CVCL_3428 - Rat Genome Database

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Cell Line : CVCL_3428 (U87/DK) Homo sapiens

Symbol: CVCL_3428
Name: U87/DK
RGD ID: 21164804
Cell Line Type: cancer cell line
Gender: Male
Genomic Alteration: Sequence variation: Heterozygous for NF1 p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT) (ClinVar=VCV000420078) (from parent cell line); Sequence variation: Homozygous for PTEN c.209+1G>T (ClinVar=VCV000229705); Note=Splice donor mutation (from parent cell line); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Transfected with: HGNC; 3236; EGFR (with p.Val30_Arg297del and pLys745Met = EGFRvIII and dead kinase).
Caution: Problematic cell line: Misidentified Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Related Genes: EGFR  
Derived From Cell Lines: CVCL_0022 (U-87MG ATCC)
Aliases: U87 dead kinase; U87-DK; U87DK; U87MG.deltaEGFR DK; U87MG.DK
Disease(s): glioblastoma (DOID:3068) [NCI:C3058]

Additional References at PubMed
PMID:8810340   PMID:9006938  

Additional Information

Database Acc Id Source(s)
Cellosaurus CVCL_3428 CELLOSAURUS
Orphanet 360 CELLOSAURUS
Wikidata Q54973750 CELLOSAURUS