Malrd1 (MAM and LDL receptor class A domain containing 1) - Rat Genome Database

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Gene: Malrd1 (MAM and LDL receptor class A domain containing 1) Mus musculus
Analyze
Symbol: Malrd1
Name: MAM and LDL receptor class A domain containing 1
RGD ID: 10053762
MGI Page MGI
Description: Acts upstream of or within cholesterol homeostasis and negative regulation of bile acid biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system and small intestine. Orthologous to human MALRD1 (MAM and LDL receptor class A domain containing 1); INTERACTS WITH aflatoxin B1 (ortholog); antirheumatic drug (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Diet; Diet1; Gm13318; Gm13364; MAM and LDL-receptor class A domain-containing protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39215,531,290 - 16,260,368 (+)NCBIGRCm39mm39
GRCm39 Ensembl215,531,290 - 16,260,366 (+)Ensembl
GRCm38215,526,479 - 16,255,557 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl215,526,479 - 16,255,555 (+)EnsemblGRCm38mm10GRCm38
Celera215,429,298 - 16,159,403 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map25.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10744778   PMID:11682476   PMID:18799693   PMID:21677750   PMID:23747249   PMID:24316575   PMID:26045262   PMID:29295820   PMID:32325033  


Genomics

Comparative Map Data
Malrd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39215,531,290 - 16,260,368 (+)NCBIGRCm39mm39
GRCm39 Ensembl215,531,290 - 16,260,366 (+)Ensembl
GRCm38215,526,479 - 16,255,557 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl215,526,479 - 16,255,555 (+)EnsemblGRCm38mm10GRCm38
Celera215,429,298 - 16,159,403 (+)NCBICelera
Cytogenetic Map2A2NCBI
cM Map25.8NCBI
MALRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1019,048,801 - 19,790,401 (+)EnsemblGRCh38hg38GRCh38
GRCh381019,046,931 - 19,734,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371019,337,730 - 20,023,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361019,585,919 - 19,820,636 (+)NCBINCBI36hg18NCBI36
Celera1019,077,832 - 19,709,527 (+)NCBI
Cytogenetic Map10p12.31NCBI
HuRef1018,999,191 - 19,687,579 (+)NCBIHuRef
CHM1_11019,337,662 - 20,023,348 (+)NCBICHM1_1
Malrd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21778,418,819 - 79,131,016 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1778,418,819 - 79,131,016 (+)Ensembl
Rnor_6.01782,430,836 - 83,156,696 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1782,430,836 - 82,953,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01784,168,046 - 84,892,095 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41789,607,379 - 89,780,519 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1777,741,837 - 78,442,699 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
Malrd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554298,634,944 - 9,235,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554298,634,713 - 9,235,666 (-)NCBIChiLan1.0ChiLan1.0
MALRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11019,573,166 - 20,185,006 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01019,461,865 - 19,886,155 (+)NCBIMhudiblu_PPA_v0panPan3
LOC608668
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1213,151,316 - 13,904,122 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2519,960,641 - 20,225,118 (-)NCBI
Malrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934419,434,202 - 20,034,532 (+)NCBI
SpeTri2.0NW_0049365207,926,273 - 8,504,777 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MALRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11054,782,806 - 55,381,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21060,986,398 - 61,270,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MALRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1918,964,693 - 19,640,356 (+)NCBI
Vero_WHO_p1.0NW_02366605124,657,503 - 25,353,844 (+)NCBI
Malrd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247968,383,901 - 9,074,860 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045633Heal15_mwound healing/regeneration 15 (mouse)Not determined2121984831Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125319748Mouse
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125319748Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126524778Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323390328289138Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2778910341789249Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2834628442346384Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2841803942418228Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2949443443494563Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2949443443494563Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967188027132630Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212472666726109Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21432455548324701Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:39
Interacting mature miRNAs:39
Transcripts:ENSMUST00000146205
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000146205   ⟹   ENSMUSP00000116869
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl215,531,290 - 16,260,366 (+)Ensembl
GRCm38.p6 Ensembl215,526,479 - 16,255,555 (+)Ensembl
RefSeq Acc Id: NM_001310455   ⟹   NP_001297384
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39215,531,290 - 16,260,368 (+)NCBI
GRCm38215,526,479 - 16,255,557 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001297384 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2AJX4 (Get FASTA)   NCBI Sequence Viewer  
  AGN95783 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001297384   ⟸   NM_001310455
- Peptide Label: precursor
- UniProtKB: A2AJX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000116869   ⟸   ENSMUST00000146205
Protein Domains
EGF-like   LDL-receptor class A   MAM

Promoters
RGD ID:6876404
Promoter ID:EPDNEW_M1653
Type:multiple initiation site
Name:Malrd1_1
Description:Mus musculus MAM and LDL receptor class A domain containing 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38215,526,501 - 15,526,561EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928271 AgrOrtholog
Ensembl Genes ENSMUSG00000075520 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000116869 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000146205 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.400.10 UniProtKB/Swiss-Prot
InterPro ConA-like_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
  MAM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:102635496 UniProtKB/Swiss-Prot
MGD MGI:1928271 ENTREZGENE
NCBI Gene Malrd1 ENTREZGENE
Pfam Ldl_recept_a UniProtKB/Swiss-Prot
  MAM UniProtKB/Swiss-Prot
PhenoGen Malrd1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
  MAMDOMAIN UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  MAM_2 UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  MAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
UniProt A2AJX4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary R9W764 UniProtKB/Swiss-Prot