Crygc (crystallin, gamma C) - Rat Genome Database

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Gene: Crygc (crystallin, gamma C) Mus musculus
Analyze
Symbol: Crygc
Name: crystallin, gamma C
RGD ID: 10408
MGI Page MGI
Description: Predicted to be a structural constituent of eye lens. Acts upstream of or within camera-type eye development. Predicted to be located in cytoplasm and nucleus. Is expressed in eye; ileum; reproductive system; and urogenital sinus. Used to study cataract 2 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 2 multiple types. Orthologous to human CRYGC (crystallin gamma C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cryg-; Cryg-5; gamma-C-crystallin; gamma-crystallin C; gammaC-crystallin
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,110,684 - 65,112,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,110,684 - 65,112,848 (-)EnsemblGRCm39 Ensembl
GRCm38165,071,525 - 65,073,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,071,525 - 65,073,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,118,105 - 65,120,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,005,875 - 65,007,781 (-)NCBIMGSCv36mm8
Celera165,564,736 - 65,566,727 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The gamma-crystallins and human cataracts: a puzzle made clearer. Heon E, etal., Am J Hum Genet. 1999 Nov;65(5):1261-7.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1623964   PMID:1889815   PMID:3428594   PMID:3792630   PMID:8293998   PMID:8751373   PMID:9512512   PMID:10080188   PMID:10383433   PMID:10595510   PMID:11146559   PMID:11773036  
PMID:12426373   PMID:12446761   PMID:12477932   PMID:14610273   PMID:15037589   PMID:15215744   PMID:15483628   PMID:15489334   PMID:15593327   PMID:16141072   PMID:16162653   PMID:17327821  
PMID:17659303   PMID:18004741   PMID:19623612   PMID:19624757   PMID:20686773   PMID:21436445   PMID:21873635   PMID:21998302   PMID:24194600   PMID:24315440   PMID:27626380   PMID:36293380  
PMID:37331601  


Genomics

Comparative Map Data
Crygc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,110,684 - 65,112,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,110,684 - 65,112,848 (-)EnsemblGRCm39 Ensembl
GRCm38165,071,525 - 65,073,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,071,525 - 65,073,689 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,118,105 - 65,120,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,005,875 - 65,007,781 (-)NCBIMGSCv36mm8
Celera165,564,736 - 65,566,727 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.81NCBI
CRYGC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,128,137 - 208,129,828 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,128,137 - 208,129,828 (-)EnsemblGRCh38hg38GRCh38
GRCh372208,992,861 - 208,994,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,701,108 - 208,702,872 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,818,368 - 208,820,133NCBI
Celera2202,761,129 - 202,762,822 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,841,316 - 200,843,009 (-)NCBIHuRef
CHM1_12208,998,651 - 209,000,344 (-)NCBICHM1_1
T2T-CHM13v2.02208,608,155 - 208,619,118 (-)NCBIT2T-CHM13v2.0
Crygc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,945,332 - 73,947,367 (-)NCBIGRCr8
mRatBN7.2966,451,591 - 66,453,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,451,593 - 66,453,626 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,964,820 - 74,966,876 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,100,128 - 80,102,167 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,508,558 - 78,510,618 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,786,246 - 71,788,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,786,248 - 71,788,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,780,411 - 70,782,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,720,585 - 63,722,620 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,867,584 - 63,869,472 (-)NCBI
Celera963,847,235 - 63,849,270 (-)NCBICelera
Cytogenetic Map9q32NCBI
LOC100978392
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,733,571 - 110,745,023 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,748,547 - 110,759,999 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,359,514 - 95,361,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,482,830 - 213,484,517 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,482,830 - 213,484,517 (-)Ensemblpanpan1.1panPan2
CRYGC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3716,424,884 - 16,482,227 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0 Ensembl3716,367,491 - 16,379,514 (-)EnsemblROS_Cfam_1.0 Ensembl
LOC110257071
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15111,256,725 - 111,258,277 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115111,256,707 - 111,258,291 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CRYGC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,925,842 - 93,928,514 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,925,908 - 93,927,583 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,439,777 - 105,441,829 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Crygc
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSMUST00000027089, ENSMUST00000114064
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
RH138564  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,071,604 - 65,071,841UniSTSGRCm38
MGSCv37165,118,178 - 65,118,415UniSTSGRCm37
Celera165,564,809 - 65,565,046UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS
Crygc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37165,118,250 - 65,119,792UniSTSGRCm37
MGSCv37165,118,323 - 65,119,865UniSTSGRCm37
Celera165,564,881 - 65,566,424UniSTS
Celera165,564,954 - 65,566,497UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS
cM Map132.0UniSTS
Crygc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,071,749 - 65,073,291UniSTSGRCm38
MGSCv37165,118,323 - 65,119,865UniSTSGRCm37
Celera165,564,954 - 65,566,497UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS
Crygc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,071,676 - 65,073,218UniSTSGRCm38
MGSCv37165,118,250 - 65,119,792UniSTSGRCm37
Celera165,564,881 - 65,566,424UniSTS
Cytogenetic Map1C2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000027089   ⟹   ENSMUSP00000027089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,110,684 - 65,112,848 (-)Ensembl
GRCm38.p6 Ensembl165,071,525 - 65,073,689 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114064   ⟹   ENSMUSP00000109698
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,110,690 - 65,112,680 (-)Ensembl
GRCm38.p6 Ensembl165,071,531 - 65,073,521 (-)Ensembl
RefSeq Acc Id: NM_001082573   ⟹   NP_001076042
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,110,684 - 65,112,691 (-)NCBI
GRCm38165,071,525 - 65,073,532 (-)NCBI
MGSCv37165,118,105 - 65,120,095 (-)RGD
Celera165,564,730 - 65,566,738 (-)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007775   ⟹   NP_031801
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,110,684 - 65,112,691 (-)NCBI
GRCm38165,071,525 - 65,073,532 (-)NCBI
MGSCv37165,118,105 - 65,120,095 (-)RGD
Celera165,564,730 - 65,566,738 (-)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001076042   ⟸   NM_001082573
- Peptide Label: isoform 2
- UniProtKB: A3RLD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_031801   ⟸   NM_007775
- Peptide Label: isoform 1
- UniProtKB: Q03739 (UniProtKB/Swiss-Prot),   Q61597 (UniProtKB/Swiss-Prot),   A3RLD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027089   ⟸   ENSMUST00000027089
RefSeq Acc Id: ENSMUSP00000109698   ⟸   ENSMUST00000114064
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61597-F1-model_v2 AlphaFold Q61597 1-174 view protein structure

Promoters
RGD ID:6873952
Promoter ID:EPDNEW_M427
Type:multiple initiation site
Name:Crygc_1
Description:Mus musculus crystallin, gamma C , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38165,073,532 - 65,073,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88523 AgrOrtholog
Ensembl Genes ENSMUSG00000025952 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027089 ENTREZGENE
  ENSMUST00000027089.15 UniProtKB/Swiss-Prot
  ENSMUST00000114064 ENTREZGENE
  ENSMUST00000114064.3 UniProtKB/TrEMBL
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Beta/gamma_crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12966 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88523 ENTREZGENE
NCBI Gene 12966 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAMMA-CRYSTALLIN C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Crystall UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crygc PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART XTALbg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3RLD4 ENTREZGENE, UniProtKB/TrEMBL
  A3RLD5 ENTREZGENE, UniProtKB/TrEMBL
  CRGC_MOUSE UniProtKB/Swiss-Prot
  Q03739 ENTREZGENE
  Q61597 ENTREZGENE
UniProt Secondary Q03739 UniProtKB/Swiss-Prot