CVCL_0019 - Rat Genome Database

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Cell Line : CVCL_0019 (SH-SY5Y) Homo sapiens

Symbol: CVCL_0019
Name: SH-SY5Y
RGD ID: 21113481
Cell Line Type: cancer cell line
Origin: Derived from metastatic site: Bone marrow.
Gender: Female
Source: From: Memorial Sloan Kettering Cancer Center; New York; USA
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep tyrosine phosphoproteome analysis; Omics: Deep RNAseq analysis; Omics: GPI-anchored proteins analysis by proteomics; Omics: Mitochondrial proteome analysis by 2D-DE/MS; Omics: N-glycan profiling; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Neuroblastic type (N-type) (PubMed=15720811); Characteristics: There seems to be differences in the retinoic acid (RA)-induced neuronal phenotype of SH-SY5Y cells from ATCC and ECACC After 5 days of RA treatment, ECACC cells are slightly larger in size and contains significant amount of neuroblastic (N-type) cells and a small fraction of epithelial (S-type) cells (PubMed=18957096).
Phenotype: Doubling time: >55 hours (DSMZ)
Genomic Alteration: Sequence variation: ALK p.Phe1174Leu (c.3522C>A) (ClinVar=VCV000217852) (PubMed=28350380)
Caution: Problematic cell line: Partially contaminated Some laboratories that are redistributing this cell line are in fact redistributing a contaminated cell line of mouse origin (PubMed=25182563).
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: ENCODE project common cell types; tier 3; Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 810
Description: Genome ancestry: African=0%; Native American=1.17%; East Asian, North=0.35%; East Asian, South=0.1%; South Asian=0.08%; European, North=69.09%; European, South=29.2% (PubMed=30894373)
Derived From Cell Lines: CVCL_0531 (SK-N-SH)
Child Cell Lines: CVCL_0523 (SH-SY5Y-SPA4CT)
CVCL_5I52 (SH-SY5Y-HFE)
CVCL_5I53 (SH-SY5Y-HFE C282Y)
CVCL_5I54 (SH-SY5Y-HFE H63D)
CVCL_RR53 (SH-SY5YrVCR10)
CVCL_RR81 (SH-SY5YrCDDP200)
CVCL_RS23 (SH-SY5YrCDDP500)
CVCL_RS81 (SH-SY5YrDOX20)
CVCL_RS8O (SH-SY5YrDOX10)
CVCL_U924 (SH-SY5Y Rho0 64/5)
CVCL_UJ94 (SH-SY5Y-TrkA, clone P23A)
CVCL_UJ95 (SH-SY5Y-TrkB, clone BR6)
CVCL_UJ96 (SH-SY5Y-pLNCX2 empty vector)
CVCL_VA24 (SHSY5Y-B7H6)
CVCL_YJ70 (VAMPIRO SH-SY5Y)
CVCL_YJ91 (LINTERNA SH-SY5Y)
CVCL_YK67 (SH-SY5Y TagGFP2-SNCA)
CVCL_ZL49 (SH-SY5Y/VCR)
Aliases: SH-SY5; SH-Sy5y; SH-SY5Y Parental; SHSY-5Y; SHSY5Y; SK-SH-SY5Y; SY5Y
Disease(s): neuroblastoma (DOID:769) [NCI:C3270,ORDO:635]

References
Additional References at PubMed
PMID:1354203   PMID:2535691   PMID:2846152   PMID:3968181   PMID:4748425   PMID:6137586   PMID:10630978   PMID:15150091   PMID:15720811   PMID:16120276   PMID:16822308   PMID:18957096  
PMID:22213050   PMID:22460905   PMID:23421552   PMID:24466371   PMID:25182563   PMID:25730103   PMID:25884760   PMID:26342562   PMID:26972028   PMID:27141528   PMID:28118852   PMID:28350380  
PMID:28601559   PMID:30894373   PMID:31068700  


Additional Information

Database Acc Id Source(s)
ATCC CRL-2266 CELLOSAURUS
BCRJ 0223 CELLOSAURUS
BioSample SAMN10987717 CELLOSAURUS
BTO BTO_0000793 CELLOSAURUS
CCRID 3111C0001CCC000026 CELLOSAURUS
  3131C0001000700097 CELLOSAURUS
  3142C0001000000486 CELLOSAURUS
  3142C0001000000964 CELLOSAURUS
  3153C0001000000223 CELLOSAURUS
Cell Line Ontology CLO_0009015 CELLOSAURUS
Cell Model Passports SIDM01236 CELLOSAURUS
Cellosaurus CVCL_0019 CELLOSAURUS
ChEMBL-Cells CHEMBL3307740 CELLOSAURUS
ChEMBL-Targets CHEMBL614910 CELLOSAURUS
COSMIC Samples 1019933 CELLOSAURUS
  1167410 CELLOSAURUS
  1212536 CELLOSAURUS
  2058109 CELLOSAURUS
  2239470 CELLOSAURUS
  2393641 CELLOSAURUS
  688084 CELLOSAURUS
DepMap ACH-001188 CELLOSAURUS
DSMZ ACC-209 CELLOSAURUS
ECACC 94030304 CELLOSAURUS
EFO EFO_0002717 CELLOSAURUS
ENCODE ENCBS264AAA CELLOSAURUS
GEO GSM1622294 CELLOSAURUS
  GSM231608 CELLOSAURUS
  GSM231609 CELLOSAURUS
  GSM231610 CELLOSAURUS
  GSM231611 CELLOSAURUS
  GSM231612 CELLOSAURUS
  GSM231613 CELLOSAURUS
  GSM231614 CELLOSAURUS
  GSM231615 CELLOSAURUS
  GSM231616 CELLOSAURUS
  GSM231617 CELLOSAURUS
  GSM231618 CELLOSAURUS
  GSM231619 CELLOSAURUS
  GSM231620 CELLOSAURUS
  GSM231621 CELLOSAURUS
  GSM231622 CELLOSAURUS
  GSM231623 CELLOSAURUS
  GSM231624 CELLOSAURUS
  GSM231625 CELLOSAURUS
  GSM231626 CELLOSAURUS
  GSM231627 CELLOSAURUS
  GSM231628 CELLOSAURUS
  GSM231629 CELLOSAURUS
  GSM231630 CELLOSAURUS
  GSM231631 CELLOSAURUS
  GSM231632 CELLOSAURUS
  GSM231633 CELLOSAURUS
  GSM231634 CELLOSAURUS
  GSM231635 CELLOSAURUS
  GSM231636 CELLOSAURUS
  GSM231637 CELLOSAURUS
  GSM231638 CELLOSAURUS
  GSM231639 CELLOSAURUS
  GSM231640 CELLOSAURUS
  GSM231641 CELLOSAURUS
  GSM231642 CELLOSAURUS
  GSM231643 CELLOSAURUS
  GSM231644 CELLOSAURUS
  GSM231645 CELLOSAURUS
  GSM231646 CELLOSAURUS
  GSM231647 CELLOSAURUS
  GSM231648 CELLOSAURUS
  GSM231649 CELLOSAURUS
  GSM231650 CELLOSAURUS
  GSM231651 CELLOSAURUS
  GSM231652 CELLOSAURUS
  GSM231653 CELLOSAURUS
  GSM231654 CELLOSAURUS
  GSM231655 CELLOSAURUS
  GSM231656 CELLOSAURUS
  GSM231657 CELLOSAURUS
  GSM231658 CELLOSAURUS
  GSM231659 CELLOSAURUS
  GSM231660 CELLOSAURUS
  GSM231661 CELLOSAURUS
  GSM231662 CELLOSAURUS
  GSM231663 CELLOSAURUS
  GSM231664 CELLOSAURUS
  GSM231665 CELLOSAURUS
  GSM231666 CELLOSAURUS
  GSM231667 CELLOSAURUS
  GSM231668 CELLOSAURUS
  GSM231669 CELLOSAURUS
  GSM231670 CELLOSAURUS
  GSM231671 CELLOSAURUS
  GSM231672 CELLOSAURUS
  GSM231673 CELLOSAURUS
  GSM2371253 CELLOSAURUS
  GSM2394368 CELLOSAURUS
  GSM692874 CELLOSAURUS
  GSM887570 CELLOSAURUS
  GSM888653 CELLOSAURUS
ICLC HTL95013 CELLOSAURUS
KCLB 22266 CELLOSAURUS
LINCS_LDP LCL-2000 CELLOSAURUS
Lonza 132 CELLOSAURUS
MetaboLights MTBLS455 CELLOSAURUS
NCIt C3270 CELLOSAURUS
Orphanet 635 CELLOSAURUS
PharmacoDB SHSY5Y_1374_2019 CELLOSAURUS
PRIDE PXD003105 CELLOSAURUS
  PXD003914 CELLOSAURUS
  PXD004452 CELLOSAURUS
  PXD010005 CELLOSAURUS
  PXD010027 CELLOSAURUS
Progenetix CVCL_0019 CELLOSAURUS
Wikidata Q7390126 CELLOSAURUS