Cell Line : CVCL_4V90 (RPMI-8226/MR4) Homo sapiens
Symbol:	CVCL_4V90
Name:	RPMI-8226/MR4
RGD ID:	21188974
Cell Line Type:	cancer cell line
Origin:	Population: African American; Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone; Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178; Cell type: B-cell; CL=CL_0000236.
Gender:	Male
Characteristics:	Characteristics: Produces IgG lambda (from parent cell line)
Genomic Alteration:	Sequence variation: Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line); Sequence variation: Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line); Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line)
Derived From Cell Lines:	CVCL_0014 (RPMI-8226)
Child Cell Lines:	CVCL_0509 (RPMI-8226/MR20)
Aliases:	8226/MR4; RPMI 8226/MR4
Disease(s):	multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

Additional References at PubMed

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PMID:10070958

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External Database Links

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Database	Acc Id	Source(s)
cancercelllines	CVCL_4V90	CELLOSAURUS
Cellosaurus	CVCL_4V90	CELLOSAURUS
NCIt	C3242	CELLOSAURUS
Orphanet	29073	CELLOSAURUS
Wikidata	Q54951251	CELLOSAURUS

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