CVCL_0005 - Rat Genome Database

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Cell Line : CVCL_0005 (NB4) Homo sapiens

Symbol: CVCL_0005
Name: NB4
RGD ID: 21113449
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Bone marrow.
Gender: Female
Research Use: Omics: Cell surface proteome; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Phenotype: Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Gene fusion; PML-RARA (PubMed=12353268; PubMed=15843827); Sequence variation: Heterozygous for KRAS p.Ala18Asp (c.53C>A) (CCLE; Cosmic-CLP); Sequence variation: Homozygous for TP53 p.Arg248Gln (c.743G>A) (ClinVar=VCV000012356) (Cosmic-CLP)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Part of: LL-100 blood cancer cell line panel; Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030; Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045
Description: Genome ancestry: African=3.99%; Native American=0%; East Asian, North=4.75%; East Asian, South=0%; South Asian=0%; European, North=49.28%; European, South=41.98% (PubMed=30894373)
Child Cell Lines: CVCL_8811 (NB4-LR1)
CVCL_IY15 (NB4R)
CVCL_U080 (NB4-AsR)
CVCL_U082 (NB4/As)
CVCL_U083 (NB4.007/6)
CVCL_U084 (NB4.306)
CVCL_U085 (NB4-DR1)
CVCL_U086 (NB4-S1)
CVCL_U112 (NB4.437r)
CVCL_VV77 (NB4-A1)
CVCL_VV78 (NB4-B1)
CVCL_VV79 (NB4-D5)
Aliases: NB-4; NB.4
Disease(s): acute promyelocytic leukemia (DOID:0060318) [NCI:C3182,ORDO:520]

References
Additional References at PubMed
PMID:1453773   PMID:1995093   PMID:7630193   PMID:9737686   PMID:11704857   PMID:12353268   PMID:14504097   PMID:15843827   PMID:16408098   PMID:22460905   PMID:23325432   PMID:23955599  
PMID:25894527   PMID:25984343   PMID:27397505   PMID:30285677   PMID:30894373   PMID:31068700   PMID:31160637  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-7721 CELLOSAURUS
  E-MTAB-7722 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
BioSample SAMN03470835 CELLOSAURUS
  SAMN10988571 CELLOSAURUS
BTO BTO_0002136 CELLOSAURUS
Cell Line Ontology CLO_0007947 CELLOSAURUS
Cell Model Passports SIDM00428 CELLOSAURUS
Cellosaurus CVCL_0005 CELLOSAURUS
ChEMBL-Cells CHEMBL3308423 CELLOSAURUS
ChEMBL-Targets CHEMBL614188 CELLOSAURUS
COSMIC Samples 1012107 CELLOSAURUS
  1037664 CELLOSAURUS
  1070692 CELLOSAURUS
  1078721 CELLOSAURUS
  1089522 CELLOSAURUS
  1127257 CELLOSAURUS
  1181601 CELLOSAURUS
  1523826 CELLOSAURUS
  1524838 CELLOSAURUS
  1601063 CELLOSAURUS
  1604862 CELLOSAURUS
  1779130 CELLOSAURUS
  2036677 CELLOSAURUS
  2089653 CELLOSAURUS
  2131548 CELLOSAURUS
  2306227 CELLOSAURUS
  2579202 CELLOSAURUS
  787463 CELLOSAURUS
  850391 CELLOSAURUS
  922661 CELLOSAURUS
  924050 CELLOSAURUS
  975285 CELLOSAURUS
  981582 CELLOSAURUS
  996313 CELLOSAURUS
Cosmic-CLP 1323913 CELLOSAURUS
DepMap ACH-000294 CELLOSAURUS
DOI 10.1016/B978-0-12-221970-2.50457-5 CELLOSAURUS
DSMZ ACC-207 CELLOSAURUS
EFO EFO_0002798 CELLOSAURUS
ENCODE ENCBS032SIL CELLOSAURUS
  ENCBS259AAA CELLOSAURUS
  ENCBS390ENC CELLOSAURUS
GDSC 1323913 CELLOSAURUS
GEO GSM1374696 CELLOSAURUS
  GSM1374697 CELLOSAURUS
  GSM1446740 CELLOSAURUS
  GSM1670151 CELLOSAURUS
  GSM236798 CELLOSAURUS
  GSM236834 CELLOSAURUS
  GSM472929 CELLOSAURUS
  GSM510512 CELLOSAURUS
  GSM510513 CELLOSAURUS
  GSM887349 CELLOSAURUS
  GSM888426 CELLOSAURUS
  GSM945252 CELLOSAURUS
  GSM945275 CELLOSAURUS
LiGeA CCLE_910 CELLOSAURUS
LINCS_LDP LCL-1084 CELLOSAURUS
Lonza 749 CELLOSAURUS
NCIt C3182 CELLOSAURUS
Orphanet 520 CELLOSAURUS
PharmacoDB NB4_990_2019 CELLOSAURUS
PRIDE PXD000589 CELLOSAURUS
  PXD001610 CELLOSAURUS
Progenetix CVCL_0005 CELLOSAURUS
Wikidata Q54907527 CELLOSAURUS