CVCL_1996 - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_1996 (COLO 775) Homo sapiens

Symbol: CVCL_1996
Name: COLO 775
RGD ID: 21138926
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Deep exome analysis
Characteristics: Characteristics: Produces IgG lambda (from parent cell line)
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (ClinVar=VCV000177773) (from parent cell line); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (ClinVar=VCV000045122) (CCLE); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (CCLE); Sequence variation: TRAF3 p.Lys191Leufs*60 (from parent cell line)
Caution: Problematic cell line: Contaminated Shown to be a RPMI-8226 derivative (ECACC). Originally thought to originate from the peripheral blood of a 57 year old female patient with chronic myelogenous leukemia.
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00537
Description: Genome ancestry: African=73.36%; Native American=0%; East Asian, North=2.48%; East Asian, South=0%; South Asian=0%; European, North=7.83%; European, South=16.33% (PubMed=30894373)
Derived From Cell Lines: CVCL_0014 (RPMI-8226)
Aliases: COLO-775
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

References
Additional References at PubMed
PMID:30894373   PMID:31068700  


Additional Information

Database Acc Id Source(s)
BioSample SAMN10988053 CELLOSAURUS
Cell Line Ontology CLO_0002559 CELLOSAURUS
Cellosaurus CVCL_1996 CELLOSAURUS
DepMap ACH-001043 CELLOSAURUS
ECACC 94072236 CELLOSAURUS
NCIt C3242 CELLOSAURUS
Orphanet 29073 CELLOSAURUS
PharmacoDB COLO775_217_2019 CELLOSAURUS
Progenetix CVCL_1996 CELLOSAURUS
Wikidata Q54814146 CELLOSAURUS