CVCL_0535 - Rat Genome Database

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Cell Line : CVCL_0535 (SNB-19) Homo sapiens

Symbol: CVCL_0535
Name: SNB-19
RGD ID: 21120301
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Brain; parietal lobe.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: ATCC; CRL-2219; true; Discontinued: JCRB; NIHS0294; true
Phenotype: Doubling time: 34.6 hours (NCI-DTP); ~24 hours (DSMZ)
Genomic Alteration: Sequence variation: Homozygous for PTEN p.Glu242Valfs*15 (c.723_724dupTG) (ClinVar=VCV000536553) (PubMed=17088437); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (from parent cell line); Sequence variation: Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (PubMed=17088437)
Caution: Problematic cell line: Contaminated Shown to be a U-251MG derivative (PubMed=20143388; PubMed=22570425). Originally thought to originate from a 47 year old patient with a left parieto-occipital glioblastoma.
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: NCI-60 cancer cell line panel; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00268
Description: HLA typing: A*02:01:01; B*18; C*05; DPB1*04:02; DQB1*02:01; DRB1*03:01:01 (PubMed=15748285); Genome ancestry: African=0.48%; Native American=0%; East Asian, North=2.88%; East Asian, South=0%; South Asian=0%; European, North=78.25%; European, South=18.39% (PubMed=30894373)
Derived From Cell Lines: CVCL_0021 (U-251MG)
Aliases: SNB.19; SNB19; Surgical Neurology Branch-19
Disease(s): autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]
malignant astrocytoma (DOID:3069) [NCI:C60781]

References
Additional References at PubMed
PMID:2041050   PMID:3121170   PMID:3335022   PMID:8528516   PMID:10700174   PMID:15748285   PMID:17088437   PMID:19372543   PMID:20143388   PMID:20215515   PMID:22068913   PMID:22384151  
PMID:22460905   PMID:22570425   PMID:22628656   PMID:23856246   PMID:23933261   PMID:24279929   PMID:24335698   PMID:24670534   PMID:27377824   PMID:27807467   PMID:30894373   PMID:31068700  
PMID:31978347  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-38 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
ATCC CRL-2219 CELLOSAURUS
BioSample SAMN03151977 CELLOSAURUS
  SAMN03471000 CELLOSAURUS
  SAMN03472567 CELLOSAURUS
BTO BTO_0003761 CELLOSAURUS
Cell Line Ontology CLO_0009093 CELLOSAURUS
Cell Model Passports SIDM00109 CELLOSAURUS
CelloPub CLPUB00261 CELLOSAURUS
Cellosaurus CVCL_0535 CELLOSAURUS
ChEMBL-Cells CHEMBL3307552 CELLOSAURUS
ChEMBL-Targets CHEMBL614164 CELLOSAURUS
COSMIC Samples 1044249 CELLOSAURUS
  1092637 CELLOSAURUS
  1305361 CELLOSAURUS
  1312343 CELLOSAURUS
  1746950 CELLOSAURUS
  1998480 CELLOSAURUS
  2302333 CELLOSAURUS
  2367548 CELLOSAURUS
  2550361 CELLOSAURUS
  875894 CELLOSAURUS
  897439 CELLOSAURUS
  905966 CELLOSAURUS
  974241 CELLOSAURUS
DepMap ACH-001198 CELLOSAURUS
DOI 10.1016/B978-0-12-333530-2.50005-8 CELLOSAURUS
DSMZ ACC-325 CELLOSAURUS
EFO EFO_0002342 CELLOSAURUS
GEO GSM1153396 CELLOSAURUS
  GSM1181304 CELLOSAURUS
  GSM1181321 CELLOSAURUS
  GSM2090 CELLOSAURUS
  GSM2124686 CELLOSAURUS
  GSM326246 CELLOSAURUS
  GSM50178 CELLOSAURUS
  GSM50242 CELLOSAURUS
  GSM743438 CELLOSAURUS
  GSM750785 CELLOSAURUS
  GSM799326 CELLOSAURUS
  GSM799389 CELLOSAURUS
  GSM844697 CELLOSAURUS
  GSM847161 CELLOSAURUS
  GSM887600 CELLOSAURUS
  GSM888683 CELLOSAURUS
IGRhCellID SNB19 CELLOSAURUS
JCRB NIHS0294 CELLOSAURUS
LINCS_LDP LCL-1363 CELLOSAURUS
NCIt C60781 CELLOSAURUS
Orphanet 94 CELLOSAURUS
PharmacoDB SNB19_1429_2019 CELLOSAURUS
PRIDE PXD005942 CELLOSAURUS
Progenetix CVCL_0535 CELLOSAURUS
Wikidata Q54955038 CELLOSAURUS