CVCL_VR67 - Rat Genome Database

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Cell Line : CVCL_VR67 (MDA-MB-231 VIM RFP) Homo sapiens

Symbol: CVCL_VR67
Name: MDA-MB-231 VIM RFP
RGD ID: 21171842
Cell Line Type: cancer cell line
Origin: Derived from metastatic site: Pleural effusion.
Gender: Female
Characteristics: Characteristics: A red fluorescent protein (RFP) tag was added to the C-terminal of the VIM gene by CRISPR/Cas9 Allows to monitor the epithelial-to-mesenchymal transition (EMT) status of cells in vitro by monitoring RFP expression.
Genomic Alteration: Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line); Transfected with: UniProtKB; Q9U6Y8; RFP
Groups: Group: Triple negative breast cancer (TNBC) cell line
Derived From Cell Lines: CVCL_0062 (MDA-MB-231)
Disease(s): breast adenocarcinoma (DOID:3458) [NCI:C5214]

References

Additional Information

Database Acc Id Source(s)
ATCC HTB-26MET CELLOSAURUS
Cellosaurus CVCL_VR67 CELLOSAURUS
NCIt C5214 CELLOSAURUS
Wikidata Q95987359 CELLOSAURUS