Cell Line : CVCL_0007 (U-937) Homo sapiens
Symbol:	CVCL_0007
Name:	U-937
RGD ID:	21113451
Cell Line Type:	cancer cell line
Origin:	Karyotypic information: Has lost chromosome Y; Derived from sampling site: Pleural effusion.
Gender:	Male
Research Use:	Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Proteome analysis by 2D-DE/MS; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability:	Discontinued: ATCC; CRL-1593; true; Discontinued: RCB; RCB1978; true; Discontinued: TKG; TKG 0279; probable
Characteristics:	Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA)
Phenotype:	Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ)
Genomic Alteration:	Sequence variation: Gene fusion; PICALM-MLLT10 (CALM-AF10) (PubMed=8643484; PubMed=25485619); Sequence variation: Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (PubMed=10966170; CCLE); Sequence variation: Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59) (ClinVar=VCV000428908); Note=Splice donor mutation (PubMed=1571549; CCLE)
Caution:	Problematic cell line: Partially contaminated Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937.
Groups:	Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: LL-100 blood cancer cell line panel; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168
Description:	HLA typing: DRB1*16:01 (IPD-IMGT/HLA; 11507); Genome ancestry: African=0%; Native American=0%; East Asian, North=2.39%; East Asian, South=0%; South Asian=0%; European, North=71.54%; European, South=26.06% (PubMed=30894373)
Notes:	Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007)
Child Cell Lines:	CVCL_1775 (TUR) CVCL_2082 (JOSK-I) CVCL_2083 (JOSK-M) CVCL_2810 (U-937 cl1-14) CVCL_2811 (U-937 cl1-22) CVCL_2Z95 (U937-DC-SIGN) CVCL_3680 (EL 1) CVCL_4V23 (U937/ara-C) CVCL_6444 (SC) CVCL_8141 (JOSK-K) CVCL_8142 (JOSK-S) CVCL_8442 (MOBS-1) CVCL_8466 (YAA) CVCL_8467 (YAP) CVCL_8765 (U-937 DE-4) CVCL_8927 (U937(CD59+)) CVCL_8932 (U937(CD59-)) CVCL_9997 (SAML-1) CVCL_L107 (PH [Human]) CVCL_M769 (U1/HIV-1) CVCL_M770 (U38) CVCL_U631 (U-937 GTB) CVCL_VG84 (U-M) CVCL_WV55 (U-937/CR) CVCL_WV56 (U-937 RERC) CVCL_X000 (U-937-AG) CVCL_X608 (U937/HIV-2MS) CVCL_Y170 (U937/clone21) CVCL_Y171 (U937/clone36) CVCL_Y172 (U937/clone41) CVCL_Y173 (U937/clone49) CVCL_Y174 (U937/UK110) CVCL_Y175 (U937/UK711)
Aliases:	U 937; U937
Disease(s):	adult acute monocytic leukemia (DOID:0080149) [NCI:C8263]

Additional References at PubMed

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PMID:178611	PMID:1083890	PMID:1571549	PMID:1913629	PMID:2140233	PMID:6091813	PMID:6582512	PMID:7759961	PMID:8300570	PMID:8547074	PMID:8558913	PMID:8558920
PMID:8643484	PMID:9371509	PMID:9510473	PMID:9685479	PMID:9738977	PMID:10352142	PMID:10676951	PMID:10966170	PMID:11701946	PMID:12393283	PMID:15637111	PMID:15843827
PMID:16408098	PMID:20801507	PMID:21269460	PMID:22460905	PMID:25485619	PMID:30285677	PMID:30894373	PMID:31068700	PMID:31160637	PMID:31978347

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External Database Links

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Database	Acc Id	Source(s)
ArrayExpress	E-MTAB-2706	CELLOSAURUS
	E-MTAB-2770	CELLOSAURUS
	E-MTAB-7721	CELLOSAURUS
	E-MTAB-7722	CELLOSAURUS
ATCC	CRL-1593	CELLOSAURUS
	CRL-1593.2	CELLOSAURUS
BCRC	60435	CELLOSAURUS
BCRJ	0242	CELLOSAURUS
BioSample	SAMN03472409	CELLOSAURUS
	SAMN03473173	CELLOSAURUS
	SAMN03473567	CELLOSAURUS
	SAMN10988180	CELLOSAURUS
BTO	BTO_0001412	CELLOSAURUS
CCRID	3111C0001CCC000059	CELLOSAURUS
	3131C0001000700059	CELLOSAURUS
	3131C0001000700159	CELLOSAURUS
	3142C0001000000078	CELLOSAURUS
Cell Line Ontology	CLO_0009450	CELLOSAURUS
	CLO_0009465	CELLOSAURUS
Cell Model Passports	SIDM01195	CELLOSAURUS
Cellosaurus	CVCL_0007	CELLOSAURUS
ChEMBL-Cells	CHEMBL3308006	CELLOSAURUS
ChEMBL-Targets	CHEMBL612794	CELLOSAURUS
COSMIC Samples	1012127	CELLOSAURUS
	1019837	CELLOSAURUS
	1067446	CELLOSAURUS
	1070690	CELLOSAURUS
	1078726	CELLOSAURUS
	1082516	CELLOSAURUS
	1086353	CELLOSAURUS
	1089523	CELLOSAURUS
	1107178	CELLOSAURUS
	1127260	CELLOSAURUS
	1150904	CELLOSAURUS
	1176581	CELLOSAURUS
	1181605	CELLOSAURUS
	1191692	CELLOSAURUS
	1465967	CELLOSAURUS
	1523828	CELLOSAURUS
	1524826	CELLOSAURUS
	1582388	CELLOSAURUS
	1601066	CELLOSAURUS
	1604865	CELLOSAURUS
	1995661	CELLOSAURUS
	2301570	CELLOSAURUS
	2361376	CELLOSAURUS
	2750876	CELLOSAURUS
	787483	CELLOSAURUS
	798666	CELLOSAURUS
	821044	CELLOSAURUS
	850382	CELLOSAURUS
	852000	CELLOSAURUS
	919123	CELLOSAURUS
	922162	CELLOSAURUS
	932770	CELLOSAURUS
	947364	CELLOSAURUS
	975307	CELLOSAURUS
	991558	CELLOSAURUS
	994178	CELLOSAURUS
	999781	CELLOSAURUS
DepMap	ACH-000406	CELLOSAURUS
DOI	10.1007/978-1-4757-1647-4_13	CELLOSAURUS
	10.1007/978-94-011-3550-4_20	CELLOSAURUS
	10.1016/j.actaastro.2013.06.007	CELLOSAURUS
	10.1159/000415060	CELLOSAURUS
	10.21203/rs.3.rs-94743/v1	CELLOSAURUS
DSMZ	ACC-5	CELLOSAURUS
ECACC	85011440	CELLOSAURUS
EFO	EFO_0001257	CELLOSAURUS
GEO	GSE66854	CELLOSAURUS
	GSM1028244	CELLOSAURUS
	GSM1028245	CELLOSAURUS
	GSM1374975	CELLOSAURUS
	GSM1670560	CELLOSAURUS
	GSM2020	CELLOSAURUS
	GSM236809	CELLOSAURUS
	GSM236845	CELLOSAURUS
	GSM482491	CELLOSAURUS
	GSM743413	CELLOSAURUS
	GSM887724	CELLOSAURUS
	GSM888818	CELLOSAURUS
ICLC	HTL94002	CELLOSAURUS
IPD-IMGT/HLA	11507	CELLOSAURUS
JCRB	IFO50038	CELLOSAURUS
	JCRB9021	CELLOSAURUS
KCLB	21593.1	CELLOSAURUS
LiGeA	CCLE_826	CELLOSAURUS
LINCS_HMS	50869	CELLOSAURUS
LINCS_LDP	LCL-1125	CELLOSAURUS
Lonza	135	CELLOSAURUS
MESH	D020298	CELLOSAURUS
NCIt	C8263	CELLOSAURUS
Orphanet	514	CELLOSAURUS
PharmacoDB	U937_1624_2019	CELLOSAURUS
PRIDE	PXD001521	CELLOSAURUS
	PXD001522	CELLOSAURUS
	PXD001523	CELLOSAURUS
Progenetix	CVCL_0007	CELLOSAURUS
RCB	RCB1978	CELLOSAURUS
Wikidata	Q7863610	CELLOSAURUS

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