CVCL_2162 - Rat Genome Database

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Cell Line : CVCL_2162 (PLB-985) Homo sapiens

Symbol: CVCL_2162
Name: PLB-985
RGD ID: 21149810
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Female
Research Use: Omics: Deep exome analysis; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Phenotype: Doubling time: 35 hours (PubMed=25984343); ~24 hours (DSMZ)
Genomic Alteration: Sequence variation: Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (ClinVar=VCV000009409) (CCLE); Sequence variation: Heterozygous for NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (CCLE); Sequence variation: Gene deletion; TP53; Zygosity=Homozygous (from parent cell line)
Caution: Problematic cell line: Contaminated Shown to be a HL-60 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from a 38 year old female patient with acute nonlymphocytic leukemia.
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00258
Description: Genome ancestry: African=0.99%; Native American=0%; East Asian, North=1.35%; East Asian, South=0%; South Asian=0%; European, North=69.55%; European, South=28.11% (PubMed=30894373)
Derived From Cell Lines: CVCL_0002 (HL-60)
Aliases: PLB 985; PLB985

References
Additional References at PubMed
PMID:3475136   PMID:12592342   PMID:20143388   PMID:20215515   PMID:25984343   PMID:30894373   PMID:31068700  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-38 CELLOSAURUS
BioSample SAMN03151776 CELLOSAURUS
  SAMN10989584 CELLOSAURUS
BTO BTO_0002908 CELLOSAURUS
Cell Line Ontology CLO_0008457 CELLOSAURUS
Cell Model Passports SIDM00811 CELLOSAURUS
Cellosaurus CVCL_2162 CELLOSAURUS
COSMIC Samples 1089520 CELLOSAURUS
  787475 CELLOSAURUS
DepMap ACH-000034 CELLOSAURUS
DSMZ ACC-139 CELLOSAURUS
EFO EFO_0002313 CELLOSAURUS
GEO GSM1446750 CELLOSAURUS
IGRhCellID PLB985 CELLOSAURUS
Lonza 281 CELLOSAURUS
NCIt C9154 CELLOSAURUS
Orphanet 519 CELLOSAURUS
Progenetix CVCL_2162 CELLOSAURUS
Wikidata Q54947571 CELLOSAURUS