSCv371872,034,196 - 72,034,289UniSTSGRCm37
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
Whitehead Genetic1830.6UniSTS
Whitehead/MRC_RH18892.4UniSTS
GDB:201899  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381871,682,162 - 71,682,316UniSTSGRCm38
MGSCv371871,841,816 - 71,841,970UniSTSGRCm37
Celera1872,966,004 - 72,966,158UniSTS
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
GDB:201912  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381871,362,860 - 71,363,002UniSTSGRCm38
MGSCv371871,522,514 - 71,522,656UniSTSGRCm37
Celera1872,645,818 - 72,645,960UniSTS
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
D18Abb2e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381872,331,493 - 72,331,666UniSTSGRCm38
MGSCv371872,491,147 - 72,491,320UniSTSGRCm37
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
Dcc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
cM Map1845.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC167549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ550935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN665025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X85788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000073379   ⟹   ENSMUSP00000073094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1871,392,061 - 72,484,088 (-)Ensembl
GRCm38.p6 Ensembl1871,258,990 - 72,351,017 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114943   ⟹   ENSMUSP00000110593
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1871,386,705 - 72,484,140 (-)Ensembl
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126030
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1872,084,977 - 72,484,112 (-)Ensembl
GRCm38.p6 Ensembl1871,951,906 - 72,351,041 (-)Ensembl
RefSeq Acc Id: NM_007831   ⟹   NP_031857
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391871,386,703 - 72,484,140 (-)NCBI
GRCm381871,253,632 - 72,351,069 (-)NCBI
MGSCv371871,413,286 - 72,510,723 (-)RGD
Celera1872,536,536 - 73,631,393 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006525588   ⟹   XP_006525651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391871,388,405 - 72,484,299 (-)NCBI
GRCm381871,253,613 - 72,351,228 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_031857 (Get FASTA)   NCBI Sequence Viewer  
  XP_006525651 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE34163 (Get FASTA)   NCBI Sequence Viewer  
  CAA59786 (Get FASTA)   NCBI Sequence Viewer  
  EDL09563 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000073094
  ENSMUSP00000073094.6
  ENSMUSP00000110593
  ENSMUSP00000110593.4
GenBank Protein P70211 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031857   ⟸   NM_007831
- Peptide Label: precursor
- UniProtKB: G3X9X6 (UniProtKB/Swiss-Prot),   P70211 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006525651   ⟸   XM_006525588
- Peptide Label: isoform X1
- UniProtKB: P70211 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000073094   ⟸   ENSMUST00000073379
Ensembl Acc Id: ENSMUSP00000110593   ⟸   ENSMUST00000114943
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70211-F1-model_v2 AlphaFold P70211 1-1447 view protein structure

Promoters
RGD ID:13678132
Promoter ID:EPDNEW_M23215
Type:initiation region
Name:Dcc_1
Description:Mus musculus deleted in colorectal carcinoma , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381872,351,039 - 72,351,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:94869 AgrOrtholog
Ensembl Genes ENSMUSG00000060534 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000073379 ENTREZGENE
  ENSMUST00000073379.6 UniProtKB/Swiss-Prot
  ENSMUST00000114943 ENTREZGENE
  ENSMUST00000114943.11 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neogenin_C UniProtKB/Swiss-Prot
KEGG Report mmu:13176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:94869 ENTREZGENE
NCBI Gene 13176 ENTREZGENE
PANTHER PROTEIN SIDEKICK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR44170:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neogenin_C UniProtKB/Swiss-Prot
PhenoGen Dcc PhenoGen
PRINTS FNTYPEIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DCC_MOUSE UniProtKB/Swiss-Prot
  G3X9X6 ENTREZGENE
  P70211 ENTREZGENE
  Q3TZP5_MOUSE UniProtKB/TrEMBL
UniProt Secondary G3X9X6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-04-23 Dcc  DCC netrin 1 receptor  Dcc  deleted in colorectal carcinoma  Symbol and/or name change 5135510 APPROVED