CVCL_0013 - Rat Genome Database

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Cell Line : CVCL_0013 (MOLT-4) Homo sapiens

Symbol: CVCL_0013
Name: MOLT-4
RGD ID: 21113475
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Phenotype: Doubling time: 31.56 +- 1.49 hours (PubMed=24762992); 33 hours (PubMed=17117183); 29 hours (PubMed=20922763); 27.9 hours (NCI-DTP); ~40 hours (DSMZ); 24-48 hours (CLS); Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger)
Genomic Alteration: Sequence variation: Heterozygous for NOTCH1 p.Leu1600Pro (c.4799T>C) (PubMed=15472075); Sequence variation: Heterozygous for NOTCH1 p.Pro2514Argfs*4 (c.7541_7542delCT) (ClinVar=VCV000581973) (PubMed=15472075); Sequence variation: Heterozygous for NRAS p.Gly12Cys (c.34G>T) (ClinVar=VCV000040468) (PubMed=1206830; PubMed=17088437); Sequence variation: Homozygous for PTEN p.Lys267Argfs*9 (c.800delA) (p.Leu265fs; c.795delA) (ClinVar=VCV000092828) (PubMed=17088437); Sequence variation: Heterozygous for STK11 p.Gln214Ter (c.640C>T) (ClinVar=VCV000428759) (PubMed=17088437); Sequence variation: Heterozygous for TP53 p.Arg306Ter (c.916C>T) (ClinVar=VCV000142144) (PubMed=17088437)
Groups: Part of: 12th International Histocompatibility Workshop (12IHW) cell line panel; Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel; Part of: NCI-60 cancer cell line panel
Description: HLA typing: A*01:01:01,25:01; B*18,57:01:01; C*06:02,12:03:01; DPB1*02:01:02; DQB1*02:02,03:01:01; DRB1*07,12 (PubMed=15748285); HLA typing: A*01:01:01:01,25:01; B*57:01:01,18:01; C*06:02,12:03; DPA1*01:03; DPB1*02:01:02; DRB1*07,12:01 (IPD-IMGT/HLA; 11094); Genome ancestry: African=0.38%; Native American=0%; East Asian, North=1.74%; East Asian, South=0%; South Asian=0.94%; European, North=68.08%; European, South=28.87% (PubMed=30894373)
Child Cell Lines: CVCL_2657 (NH17)
CVCL_2792 (MOLT-4F)
CVCL_4Y72 (MOLT-4/ADR)
CVCL_5J16 (MOLT-4-luc2)
CVCL_A1BB (MOLT4/P)
CVCL_F827 (MOLT-4 clone 8)
CVCL_F830 (MOLT-4V)
CVCL_M771 (M311)
Originate from same individual as: CVCL_0624 (MOLT-3)
Aliases: GM02219; GM02219C; GM02219D; GM2219C; MOLT 4; Molt-4; MOLT.4; MOLT4
Disease(s): T-cell adult acute lymphocytic leukemia (DOID:5602) [NCI:C9142]

References
Additional References at PubMed
PMID:165156   PMID:1765142   PMID:2041050   PMID:2140233   PMID:2144611   PMID:2846092   PMID:3335022   PMID:4547172   PMID:4567231   PMID:6181032   PMID:6198871   PMID:6200433  
PMID:6582512   PMID:6954533   PMID:8127147   PMID:8316623   PMID:8547074   PMID:8558913   PMID:8641406   PMID:9510473   PMID:9685479   PMID:9787181   PMID:10071127   PMID:10700174  
PMID:11021758   PMID:11986953   PMID:12068308   PMID:15472075   PMID:15748285   PMID:15901131   PMID:16408098   PMID:17088437   PMID:17117183   PMID:19372543   PMID:20164919   PMID:20215515  
PMID:20922763   PMID:22068913   PMID:22384151   PMID:22460905   PMID:22628656   PMID:23856246   PMID:23933261   PMID:24279929   PMID:24670534   PMID:24762992   PMID:26295583   PMID:27377824  
PMID:27397505   PMID:27807467   PMID:28196595   PMID:30894373   PMID:31068700   PMID:31160637   PMID:32449352  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-3610 CELLOSAURUS
  E-MTAB-38 CELLOSAURUS
  E-MTAB-7721 CELLOSAURUS
  E-MTAB-7722 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
ATCC CRL-1582 CELLOSAURUS
BCRC 60060 CELLOSAURUS
BCRJ 0176 CELLOSAURUS
BioSample SAMN03470847 CELLOSAURUS
  SAMN03471400 CELLOSAURUS
  SAMN03472410 CELLOSAURUS
  SAMN03473319 CELLOSAURUS
  SAMN10988202 CELLOSAURUS
BTO BTO_0000873 CELLOSAURUS
CCRID 3111C0001CCC000043 CELLOSAURUS
  3131C0001000700037 CELLOSAURUS
  3131C0001000700226 CELLOSAURUS
  3131C0001001200018 CELLOSAURUS
  3142C0001000000079 CELLOSAURUS
Cell Line Ontology CLO_0007825 CELLOSAURUS
  CLO_0032246 CELLOSAURUS
  CLO_0050992 CELLOSAURUS
Cell Model Passports SIDM00145 CELLOSAURUS
CelloPub CLPUB00447 CELLOSAURUS
Cellosaurus CVCL_0013 CELLOSAURUS
ChEMBL-Cells CHEMBL3307557 CELLOSAURUS
ChEMBL-Targets CHEMBL614177 CELLOSAURUS
Coriell GM02219 CELLOSAURUS
COSMIC Samples 1012099 CELLOSAURUS
  1019314 CELLOSAURUS
  1044254 CELLOSAURUS
  1070704 CELLOSAURUS
  1071877 CELLOSAURUS
  1082518 CELLOSAURUS
  1092615 CELLOSAURUS
  1115596 CELLOSAURUS
  1118467 CELLOSAURUS
  1127263 CELLOSAURUS
  1130237 CELLOSAURUS
  1151788 CELLOSAURUS
  1175131 CELLOSAURUS
  1175857 CELLOSAURUS
  1176596 CELLOSAURUS
  1226858 CELLOSAURUS
  1305339 CELLOSAURUS
  1312325 CELLOSAURUS
  1330500 CELLOSAURUS
  1483362 CELLOSAURUS
  1509200 CELLOSAURUS
  1524808 CELLOSAURUS
  1639636 CELLOSAURUS
  1664513 CELLOSAURUS
  1811158 CELLOSAURUS
  1998457 CELLOSAURUS
  2039521 CELLOSAURUS
  2165720 CELLOSAURUS
  2361368 CELLOSAURUS
  2560251 CELLOSAURUS
  2602924 CELLOSAURUS
  716176 CELLOSAURUS
  721716 CELLOSAURUS
  801730 CELLOSAURUS
  850194 CELLOSAURUS
  850381 CELLOSAURUS
  875865 CELLOSAURUS
  897451 CELLOSAURUS
  905958 CELLOSAURUS
  913409 CELLOSAURUS
  919154 CELLOSAURUS
  922677 CELLOSAURUS
  932766 CELLOSAURUS
  933547 CELLOSAURUS
  974249 CELLOSAURUS
  991545 CELLOSAURUS
  999763 CELLOSAURUS
Cosmic-CLP 905958 CELLOSAURUS
DepMap ACH-001127 CELLOSAURUS
DOI 10.1016/B978-0-12-221970-2.50457-5 CELLOSAURUS
  10.11418/jtca1981.15.4_211 CELLOSAURUS
  10.4172/2157-7145.S2-005 CELLOSAURUS
DSMZ ACC-362 CELLOSAURUS
ECACC 85011413 CELLOSAURUS
  94022544 CELLOSAURUS
EFO EFO_0001220 CELLOSAURUS
GDSC 905958 CELLOSAURUS
GEO GSM1178423 CELLOSAURUS
  GSM1178424 CELLOSAURUS
  GSM1178425 CELLOSAURUS
  GSM1181333 CELLOSAURUS
  GSM1181349 CELLOSAURUS
  GSM1670128 CELLOSAURUS
  GSM1696583 CELLOSAURUS
  GSM1696584 CELLOSAURUS
  GSM1696585 CELLOSAURUS
  GSM1696586 CELLOSAURUS
  GSM2092 CELLOSAURUS
  GSM2124644 CELLOSAURUS
  GSM236794 CELLOSAURUS
  GSM236830 CELLOSAURUS
  GSM4471876 CELLOSAURUS
  GSM50196 CELLOSAURUS
  GSM50912 CELLOSAURUS
  GSM743460 CELLOSAURUS
  GSM750821 CELLOSAURUS
  GSM799348 CELLOSAURUS
  GSM799411 CELLOSAURUS
  GSM887336 CELLOSAURUS
  GSM888412 CELLOSAURUS
ICLC HTL99025 CELLOSAURUS
IGRhCellID MOLT4 CELLOSAURUS
IHW IHW09226 CELLOSAURUS
IPD-IMGT/HLA 11094 CELLOSAURUS
JCRB IFO50362 CELLOSAURUS
  JCRB9031 CELLOSAURUS
KCLB 21582 CELLOSAURUS
LINCS_LDP LCL-1019 CELLOSAURUS
Lonza 810 CELLOSAURUS
NCIt C9142 CELLOSAURUS
Orphanet 99861 CELLOSAURUS
PharmacoDB MOLT4_958_2019 CELLOSAURUS
PRIDE PXD005942 CELLOSAURUS
  PXD018565 CELLOSAURUS
Progenetix CVCL_0013 CELLOSAURUS
RCB RCB0206 CELLOSAURUS
Wikidata Q54906365 CELLOSAURUS