Gene: Add2 (adducin 2 (beta)) Mus musculus
Analyze
Symbol:
Add2
Name:
adducin 2 (beta)
Description:
A structural constituent of cytoskeleton. Involved in hemopoiesis and synapse assembly. Localizes to the membrane and postsynaptic density. Used to study hereditary spherocytosis type 1. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Is expressed in several structures, including central nervous system; liver; retina; spinal ganglion; and turbinate bone primordium. Orthologous to human ADD2 (adducin 2).
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
2900072M03Rik; add97; beta-adducin; erythrocyte adducin subunit beta; snoRNA MBII-396
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ADD2 (adducin 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Add2 (adducin 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Add2 (adducin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ADD2 (adducin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ADD2 (adducin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Add2 (adducin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ADD2 (adducin 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ADD1 (adducin 1) HGNC
OrthoMCL
Homo sapiens (human):
ADD3 (adducin 3) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Add2 (adducin 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ADD2 (adducin 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
add2 (adducin 2 (beta))
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
add-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
hts
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 6 86,028,681 - 86,124,409 (+) Ensembl GRCm38 6 86,028,681 - 86,124,409 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 86,028,078 - 86,069,549 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 86,043,718 - 86,085,189 (+) NCBI mm8 Celera 6 87,962,737 - 88,060,519 (+) NCBI Celera Cytogenetic Map 6 C3-D1 NCBI cM Map 6 37.55 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - Genetic Association Database
hypertension ISO RGD:736575 1331525 GAD
Imported Annotations - MGI
hereditary spherocytosis type 1 IEA 13592920 OMIM:182900 MouseDO
1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of ADD2 mRNA CTD PMID:26682919 1-naphthyl isothiocyanate decreases expression ISO RGD:2042 6480464 1-Naphthylisothiocyanate results in decreased expression of ADD2 mRNA CTD PMID:30723492 17beta-estradiol multiple interactions ISO RGD:736575 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of ADD2 mRNA CTD PMID:30165855 2-butoxyethanol increases expression EXP 6480464 n-butoxyethanol results in increased expression of ADD2 mRNA CTD PMID:19812364 3,3',5-triiodo-L-thyronine increases expression ISO RGD:736575 6480464 Triiodothyronine results in increased expression of ADD2 mRNA CTD PMID:23397585 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ADD2 mRNA CTD PMID:20188158 4,4'-sulfonyldiphenol decreases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of ADD2 mRNA CTD PMID:30951980 6-propyl-2-thiouracil increases expression ISO RGD:2042 6480464 Propylthiouracil results in increased expression of ADD2 mRNA CTD PMID:24780913 acrylamide decreases expression ISO RGD:2042 6480464 Acrylamide results in decreased expression of ADD2 mRNA CTD PMID:28959563 aflatoxin B2 increases methylation ISO RGD:736575 6480464 aflatoxin B2 results in increased methylation of ADD2 intron CTD PMID:30157460 ammonium chloride affects expression ISO RGD:2042 6480464 Ammonium Chloride affects the expression of ADD2 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:736575 6480464 Antirheumatic Agents results in decreased expression of ADD2 mRNA CTD PMID:24449571 benzo[a]pyrene increases expression ISO RGD:736575 6480464 Benzo(a)pyrene results in increased expression of ADD2 mRNA CTD PMID:30453624 bisphenol A decreases expression ISO RGD:2042 6480464 bisphenol A results in decreased expression of ADD2 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:2042 6480464 bisphenol A results in increased expression of ADD2 mRNA CTD PMID:30816183 butanal increases expression ISO RGD:736575 6480464 butyraldehyde results in increased expression of ADD2 mRNA CTD PMID:26079696 carbonyl sulfide decreases expression ISO RGD:2042 6480464 carbonyl sulfide results in decreased expression of ADD2 mRNA CTD PMID:19395590 copper atom increases expression ISO RGD:2042 6480464 Copper deficiency results in increased expression of ADD2 mRNA CTD PMID:26033743 copper atom multiple interactions ISO RGD:2042 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of ADD2 mRNA CTD PMID:26033743 copper(0) increases expression ISO RGD:2042 6480464 Copper deficiency results in increased expression of ADD2 mRNA CTD PMID:26033743 copper(0) multiple interactions ISO RGD:2042 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of ADD2 mRNA CTD PMID:26033743 daidzein multiple interactions ISO RGD:736575 6480464 [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA CTD PMID:16963248 dorsomorphin multiple interactions ISO RGD:736575 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:736575 6480464 Doxorubicin results in decreased expression of ADD2 mRNA CTD PMID:29803840 endosulfan decreases expression ISO RGD:2042 6480464 Endosulfan results in decreased expression of ADD2 mRNA CTD PMID:29391264 genistein multiple interactions ISO RGD:736575 6480464 [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA CTD PMID:16963248 glycitein multiple interactions ISO RGD:736575 6480464 [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of ADD2 mRNA CTD PMID:16963248 graphite affects expression ISO RGD:2042 6480464 Graphite affects the expression of ADD2 mRNA CTD PMID:29933104 ketamine decreases expression ISO RGD:2042 6480464 Ketamine results in decreased expression of ADD2 mRNA CTD PMID:20080153 manganese(II) chloride increases expression ISO RGD:2042 6480464 manganese chloride results in increased expression of ADD2 mRNA CTD PMID:28801915 methamphetamine increases expression ISO RGD:2042 6480464 Methamphetamine results in increased expression of ADD2 mRNA CTD PMID:19564919 oxaliplatin multiple interactions ISO RGD:2042 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ADD2 mRNA CTD PMID:25729387 phenylmercury acetate decreases expression ISO RGD:736575 6480464 Phenylmercuric Acetate results in decreased expression of ADD2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736575 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADD2 mRNA CTD PMID:27188386 potassium dichromate affects expression EXP 6480464 Potassium Dichromate affects the expression of ADD2 mRNA CTD PMID:23608068 SB 431542 multiple interactions ISO RGD:736575 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:736575 6480464 Silicon Dioxide analog results in increased expression of ADD2 mRNA CTD PMID:25895662 sodium arsenite affects methylation ISO RGD:736575 6480464 sodium arsenite affects the methylation of ADD2 gene CTD PMID:28589171 tert-butyl hydroperoxide increases expression ISO RGD:736575 6480464 tert-Butylhydroperoxide results in increased expression of ADD2 mRNA CTD PMID:15336504 tetrachloromethane decreases expression ISO RGD:2042 6480464 Carbon Tetrachloride results in decreased expression of ADD2 mRNA CTD PMID:30723492 titanium dioxide decreases expression ISO RGD:2042 6480464 titanium dioxide results in decreased expression of ADD2 mRNA CTD PMID:30012374 topotecan multiple interactions ISO RGD:2042 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ADD2 mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:2042 6480464 Topotecan results in decreased expression of ADD2 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO RGD:736575 6480464 trichostatin A results in decreased expression of ADD2 mRNA CTD PMID:24935251 valproic acid increases expression ISO RGD:736575 6480464 Valproic Acid results in increased expression of ADD2 mRNA CTD PMID:19101580 valproic acid decreases methylation ISO RGD:736575 6480464 Valproic Acid results in decreased methylation of ADD2 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:736575 6480464 Valproic Acid results in decreased expression of ADD2 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:736575 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADD2 mRNA CTD PMID:27188386 vorinostat multiple interactions ISO RGD:736575 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADD2 mRNA CTD PMID:27188386
Biological Process actin filament bundle assembly ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 actin filament bundle assembly IBA PANTHER:PTN000072560 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 barbed-end actin filament capping ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 barbed-end actin filament capping IBA PANTHER:PTN000072560 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 hemopoiesis IMP MGI:MGI:2149065 2290270 (MGI:MGI:2149009, PMID:10485892) MGI MGI:MGI:2149009 , PMID:10485892 ion transport ISO RGD:2042 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 leukocyte migration ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 leukocyte tethering or rolling ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of protein binding ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex assembly ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 synapse assembly IMP 2290270 (MGI:MGI:5140673, PMID:21435558) MGI MGI:MGI:5140673 , PMID:21435558 synapse assembly IDA 2290270 (MGI:MGI:5140673, PMID:21435558) MGI MGI:MGI:5140673 , PMID:21435558 Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoplasmic vesicle ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoskeleton IBA MGI:MGI:1351615 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 F-actin capping protein complex ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 glutamatergic synapse ISO RGD:2042 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 membrane IDA 2290270 (MGI:MGI:2149009, PMID:10485892) MGI MGI:MGI:2149009 , PMID:10485892 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 plasma membrane raft ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 plasma membrane raft IBA PANTHER:PTN000072560 , UniProtKB:P35612 2290270 (PMID:21873635) GO_Central PMID:21873635 postsynapse ISO RGD:2042 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 postsynaptic density IDA 2290270 (MGI:MGI:5436301, PMID:17114649) MGI MGI:MGI:5436301 , PMID:17114649 postsynaptic density IBA MGI:MGI:1351615 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function actin binding ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 actin filament binding ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 actin filament binding IBA PANTHER:PTN000072560 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 calmodulin binding IEA UniProtKB-KW:KW-0112 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein heterodimerization activity ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein homodimerization activity ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein kinase binding ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 spectrin binding ISO UniProtKB:P35612 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 spectrin binding IBA PANTHER:PTN000072560 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 structural constituent of cytoskeleton IDA 2290270 (MGI:MGI:2149009, PMID:10485892) MGI MGI:MGI:2149009 , PMID:10485892
Gene-Chemical Interaction Annotations
