Cell Line : CVCL_LB07 (PathHunter U2OS P2RY12 Total GPCR Internalization) Homo sapiens
Symbol:
CVCL_LB07
Name:
PathHunter U2OS P2RY12 Total GPCR Internalization
RGD ID:
21148499
Cell Line Type:
cancer cell line
Origin:
Population: Caucasian; Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Gender:
Female
Characteristics:
Characteristics: PathHunter total GPCR internalization cell lines co-express a tagged with a beta-galactosidase fragment (ProLink=PK) and a second beta-galactosidase fragment (Enzyme Acceptor=EA) localized to the endosomes Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.