CVCL_KZ70 - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation) Homo sapiens

Symbol: CVCL_KZ70
Name: PathHunter THP-1 IkappaB Degradation
RGD ID: 21144753
Cell Line Type: cancer cell line
Origin: Population: Japanese; Derived from sampling site: Peripheral blood.
Gender: Male
Characteristics: Characteristics: PathHunter degradation cell lines express a target protein tagged with a beta-galactosidase fragment (Enzyme Donor=ED) Pathway activation results in the degradation of the target protein. The degraded protein is detected by adding to the cell lysis buffer another beta-galactosidase fragment (Enzyme Acceptor=EA). Complementation of the ED and EA enzyme fragments result into a catalytically active enzyme that generate a chemiluminescent signal.
Genomic Alteration: Sequence variation: Gene fusion; CSNK2A1-DDX39B (from parent cell line); Sequence variation: Gene fusion; KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) (from parent cell line); Sequence variation: Heterozygous for NRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000039648) (from parent cell line); Sequence variation: Heterozygous for TP53 p.Arg174fs*3 (c.520_545del26) (from parent cell line); Transfected with: HGNC; 7797; NFKBIA
Related Genes: NFKBIA  
Derived From Cell Lines: CVCL_0006 (THP-1)


Additional Information

Database Acc Id Source(s)
DiscoverX 93-0538C14 CELLOSAURUS
Orphanet 514 CELLOSAURUS
Wikidata Q54938064 CELLOSAURUS