CVCL_2219 - Rat Genome Database

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Cell Line : CVCL_2219 (U-373MG ATCC) Homo sapiens

Symbol: CVCL_2219
Name: U-373MG ATCC
RGD ID: 21150197
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Brain; parietal lobe.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: Deep exome analysis; Omics: Deep RNAseq analysis; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: ATCC; HTB-17; true; Discontinued: ECACC; 89081403; true; Discontinued: JCRB; NIHS0295; true
Genomic Alteration: Sequence variation: PTEN p.Glu242Valfs*15 (c.723_724dupTG) (ClinVar=VCV000536553) (from parent cell line); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Sequence variation: Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (PubMed=10416987; PubMed=14614447)
Caution: Problematic cell line: Misidentified/contaminated Shown to be a U-251MG derivative. This cell line is not the original astrocytoma cell line established in 1973 at the University of Uppsala. See U-373MG Uppsala (CVCL_2818) for the original U-373MG cell line.
Groups: Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00295
Derived From Cell Lines: CVCL_0021 (U-251MG)
Child Cell Lines: CVCL_1F84 (U373-MAGI)
Aliases: 373 MG; 373MG; U-373 MG; U-373-MG; U-373MG; U373; U373 MG; U373-MG; U373MG
Disease(s): autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]
malignant astrocytoma (DOID:3069) [NCI:C60781]

References
Additional References at PubMed
PMID:450131   PMID:833871   PMID:2253244   PMID:3518877   PMID:6220172   PMID:6260907   PMID:6582512   PMID:8858520   PMID:9220028   PMID:10074188   PMID:10416987   PMID:11351043  
PMID:11414198   PMID:14614447   PMID:16232199   PMID:16697959   PMID:20215515   PMID:20593219   PMID:21406405   PMID:22282976   PMID:22570425   PMID:26496030  


Additional Information

Database Acc Id Source(s)
ATCC HTB-17 CELLOSAURUS
BTO BTO_0002126 CELLOSAURUS
Cell Line Ontology CLO_0009460 CELLOSAURUS
  CLO_0009461 CELLOSAURUS
Cellosaurus CVCL_2219 CELLOSAURUS
ChEMBL-Cells CHEMBL3307474 CELLOSAURUS
ChEMBL-Targets CHEMBL615024 CELLOSAURUS
COSMIC Samples 1066236 CELLOSAURUS
  1171226 CELLOSAURUS
  1175824 CELLOSAURUS
  1217674 CELLOSAURUS
  1294952 CELLOSAURUS
  1610742 CELLOSAURUS
  2367504 CELLOSAURUS
  2491105 CELLOSAURUS
  2701087 CELLOSAURUS
  687589 CELLOSAURUS
  849849 CELLOSAURUS
  850825 CELLOSAURUS
  920819 CELLOSAURUS
  970093 CELLOSAURUS
ECACC 89081403 CELLOSAURUS
EFO EFO_0001255 CELLOSAURUS
GEO GSM101681 CELLOSAURUS
  GSM101682 CELLOSAURUS
  GSM827314 CELLOSAURUS
JCRB NIHS0295 CELLOSAURUS
KCLB 30017 CELLOSAURUS
LINCS_LDP LCL-1360 CELLOSAURUS
Lonza 1006 CELLOSAURUS
  334 CELLOSAURUS
NCIt C60781 CELLOSAURUS
Orphanet 94 CELLOSAURUS
PRIDE PXD000430 CELLOSAURUS
Progenetix CVCL_2219 CELLOSAURUS
Wikidata Q54973575 CELLOSAURUS