Slc39a12<sup>em77Tja</sup> (solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman)

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Gene: Slc39a12^em77Tja (solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman) Rattus norvegicus

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Symbol:

Slc39a12^em77Tja

Name:

solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman

RGD ID:

10401842

Description:

This allele was made by ZFN mutagenesis. The resulting mutation 77 has a stop codon, 15 amino acids from the ZFN-binding site, that resulted in a 490 amino acids (54 kDa) truncated protein, 198 amino acids smaller than the WT protein
ASSOCIATED WITH decreased pulmonary artery pressure; ASSOCIATED WITH Pulmonary Hypertension, Hypoxia-Induced ; Right Ventricular Hypertrophy

Type:

allele of Slc39a12

Previously known as:

Slc39a12^[em77Tja]; Slc39a12em77Tja

Is Marker For:

Strains: WKY-Slc39a12^em77Tja-/- WKY-Slc39a12^em77Tja WKY-Slc39a12^em77Tja+/-

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	17		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Pulmonary Hypertension, Hypoxia-Induced (IMP)

Right Ventricular Hypertrophy (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased pulmonary artery pressure (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.	Zhao L, etal., Nature. 2015 Aug 20;524(7565):356-60. doi: 10.1038/nature14620. Epub 2015 Aug 10.

Genomics

Related Rat Strains

The following Strains have been annotated to Slc39a12^em77Tja

WKY-Slc39a12^em77Tja+/- WKY-Slc39a12^em77Tja-/- WKY-Slc39a12^em77Tja

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype