CVCL_1862 - Rat Genome Database

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Cell Line : CVCL_1862 (COLO 677) Homo sapiens

Symbol: CVCL_1862
Name: COLO 677
RGD ID: 21138475
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Characteristics: Characteristics: Produces IgG lambda (from parent cell line)
Phenotype: Doubling time: ~40 hours (DSMZ)
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (ClinVar=VCV000177773) (from parent cell line); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (ClinVar=VCV000045122) (from parent cell line); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line); Sequence variation: TRAF3 p.Lys191Leufs*60 (from parent cell line)
Caution: Problematic cell line: Contaminated Shown to be a RPMI-8226 derivative (PubMed=20143388). Originally thought to originate from the lymph nodes of a 50 year-old male patient with a small cell lung carcinoma.
Groups: Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00299
Derived From Cell Lines: CVCL_0014 (RPMI-8226)
Aliases: COLO #677; COLO-677; COLO677; Colorado 677
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

References
Additional References at PubMed
PMID:20143388  


Additional Information

Database Acc Id Source(s)
BioSample SAMN03151910 CELLOSAURUS
Cell Line Ontology CLO_0002550 CELLOSAURUS
Cellosaurus CVCL_1862 CELLOSAURUS
COSMIC Samples 753542 CELLOSAURUS
DSMZ ACC-248 CELLOSAURUS
ECACC 93072109 CELLOSAURUS
GEO GSM784242 CELLOSAURUS
NCIt C3242 CELLOSAURUS
Orphanet 29073 CELLOSAURUS
PharmacoDB COLO677_225_2019 CELLOSAURUS
Progenetix CVCL_1862 CELLOSAURUS
Wikidata Q54814130 CELLOSAURUS