CVCL_B325 - Rat Genome Database

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Cell Line : CVCL_B325 (TK-1 [Human astrocytoma]) Homo sapiens

Symbol: CVCL_B325
Name: TK-1 [Human astrocytoma]
RGD ID: 21121108
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Brain; parietal lobe.
Gender: Male
Availability: Discontinued: JCRB; NIHS0181; true
Genomic Alteration: Sequence variation: PTEN p.Glu242Valfs*15 (c.723_724dupTG) (ClinVar=VCV000536553) (from parent cell line); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Sequence variation: TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (from parent cell line)
Caution: Problematic cell line: Contaminated Shown to be a U-251MG derivative. Originally thought to originate from a 22 year old female patient with a glioblastoma.
Groups: Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00348
Derived From Cell Lines: CVCL_0021 (U-251MG)
Disease(s): autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]
malignant astrocytoma (DOID:3069) [NCI:C60781]

References
Additional References at PubMed
PMID:9183640  


Additional Information

Database Acc Id Source(s)
BioSample SAMN03151978 CELLOSAURUS
Cellosaurus CVCL_B325 CELLOSAURUS
COSMIC Samples 687587 CELLOSAURUS
JCRB JCRB0128 CELLOSAURUS
  NIHS0181 CELLOSAURUS
NCIt C60781 CELLOSAURUS
Orphanet 94 CELLOSAURUS
Wikidata Q54972517 CELLOSAURUS