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Gene: Dcc (deleted in colorectal carcinoma) Mus musculus
Symbol: Dcc
Name: deleted in colorectal carcinoma
RGD ID: 10465
Description: Predicted to have identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in axonogenesis; neuron migration; and postsynaptic modulation of chemical synaptic transmission. Localizes to Schaffer collateral - CA1 synapse; axon; and integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (S)-amphetamine; 1,2-dichloroethane; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C030036D22Rik; Igdcc; Igdcc1; netrin receptor DCC; tumor suppressor protein DCC
Homo sapiens (human) : DCC (DCC netrin 1 receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dcc (DCC netrin 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dcc (DCC netrin 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : DCC (DCC netrin 1 receptor)
Canis lupus familiaris (dog) : DCC (DCC netrin 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dcc (DCC netrin 1 receptor)
Sus scrofa (pig) : DCC (DCC netrin 1 receptor)
Chlorocebus sabaeus (African green monkey) : DCC (DCC netrin 1 receptor)
Heterocephalus glaber (naked mole-rat) : Dcc (DCC netrin 1 receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1871,253,634 - 72,351,069 (-)EnsemblGRCm38mm10GRCm38
GRCm381871,253,613 - 72,351,228 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371871,413,286 - 72,510,723 (-)NCBIGRCm37mm9NCBIm37
MGSCv361871,384,359 - 72,475,947 (-)NCBImm8
Celera1872,536,536 - 73,631,393 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1845.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dcc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10465
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.