CBSL (cystathionine beta-synthase like) - Rat Genome Database

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Gene: CBSL (cystathionine beta-synthase like) Homo sapiens
Analyze
No known orthologs.
Symbol: CBSL (Ensembl: CBS)
Name: cystathionine beta-synthase like (Ensembl:cystathionine beta-synthase)
RGD ID: 10054187
Description: ENCODES a protein that exhibits carbon monoxide binding; cystathionine beta-synthase activity; enzyme binding; INVOLVED IN cysteine biosynthetic process; DNA protection; homocysteine catabolic process; FOUND IN cytoplasm; nucleus
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-thionase; CBS; cystathionine beta-synthase; cystathionine-beta-synthase like; serine sulfhydrase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GeneID:102724560 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:875. [11 Jun 2021]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38216,444,869 - 6,468,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,053,191 - 43,076,943 (-)EnsemblGRCh38hg38GRCh38
Cytogenetic Map21p12NCBI
T2T-CHM13v2.02141,444,310 - 41,468,059 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (HDA,TAS)
nucleus  (IDA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7929220   PMID:11483494   PMID:12477932   PMID:15520012   PMID:16189514   PMID:16780588   PMID:17087506   PMID:18776696   PMID:19010420   PMID:19447967   PMID:20031578   PMID:21653829  
PMID:21873635   PMID:21900206   PMID:22985361   PMID:23981774   PMID:24416422   PMID:24515102   PMID:24534463   PMID:25416956   PMID:25502805   PMID:29117863   PMID:29410458   PMID:30463901  
PMID:31515488   PMID:31586073   PMID:31620119   PMID:32296183   PMID:32807901   PMID:32814053   PMID:32994395   PMID:34728620   PMID:36168627  


Genomics


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2276 4396 5012 4134 9403 3112 4219 5 1042 2656 730 4191 11857 11033 93 7271 1372 3108 2974 332 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001321073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017028209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017028210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047440657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ005135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX069344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP236240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000398168   ⟹   ENSP00000381234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,444,869 - 6,467,513 (-)Ensembl
Ensembl Acc Id: ENST00000617706   ⟹   ENSP00000481719
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,444,873 - 6,468,040 (-)Ensembl
Ensembl Acc Id: ENST00000618024   ⟹   ENSP00000479559
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,444,869 - 6,468,040 (-)Ensembl
Ensembl Acc Id: ENST00000622914
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,447,132 - 6,467,534 (-)Ensembl
Ensembl Acc Id: ENST00000623939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,456,880 - 6,461,713 (-)Ensembl
Ensembl Acc Id: ENST00000624406   ⟹   ENSP00000485669
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,444,869 - 6,467,509 (-)Ensembl
Ensembl Acc Id: ENST00000624691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,444,869 - 6,460,082 (-)Ensembl
Ensembl Acc Id: ENST00000624808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,447,261 - 6,450,632 (-)Ensembl
Ensembl Acc Id: ENST00000624921
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,457,901 - 6,467,483 (-)Ensembl
Ensembl Acc Id: ENST00000624934   ⟹   ENSP00000485527
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,445,433 - 6,467,532 (-)Ensembl
RefSeq Acc Id: NM_001321073   ⟹   NP_001308002
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,547 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354006   ⟹   NP_001340935
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,621 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,468,059 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354007   ⟹   NP_001340936
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,621 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,468,059 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354008   ⟹   NP_001340937
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,547 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354009   ⟹   NP_001340938
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,513 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,466,951 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354010   ⟹   NP_001340939
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,623 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,061 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354012   ⟹   NP_001340941
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,197 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,466,635 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354014   ⟹   NP_001340943
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,623 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,061 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354015   ⟹   NP_001340944
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,623 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,061 (-)NCBI
Sequence:
RefSeq Acc Id: NR_148682
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,623 (-)NCBI
T2T-CHM13v2.02141,444,310 - 41,467,061 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017028209   ⟹   XP_016883698
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,460,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017028210   ⟹   XP_016883699
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,460,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047440649   ⟹   XP_047296605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,502 (-)NCBI
RefSeq Acc Id: XM_047440650   ⟹   XP_047296606
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
RefSeq Acc Id: XM_047440651   ⟹   XP_047296607
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,621 (-)NCBI
RefSeq Acc Id: XM_047440652   ⟹   XP_047296608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,621 (-)NCBI
RefSeq Acc Id: XM_047440653   ⟹   XP_047296609
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
RefSeq Acc Id: XM_047440654   ⟹   XP_047296610
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,502 (-)NCBI
RefSeq Acc Id: XM_047440655   ⟹   XP_047296611
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
RefSeq Acc Id: XM_047440656   ⟹   XP_047296612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,468,109 (-)NCBI
RefSeq Acc Id: XM_047440657   ⟹   XP_047296613
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,444,869 - 6,467,502 (-)NCBI
RefSeq Acc Id: XP_016883699   ⟸   XM_017028210
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001308002   ⟸   NM_001321073
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016883698   ⟸   XM_017028209
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001340936   ⟸   NM_001354007
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340935   ⟸   NM_001354006
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340937   ⟸   NM_001354008
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340939   ⟸   NM_001354010
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340938   ⟸   NM_001354009
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340944   ⟸   NM_001354015
- Peptide Label: isoform b
- UniProtKB: B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340943   ⟸   NM_001354014
- Peptide Label: isoform b
- UniProtKB: B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001340941   ⟸   NM_001354012
- Peptide Label: isoform a
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot),   B7Z2D6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000381234   ⟸   ENST00000398168
Ensembl Acc Id: ENSP00000485669   ⟸   ENST00000624406
Ensembl Acc Id: ENSP00000485527   ⟸   ENST00000624934
Ensembl Acc Id: ENSP00000481719   ⟸   ENST00000617706
Ensembl Acc Id: ENSP00000479559   ⟸   ENST00000618024
RefSeq Acc Id: XP_047296607   ⟸   XM_047440651
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047296608   ⟸   XM_047440652
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047296606   ⟸   XM_047440650
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047296612   ⟸   XM_047440656
- Peptide Label: isoform X3
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047296609   ⟸   XM_047440653
- Peptide Label: isoform X3
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047296611   ⟸   XM_047440655
- Peptide Label: isoform X3
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047296613   ⟸   XM_047440657
- Peptide Label: isoform X3
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047296610   ⟸   XM_047440654
- Peptide Label: isoform X3
- UniProtKB: Q99425 (UniProtKB/Swiss-Prot),   P35520 (UniProtKB/Swiss-Prot),   D3DSK4 (UniProtKB/Swiss-Prot),   B2R993 (UniProtKB/Swiss-Prot),   Q9BWC5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047296605   ⟸   XM_047440649
- Peptide Label: isoform X2
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DN79-F1-model_v2 AlphaFold P0DN79 1-551 view protein structure
AF-P35520-F1-model_v2 AlphaFold P35520 1-551 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:51829 AgrOrtholog
COSMIC CBSL COSMIC
Ensembl Genes ENSG00000160200 Ensembl, UniProtKB/Swiss-Prot
  ENSG00000274276 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000352178.9 UniProtKB/Swiss-Prot
  ENST00000359624.7 UniProtKB/Swiss-Prot
  ENST00000398158.5 UniProtKB/Swiss-Prot
  ENST00000398165.8 UniProtKB/Swiss-Prot
  ENST00000398168 ENTREZGENE
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot
  3.40.50.1100 UniProtKB/Swiss-Prot
GTEx ENSG00000160200 GTEx
  ENSG00000274276 GTEx
Human Proteome Map CBSL Human Proteome Map
InterPro CBS_C UniProtKB/Swiss-Prot
  CBS_dom UniProtKB/Swiss-Prot
  CBS_dom_sf UniProtKB/Swiss-Prot
  Cys_Synth/Cystath_Beta-Synth UniProtKB/Swiss-Prot
  Cysta_beta_synth UniProtKB/Swiss-Prot
  P-phosphate_BS UniProtKB/Swiss-Prot
  PLP-dep UniProtKB/Swiss-Prot
  Trypto_synt_PLP_dependent UniProtKB/Swiss-Prot
KEGG Report hsa:102724560 UniProtKB/Swiss-Prot
  hsa:875 UniProtKB/Swiss-Prot
NCBI Gene CBSL ENTREZGENE
PANTHER CYSTATHIONINE BETA-SYNTHASE UniProtKB/Swiss-Prot
  CYSTATHIONINE BETA-SYNTHASE UniProtKB/Swiss-Prot
Pfam CBS UniProtKB/Swiss-Prot
  PALP UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
  CYS_SYNTHASE UniProtKB/Swiss-Prot
SMART CBS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53686 UniProtKB/Swiss-Prot
  SSF54631 UniProtKB/Swiss-Prot
UniProt B2R993 ENTREZGENE
  B7Z2D6 ENTREZGENE
  CBS_HUMAN UniProtKB/Swiss-Prot
  D3DSK4 ENTREZGENE
  P35520 ENTREZGENE
  Q99425 ENTREZGENE
  Q9BWC5 ENTREZGENE
UniProt Secondary B2R993 UniProtKB/Swiss-Prot
  D3DSK4 UniProtKB/Swiss-Prot
  Q99425 UniProtKB/Swiss-Prot
  Q9BWC5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-16 CBSL  cystathionine beta-synthase like  CBSL  cystathionine-beta-synthase like  Symbol and/or name change 5135510 APPROVED