Cyct (cytochrome c, testis) - Rat Genome Database

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Gene: Cyct (cytochrome c, testis) Mus musculus
Analyze
Symbol: Cyct
Name: cytochrome c, testis
RGD ID: 10426
MGI Page MGI
Description: Enables heme binding activity. Acts upstream of or within hydrogen peroxide metabolic process and positive regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. Is expressed in embryo. Orthologous to human CYCTP (cytochrome c, testis, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome c, testis-specific; T-Cc
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,184,286 - 76,190,797 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,184,286 - 76,190,794 (-)EnsemblGRCm39 Ensembl
GRCm38276,353,942 - 76,360,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,353,942 - 76,360,450 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,192,000 - 76,198,505 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,154,875 - 76,161,287 (-)NCBIMGSCv36mm8
Celera278,020,786 - 78,027,832 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants. Virbasius JV and Scarpulla RC, J Biol Chem 1988 May 15;263(14):6791-6.
Additional References at PubMed
PMID:240690   PMID:1964409   PMID:7984407   PMID:8034327   PMID:8393801   PMID:8570653   PMID:9545497   PMID:10349636   PMID:10501973   PMID:11042159   PMID:11076861   PMID:12101247  
PMID:12477932   PMID:14680842   PMID:16141072   PMID:16141073   PMID:16757556   PMID:17210651   PMID:18614015   PMID:19075019   PMID:21267068   PMID:21677750   PMID:21873635   PMID:26576615  
PMID:30191381   PMID:32325033   PMID:32554809  


Genomics

Comparative Map Data
Cyct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,184,286 - 76,190,797 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,184,286 - 76,190,794 (-)EnsemblGRCm39 Ensembl
GRCm38276,353,942 - 76,360,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,353,942 - 76,360,450 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,192,000 - 76,198,505 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,154,875 - 76,161,287 (-)NCBIMGSCv36mm8
Celera278,020,786 - 78,027,832 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map244.94NCBI
CYCTP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,092,500 - 178,104,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,092,503 - 178,104,470 (-)EnsemblGRCh38hg38GRCh38
GRCh372178,957,227 - 178,969,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362178,665,473 - 178,677,443 (-)NCBINCBI36Build 36hg18NCBI36
Celera2172,560,128 - 172,572,098 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2170,827,693 - 170,839,687 (-)NCBIHuRef
CHM1_12178,963,338 - 178,975,307 (-)NCBICHM1_1
T2T-CHM13v2.02178,575,256 - 178,587,228 (-)NCBIT2T-CHM13v2.0
Cyct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8381,697,333 - 81,704,401 (-)NCBIGRCr8
mRatBN7.2361,290,090 - 61,297,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl360,913,562 - 61,297,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx364,650,427 - 64,657,497 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0373,234,083 - 73,241,153 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0371,001,205 - 71,008,282 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0363,204,779 - 63,211,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl362,818,502 - 63,211,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0369,744,115 - 69,781,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,042,806 - 59,045,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1358,939,177 - 58,942,360 (-)NCBI
Celera360,778,075 - 60,785,143 (-)NCBICelera
Cytogenetic Map3q24NCBI

Variants

.
Variants in Cyct
223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:46
Interacting mature miRNAs:53
Transcripts:ENSMUST00000028430
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028430   ⟹   ENSMUSP00000028430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl276,184,286 - 76,190,794 (-)Ensembl
GRCm38.p6 Ensembl276,353,942 - 76,360,450 (-)Ensembl
RefSeq Acc Id: NM_009989   ⟹   NP_034119
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39276,184,286 - 76,190,797 (-)NCBI
GRCm38276,353,942 - 76,360,453 (-)NCBI
MGSCv37276,192,000 - 76,198,505 (-)RGD
Celera278,020,785 - 78,027,837 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239273   ⟹   XP_011237575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39276,184,286 - 76,190,650 (-)NCBI
GRCm38276,353,942 - 76,360,306 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034119   ⟸   NM_009989
- UniProtKB: P00015 (UniProtKB/Swiss-Prot),   Q6PBG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237575   ⟸   XM_011239273
- Peptide Label: isoform X1
- UniProtKB: P00015 (UniProtKB/Swiss-Prot),   Q6PBG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028430   ⟸   ENSMUST00000028430
Protein Domains
Cytochrome c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00015-F1-model_v2 AlphaFold P00015 1-105 view protein structure

Promoters
RGD ID:6831116
Promoter ID:MM_KWN:29802
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000031706
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36276,198,161 - 76,198,661 (-)MPROMDB
RGD ID:6877698
Promoter ID:EPDNEW_M2299
Type:initiation region
Name:Cyct_1
Description:Mus musculus cytochrome c, testis , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38276,360,431 - 76,360,491EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88579 AgrOrtholog
Ensembl Genes ENSMUSG00000056436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028430 ENTREZGENE
  ENSMUST00000028430.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.760.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_c-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_1A/1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13067 UniProtKB/Swiss-Prot
MGD MGI:88579 ENTREZGENE
NCBI Gene 13067 ENTREZGENE
PANTHER CYTOCHROME C, TESTIS-SPECIFIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11961 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cytochrom_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyct PhenoGen
PRINTS CYTCHRMECIAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46626 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CYC2_MOUSE UniProtKB/Swiss-Prot
  G4XXT0_MOUSE UniProtKB/TrEMBL
  P00015 ENTREZGENE
  Q6PBG3 ENTREZGENE, UniProtKB/TrEMBL