CVCL_LA62 - Rat Genome Database

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Cell Line : CVCL_LA62 (PathHunter U2OS HTR5A beta-arrestin) Homo sapiens

Symbol: CVCL_LA62
Name: PathHunter U2OS HTR5A beta-arrestin
RGD ID: 21148231
Cell Line Type: cancer cell line
Origin: Population: Caucasian; Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Gender: Female
Characteristics: Characteristics: PathHunter beta-arrestin cell lines co-express a GPCR tagged with a beta-galactosidase fragment (ProLink=PK) and a beta-arrestin tagged with another fragment (Enzyme Acceptor=EA) Activation of the GPCR-PK induces beta-arrestin-EA recruitment and complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
Genomic Alteration: Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line); Transfected with: HGNC; 5300; HTR5A; Transfected with: HGNC; 712; ARRB2
Related Genes: ARRB2   HTR5A  
Derived From Cell Lines: CVCL_0042 (U2OS)
Disease(s): osteosarcoma (DOID:3347) [NCI:C9145,ORDO:668]

References

Additional Information

Database Acc Id Source(s)
Cellosaurus CVCL_LA62 CELLOSAURUS
DiscoverX 93-0700C3 CELLOSAURUS
NCIt C9145 CELLOSAURUS
Orphanet 668 CELLOSAURUS
Wikidata Q54938189 CELLOSAURUS