CVCL_WR44 - Rat Genome Database

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Cell Line : CVCL_WR44 (HL-60/AR) Homo sapiens

Symbol: CVCL_WR44
Name: HL-60/AR
RGD ID: 21185350
Cell Line Type: cancer cell line
Origin: Selected for resistance to: ChEBI; CHEBI:48120; Anthracycline; Derived from sampling site: Peripheral blood.
Gender: Female
Genomic Alteration: Sequence variation: Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (ClinVar=VCV000009409) (from parent cell line); Sequence variation: Heterozygous for NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (from parent cell line); Sequence variation: Gene deletion; TP53; Zygosity=Homozygous (from parent cell line)
Caution: Caution: Not to be confused with HL60/AR (CVCL_WI27) which is an 5-azacytidine resistant subline of HL-60
Groups: Group: Space-flown cell line (cellonaut)
Notes: Anecdotal: Have been flown in space on shuttle flight STS-67 to study the effect of microgravity on multidrug resistance (PubMed=9434637)
Derived From Cell Lines: CVCL_0002 (HL-60)

Additional References at PubMed
PMID:2545346   PMID:3860286   PMID:9434637  

Additional Information

Database Acc Id Source(s)
Orphanet 519 CELLOSAURUS
Wikidata Q94211566 CELLOSAURUS