CVCL_JY84 - Rat Genome Database

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Cell Line : CVCL_JY84 (U87MG.DY5) Homo sapiens

Symbol: CVCL_JY84
Name: U87MG.DY5
RGD ID: 21132860
Cell Line Type: cancer cell line
Gender: Male
Genomic Alteration: Sequence variation: Heterozygous for NF1 p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT) (ClinVar=VCV000420078) (from parent cell line); Sequence variation: Homozygous for PTEN c.209+1G>T (ClinVar=VCV000229705); Note=Splice donor mutation (from parent cell line); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Transfected with: HGNC; 3236; EGFR (with p.Val30_Arg297del, p.Tyr1016Phe, p.Tyr1092Phe, p.Tyr1110Phe, p.Tyr1172Phe and p.Tyr1197Phe = EGFRvIII and 5 TyrP site dead).
Caution: Problematic cell line: Misidentified Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Related Genes: EGFR  
Derived From Cell Lines: CVCL_0022 (U-87MG ATCC)
Aliases: U87/DY5
Disease(s): glioblastoma (DOID:3068) [NCI:C3058]

References
Additional References at PubMed
PMID:8810340  


Additional Information

Database Acc Id Source(s)
Cellosaurus CVCL_JY84 CELLOSAURUS
NCIt C3058 CELLOSAURUS
Orphanet 360 CELLOSAURUS
Wikidata Q54973775 CELLOSAURUS