CVCL_0014 - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_0014 (RPMI-8226) Homo sapiens

Symbol: CVCL_0014
Name: RPMI-8226
RGD ID: 21113478
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Produces IgG lambda
Phenotype: Doubling time: 60 hours (PubMed=25984343); 33.5 hours (NCI-DTP); ~60-70 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (ClinVar=VCV000177773) (PubMed=17088437); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (ClinVar=VCV000045122) (PubMed=11157491; PubMed=12068308; PubMed=17088437; PubMed=21173094); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133); Note=Temperature-sensitive (PubMed=17088437; PubMed=18277095; PubMed=21173094); Sequence variation: TRAF3 p.Lys191Leufs*60 (PubMed=17692805)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel; Part of: NCI-7 clinical proteomics reference material cell line panel
Description: HLA typing: A*30:01,68:02; B*15:03,15:10; C*02:02:04,03:04:02; DPB1*01:01:02,13:01; DQB1*02:01,02:02; DRB1*03:01:01,07:01 (PubMed=15748285); HLA typing: A*30,68:02; B*15,15; C*02:02,03:04 (Direct_author_submission); Genome ancestry: African=73.94%; Native American=0%; East Asian, North=1.06%; East Asian, South=0%; South Asian=0%; European, North=11.76%; European, South=13.24% (PubMed=30894373)
Notes: Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck C
Child Cell Lines: CVCL_1862 (COLO 677)
CVCL_1996 (COLO 775)
CVCL_3732 (KR-12)
CVCL_4V90 (RPMI-8226/MR4)
CVCL_9V32 (B6B11)
CVCL_J431 (RPMI-8226/Dox40)
CVCL_J432 (RPMI-8226/Dox6)
CVCL_J434 (RPMI-8226/LR-5)
CVCL_XK17 (RPMI-8226-R)
Aliases: 8226; 8226/S; GM 2132; GM02132; GM02132C; GM2132; Roswell Park Memorial Institute 8226; RPMI #8226; RPMI 8226; RPMI 8226/S; RPMI no 8226; RPMI no. 8226; RPMI-8226S; RPMI-8266; RPMI-8826; RPMI.8226; RPMI8226; RPMI8226/S; Simpson
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

References
Additional References at PubMed
PMID:1720489   PMID:2041050   PMID:2140233   PMID:2537114   PMID:3893568   PMID:4177524   PMID:4366935   PMID:5243066   PMID:6042436   PMID:8943038   PMID:9290701   PMID:9510473  
PMID:10087940   PMID:10557056   PMID:10583232   PMID:10700174   PMID:10936422   PMID:11154231   PMID:11157491   PMID:12068308   PMID:14555701   PMID:15215163   PMID:15748285   PMID:16956823  
PMID:17088437   PMID:17171682   PMID:17692805   PMID:18277095   PMID:18605421   PMID:18647998   PMID:18700954   PMID:19306352   PMID:19372543   PMID:20164919   PMID:20215515   PMID:21173094  
PMID:22068913   PMID:22384151   PMID:22460905   PMID:22628656   PMID:23074853   PMID:23856246   PMID:23933261   PMID:24279929   PMID:24670534   PMID:25485619   PMID:25688540   PMID:25984343  
PMID:27377824   PMID:27397505   PMID:27807467   PMID:28196595   PMID:29718670   PMID:30285677   PMID:30894373   PMID:31068700   PMID:31160637   PMID:31465861   PMID:31978347  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
  E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-38 CELLOSAURUS
  E-MTAB-7721 CELLOSAURUS
  E-MTAB-7722 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
  E-TABM-937 CELLOSAURUS
ATCC CCL-155 CELLOSAURUS
  CRM-CCL-155 CELLOSAURUS
BCRC 60384 CELLOSAURUS
BioSample SAMN03471458 CELLOSAURUS
  SAMN03472934 CELLOSAURUS
  SAMN03473581 CELLOSAURUS
  SAMN10988318 CELLOSAURUS
BTO BTO_0000726 CELLOSAURUS
CCRID 3111C0001CCC000083 CELLOSAURUS
Cell Line Ontology CLO_0008873 CELLOSAURUS
  CLO_0031845 CELLOSAURUS
Cell Model Passports SIDM00087 CELLOSAURUS
CelloPub CLPUB00447 CELLOSAURUS
Cellosaurus CVCL_0014 CELLOSAURUS
ChEMBL-Cells CHEMBL3307732 CELLOSAURUS
ChEMBL-Targets CHEMBL614882 CELLOSAURUS
Coriell GM02132 CELLOSAURUS
COSMIC Samples 1044255 CELLOSAURUS
  1092628 CELLOSAURUS
  1139509 CELLOSAURUS
  1139639 CELLOSAURUS
  1175858 CELLOSAURUS
  1305340 CELLOSAURUS
  1312326 CELLOSAURUS
  1762461 CELLOSAURUS
  1998470 CELLOSAURUS
  2081405 CELLOSAURUS
  2159574 CELLOSAURUS
  2367260 CELLOSAURUS
  2391801 CELLOSAURUS
  720773 CELLOSAURUS
  724856 CELLOSAURUS
  742952 CELLOSAURUS
  759915 CELLOSAURUS
  760397 CELLOSAURUS
  875867 CELLOSAURUS
  886084 CELLOSAURUS
  888018 CELLOSAURUS
  897452 CELLOSAURUS
  905964 CELLOSAURUS
  919145 CELLOSAURUS
  974250 CELLOSAURUS
  991554 CELLOSAURUS
  999791 CELLOSAURUS
Cosmic-CLP 905964 CELLOSAURUS
DepMap ACH-000817 CELLOSAURUS
DOI 10.1007/978-1-4757-1647-4_11 CELLOSAURUS
  10.1016/B978-0-12-221970-2.50457-5 CELLOSAURUS
  10.1016/B978-0-12-427150-0.50135-2 CELLOSAURUS
DSMZ ACC-402 CELLOSAURUS
ECACC 87012702 CELLOSAURUS
EFO EFO_0002322 CELLOSAURUS
ENCODE ENCBS457ZNO CELLOSAURUS
  ENCBS604KZU CELLOSAURUS
GDSC 905964 CELLOSAURUS
GEO GSM1153419 CELLOSAURUS
  GSM1181289 CELLOSAURUS
  GSM1181334 CELLOSAURUS
  GSM1199922 CELLOSAURUS
  GSM1199923 CELLOSAURUS
  GSM1199924 CELLOSAURUS
  GSM1199925 CELLOSAURUS
  GSM1199926 CELLOSAURUS
  GSM1199927 CELLOSAURUS
  GSM1374855 CELLOSAURUS
  GSM143340 CELLOSAURUS
  GSM1666389 CELLOSAURUS
  GSM1670389 CELLOSAURUS
  GSM2124680 CELLOSAURUS
  GSM2135 CELLOSAURUS
  GSM290304 CELLOSAURUS
  GSM50198 CELLOSAURUS
  GSM50261 CELLOSAURUS
  GSM562819 CELLOSAURUS
  GSM621590 CELLOSAURUS
  GSM743461 CELLOSAURUS
  GSM750813 CELLOSAURUS
  GSM799349 CELLOSAURUS
  GSM799412 CELLOSAURUS
  GSM887548 CELLOSAURUS
  GSM888631 CELLOSAURUS
IGRhCellID RPMI8226 CELLOSAURUS
JCRB IFO50013 CELLOSAURUS
  JCRB0034 CELLOSAURUS
KCLB 10155 CELLOSAURUS
LiGeA CCLE_817 CELLOSAURUS
LINCS_LDP LCL-2049 CELLOSAURUS
Lonza 61 CELLOSAURUS
NCIt C3242 CELLOSAURUS
Orphanet 29073 CELLOSAURUS
PharmacoDB RPMI8226_1327_2019 CELLOSAURUS
PRIDE PXD001276 CELLOSAURUS
  PXD005942 CELLOSAURUS
  PXD013859 CELLOSAURUS
Progenetix CVCL_0014 CELLOSAURUS
RCB RCB3010 CELLOSAURUS
Wikidata Q54951245 CELLOSAURUS