CVCL_1G29 - Rat Genome Database

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Cell Line : CVCL_1G29 (U251-TR3) Homo sapiens

Symbol: CVCL_1G29
Name: U251-TR3
RGD ID: 21146156
Cell Line Type: cancer cell line
Origin: Selected for resistance to: ChEBI; CHEBI:72564; Temozolomide (TMZ); Derived from sampling site: Brain; parietal lobe.
Gender: Male
Genomic Alteration: Sequence variation: PTEN p.Glu242Valfs*15 (c.723_724dupTG) (ClinVar=VCV000536553) (from parent cell line); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Sequence variation: TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (from parent cell line)
Caution: Problematic cell line: Misidentified Originally thought (PubMed=19584161) to be a A-172 (CVCL_0131) derivative but shown to be a U-251MG derivative (DOI=10.1158/1078-0432.CCR-13-1821).
Groups: Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00523
Derived From Cell Lines: CVCL_0021 (U-251MG)
Aliases: A172TR3; TR3
Disease(s): autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]
malignant astrocytoma (DOID:3069) [NCI:C60781]

References
Additional References at PubMed
PMID:19584161  


Additional Information

Database Acc Id Source(s)
BioSample SAMN06481106 CELLOSAURUS
Cellosaurus CVCL_1G29 CELLOSAURUS
COSMIC Samples 1236361 CELLOSAURUS
DOI 10.1158/1078-0432.CCR-13-1821 CELLOSAURUS
NCIt C60781 CELLOSAURUS
Orphanet 94 CELLOSAURUS
Wikidata Q54973630 CELLOSAURUS