Tlr9 (toll like receptor 9) - Rat Genome Database

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Gene: Tlr9 (toll like receptor 9) Chinchilla lanigera
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Symbol: Tlr9
Name: toll like receptor 9
RGD ID: 10335251
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); siRNA binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); cellular response to chloroquine (ortholog); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH Achlorhydria (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: toll-like receptor 9
RGD Orthologs
Human
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Achlorhydria  (ISO)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
anogenital venereal wart  (ISO)
asthma  (ISO)
bacterial pneumonia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic granulomatous disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISO)
Chronic Periodontitis  (ISO)
crescentic glomerulonephritis  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Granuloma, Foreign-Body  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypergammaglobulinemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
Klebsiella Infections  (ISO)
Legionnaires' disease  (ISO)
Liver Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Malarial Anemia  (ISO)
mastitis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
Oral Lichen Planus  (ISO)
papillomavirus infectious disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Pneumococcal Infections  (ISO)
Pneumococcal Meningitis  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Granuloma  (ISO)
Schistosomiasis Mansoni  (ISO)
sinusitis  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Tracheoesophageal Fistula  (ISO)
Transplant Rejection  (ISO)
Triple Negative Breast Neoplasms  (ISO)
trypanosomiasis  (ISO)
ureteral obstruction  (ISO)
viral pneumonia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
cellular response to chloroquine  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to metal ion  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to virus  (ISO)
I-kappaB kinase/NF-kappaB signaling  (ISO)
I-kappaB phosphorylation  (ISO)
immune response  (ISO)
maintenance of gastrointestinal epithelium  (ISO)
male gonad development  (ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of toll-like receptor 9 signaling pathway  (ISO)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of B cell activation  (ISO)
regulation of B cell differentiation  (ISO)
regulation of dendritic cell cytokine production  (ISO)
regulation of inflammatory response  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of toll-like receptor 9 signaling pathway  (ISO)
response to virus  (ISO)
toll-like receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Tlr9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBIChiLan1.0ChiLan1.0
TLR9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,221,080 - 52,225,645 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,221,080 - 52,225,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,255,096 - 52,259,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,230,138 - 52,235,219 (-)NCBINCBI36hg18NCBI36
Build 34352,230,137 - 52,233,247NCBI
Celera352,234,410 - 52,239,491 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,317,258 - 52,322,341 (-)NCBIHuRef
CHM1_1352,207,624 - 52,212,707 (-)NCBICHM1_1
Tlr9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,099,797 - 106,104,075 (+)NCBIGRCm39mm39
GRCm39 Ensembl9106,099,797 - 106,104,082 (+)Ensembl
GRCm389106,222,598 - 106,226,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,222,598 - 106,226,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,124,929 - 106,129,207 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,080,699 - 106,084,977 (+)NCBImm8
Celera9105,848,890 - 105,853,167 (+)NCBICelera
Cytogenetic Map9F1NCBI
Tlr9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28106,864,680 - 106,868,796 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl8114,916,122 - 114,920,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08114,916,122 - 114,920,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08114,279,020 - 114,283,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8106,185,754 - 106,189,869 (+)NCBICelera
Cytogenetic Map8q32NCBI
TLR9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,529,322 - 37,547,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,542,340 - 37,547,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,529,401 - 37,539,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,510,887 - 37,521,504 (+)NCBI
Dog10K_Boxer_Tasha2037,523,889 - 37,528,666 (+)NCBI
ROS_Cfam_1.02037,879,856 - 37,897,682 (+)NCBI
UMICH_Zoey_3.12037,256,577 - 37,261,354 (+)NCBI
UMICH_Zoey_3.12037,243,558 - 37,254,192 (+)NCBI
UNSW_CanFamBas_1.02037,652,111 - 37,662,740 (+)NCBI
UNSW_CanFamBas_1.02037,665,125 - 37,669,902 (+)NCBI
UU_Cfam_GSD_1.02037,936,949 - 37,947,576 (+)NCBI
UU_Cfam_GSD_1.02037,950,172 - 37,954,949 (+)NCBI
TLR9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11334,353,444 - 34,370,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,634,343 - 37,652,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005410346   ⟹   XP_005410403
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013507652   ⟹   XP_013363106
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013507653   ⟹   XP_013363107
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005410403 (Get FASTA)   NCBI Sequence Viewer  
  XP_013363106 (Get FASTA)   NCBI Sequence Viewer  
  XP_013363107 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013363107   ⟸   XM_013507653
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013363106   ⟸   XM_013507652
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005410403   ⟸   XM_005410346
- Peptide Label: isoform X1
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010935 ENTREZGENE
Ensembl Protein ENSCLAP00000015895 ENTREZGENE
Ensembl Transcript ENSCLAT00000016059 ENTREZGENE
NCBI Gene Tlr9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tlr9  toll like receptor 9    toll-like receptor 9  Symbol and/or name change 5135510 APPROVED