CVCL_0007 - Rat Genome Database

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Cell Line : CVCL_0007 (U-937) Homo sapiens

Symbol: CVCL_0007
Name: U-937
RGD ID: 21113451
Cell Line Type: cancer cell line
Origin: Karyotypic information: Has lost chromosome Y; Derived from sampling site: Pleural effusion.
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Proteome analysis by 2D-DE/MS; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: ATCC; CRL-1593; true; Discontinued: RCB; RCB1978; true; Discontinued: TKG; TKG 0279; probable
Characteristics: Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA)
Phenotype: Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ)
Genomic Alteration: Sequence variation: Gene fusion; PICALM-MLLT10 (CALM-AF10) (PubMed=8643484; PubMed=25485619); Sequence variation: Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (PubMed=10966170; CCLE); Sequence variation: Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59) (ClinVar=VCV000428908); Note=Splice donor mutation (PubMed=1571549; CCLE)
Caution: Problematic cell line: Partially contaminated Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937.
Groups: Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: LL-100 blood cancer cell line panel; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168
Description: HLA typing: DRB1*16:01 (IPD-IMGT/HLA; 11507); Genome ancestry: African=0%; Native American=0%; East Asian, North=2.39%; East Asian, South=0%; South Asian=0%; European, North=71.54%; European, South=26.06% (PubMed=30894373)
Notes: Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007)
Child Cell Lines: CVCL_1775 (TUR)
CVCL_2082 (JOSK-I)
CVCL_2083 (JOSK-M)
CVCL_2810 (U-937 cl1-14)
CVCL_2811 (U-937 cl1-22)
CVCL_2Z95 (U937-DC-SIGN)
CVCL_3680 (EL 1)
CVCL_4V23 (U937/ara-C)
CVCL_6444 (SC)
CVCL_8141 (JOSK-K)
CVCL_8142 (JOSK-S)
CVCL_8442 (MOBS-1)
CVCL_8466 (YAA)
CVCL_8467 (YAP)
CVCL_8765 (U-937 DE-4)
CVCL_8927 (U937(CD59+))
CVCL_8932 (U937(CD59-))
CVCL_9997 (SAML-1)
CVCL_L107 (PH [Human])
CVCL_M769 (U1/HIV-1)
CVCL_M770 (U38)
CVCL_U631 (U-937 GTB)
CVCL_VG84 (U-M)
CVCL_WV55 (U-937/CR)
CVCL_WV56 (U-937 RERC)
CVCL_X000 (U-937-AG)
CVCL_X608 (U937/HIV-2MS)
CVCL_Y170 (U937/clone21)
CVCL_Y171 (U937/clone36)
CVCL_Y172 (U937/clone41)
CVCL_Y173 (U937/clone49)
CVCL_Y174 (U937/UK110)
CVCL_Y175 (U937/UK711)
Aliases: U 937; U937
Disease(s): adult acute monocytic leukemia (DOID:0080149) [NCI:C8263]

References
Additional References at PubMed
PMID:178611   PMID:1083890   PMID:1571549   PMID:1913629   PMID:2140233   PMID:6091813   PMID:6582512   PMID:7759961   PMID:8300570   PMID:8547074   PMID:8558913   PMID:8558920  
PMID:8643484   PMID:9371509   PMID:9510473   PMID:9685479   PMID:9738977   PMID:10352142   PMID:10676951   PMID:10966170   PMID:11701946   PMID:12393283   PMID:15637111   PMID:15843827  
PMID:16408098   PMID:20801507   PMID:21269460   PMID:22460905   PMID:25485619   PMID:30285677   PMID:30894373   PMID:31068700   PMID:31160637   PMID:31978347  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
  E-MTAB-2770 CELLOSAURUS
  E-MTAB-7721 CELLOSAURUS
  E-MTAB-7722 CELLOSAURUS
ATCC CRL-1593 CELLOSAURUS
  CRL-1593.2 CELLOSAURUS
BCRC 60435 CELLOSAURUS
BCRJ 0242 CELLOSAURUS
BioSample SAMN03472409 CELLOSAURUS
  SAMN03473173 CELLOSAURUS
  SAMN03473567 CELLOSAURUS
  SAMN10988180 CELLOSAURUS
BTO BTO_0001412 CELLOSAURUS
CCRID 3111C0001CCC000059 CELLOSAURUS
  3131C0001000700059 CELLOSAURUS
  3131C0001000700159 CELLOSAURUS
  3142C0001000000078 CELLOSAURUS
Cell Line Ontology CLO_0009450 CELLOSAURUS
  CLO_0009465 CELLOSAURUS
Cell Model Passports SIDM01195 CELLOSAURUS
Cellosaurus CVCL_0007 CELLOSAURUS
ChEMBL-Cells CHEMBL3308006 CELLOSAURUS
ChEMBL-Targets CHEMBL612794 CELLOSAURUS
COSMIC Samples 1012127 CELLOSAURUS
  1019837 CELLOSAURUS
  1067446 CELLOSAURUS
  1070690 CELLOSAURUS
  1078726 CELLOSAURUS
  1082516 CELLOSAURUS
  1086353 CELLOSAURUS
  1089523 CELLOSAURUS
  1107178 CELLOSAURUS
  1127260 CELLOSAURUS
  1150904 CELLOSAURUS
  1176581 CELLOSAURUS
  1181605 CELLOSAURUS
  1191692 CELLOSAURUS
  1465967 CELLOSAURUS
  1523828 CELLOSAURUS
  1524826 CELLOSAURUS
  1582388 CELLOSAURUS
  1601066 CELLOSAURUS
  1604865 CELLOSAURUS
  1995661 CELLOSAURUS
  2301570 CELLOSAURUS
  2361376 CELLOSAURUS
  2750876 CELLOSAURUS
  787483 CELLOSAURUS
  798666 CELLOSAURUS
  821044 CELLOSAURUS
  850382 CELLOSAURUS
  852000 CELLOSAURUS
  919123 CELLOSAURUS
  922162 CELLOSAURUS
  932770 CELLOSAURUS
  947364 CELLOSAURUS
  975307 CELLOSAURUS
  991558 CELLOSAURUS
  994178 CELLOSAURUS
  999781 CELLOSAURUS
DepMap ACH-000406 CELLOSAURUS
DOI 10.1007/978-1-4757-1647-4_13 CELLOSAURUS
  10.1007/978-94-011-3550-4_20 CELLOSAURUS
  10.1016/j.actaastro.2013.06.007 CELLOSAURUS
  10.1159/000415060 CELLOSAURUS
  10.21203/rs.3.rs-94743/v1 CELLOSAURUS
DSMZ ACC-5 CELLOSAURUS
ECACC 85011440 CELLOSAURUS
EFO EFO_0001257 CELLOSAURUS
GEO GSE66854 CELLOSAURUS
  GSM1028244 CELLOSAURUS
  GSM1028245 CELLOSAURUS
  GSM1374975 CELLOSAURUS
  GSM1670560 CELLOSAURUS
  GSM2020 CELLOSAURUS
  GSM236809 CELLOSAURUS
  GSM236845 CELLOSAURUS
  GSM482491 CELLOSAURUS
  GSM743413 CELLOSAURUS
  GSM887724 CELLOSAURUS
  GSM888818 CELLOSAURUS
ICLC HTL94002 CELLOSAURUS
IPD-IMGT/HLA 11507 CELLOSAURUS
JCRB IFO50038 CELLOSAURUS
  JCRB9021 CELLOSAURUS
KCLB 21593.1 CELLOSAURUS
LiGeA CCLE_826 CELLOSAURUS
LINCS_HMS 50869 CELLOSAURUS
LINCS_LDP LCL-1125 CELLOSAURUS
Lonza 135 CELLOSAURUS
MESH D020298 CELLOSAURUS
NCIt C8263 CELLOSAURUS
Orphanet 514 CELLOSAURUS
PharmacoDB U937_1624_2019 CELLOSAURUS
PRIDE PXD001521 CELLOSAURUS
  PXD001522 CELLOSAURUS
  PXD001523 CELLOSAURUS
Progenetix CVCL_0007 CELLOSAURUS
RCB RCB1978 CELLOSAURUS
Wikidata Q7863610 CELLOSAURUS