Cell Line : CVCL_0005 (NB4) Homo sapiens
Symbol:	CVCL_0005
Name:	NB4
RGD ID:	21113449
Cell Line Type:	cancer cell line
Origin:	Population: Caucasian; Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Gender:	Female
Research Use:	Omics: Cell surface proteome; Omics: CTCF ChIP-seq epigenome analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep quantitative proteome analysis; Omics: DNA methylation analysis; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis by microarray; Omics: Transcriptome analysis by RNAseq
Phenotype:	Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ=ACC-207); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration:	Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=12353268; PubMed=15843827); Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (Cosmic-CLP; DepMap); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (Cosmic-CLP)
Groups:	Group: Patented cell line; Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE); Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Part of: LL-100 blood cancer cell line panel; Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030; Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045
Description:	HLA typing: A*11:01,11:01; B*35:01,40:01; C*03:04,04:01 (PubMed=26589293); HLA typing: A*11:01:01; B*35:01:01,40:01:02; C*03:04:01,04:01:01; DPB1*01:01:01,04:01:01; DQA1*01:01,03:01:01; DQB1*03:02,05:01:01; DRB1*01:01:01,04:04:01 (CLS=300299); HLA typing: A*11:01:01,11:01:01; B*35:01:01,40:01:02; C*03:04:01,04:01:01 (DSMZCellDive=ACC-207); Genome ancestry: African=3.99%; Native American=0%; East Asian, North=4.75%; East Asian, South=0%; South Asian=0%; European, North=49.28%; European, South=41.98% (PubMed=30894373)
Child Cell Lines:	CVCL_8811 (NB4-LR1) CVCL_IY15 (NB4R) CVCL_U080 (NB4-AsR) CVCL_U082 (NB4/As) CVCL_U083 (NB4.007/6) CVCL_U084 (NB4.306) CVCL_U085 (NB4-DR1) CVCL_U086 (NB4-S1) CVCL_U112 (NB4.437r) CVCL_VV77 (NB4-A1) CVCL_VV78 (NB4-B1) CVCL_VV79 (NB4-D5)
Aliases:	NB-4; NB.4
Disease(s):	acute promyelocytic leukemia (DOID:0060318) [NCI:C3182,ORDO:520]

Additional References at PubMed

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PMID:1453773	PMID:1995093	PMID:7630193	PMID:9737686	PMID:11704857	PMID:12353268	PMID:14504097	PMID:15843827	PMID:16408098	PMID:22460905	PMID:23325432	PMID:23955599
PMID:25877200	PMID:25894527	PMID:25984343	PMID:26589293	PMID:27397505	PMID:30285677	PMID:30629668	PMID:30894373	PMID:31068700	PMID:31160637	PMID:35839778

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External Database Links

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Database	Acc Id	Source(s)
ArrayExpress	E-MTAB-2770	CELLOSAURUS
	E-MTAB-3610	CELLOSAURUS
	E-MTAB-7721	CELLOSAURUS
	E-MTAB-7722	CELLOSAURUS
	E-MTAB-783	CELLOSAURUS
BioGRID_ORCS_Cell_line	212	CELLOSAURUS
BioSample	SAMN03470835	CELLOSAURUS
	SAMN10988571	CELLOSAURUS
BTO	BTO_0002136	CELLOSAURUS
cancercelllines	CVCL_0005	CELLOSAURUS
Cell Line Ontology	CLO_0007947	CELLOSAURUS
Cell Model Passports	SIDM00428	CELLOSAURUS
Cellosaurus	CVCL_0005	CELLOSAURUS
ChEMBL-Cells	CHEMBL3308423	CELLOSAURUS
ChEMBL-Targets	CHEMBL614188	CELLOSAURUS
COSMIC Samples	1012107	CELLOSAURUS
	1037664	CELLOSAURUS
	1070692	CELLOSAURUS
	1078721	CELLOSAURUS
	1089522	CELLOSAURUS
	1127257	CELLOSAURUS
	1181601	CELLOSAURUS
	1523826	CELLOSAURUS
	1524838	CELLOSAURUS
	1601063	CELLOSAURUS
	1604862	CELLOSAURUS
	1779130	CELLOSAURUS
	2036677	CELLOSAURUS
	2089653	CELLOSAURUS
	2131548	CELLOSAURUS
	2306227	CELLOSAURUS
	2579202	CELLOSAURUS
	787463	CELLOSAURUS
	850391	CELLOSAURUS
	922661	CELLOSAURUS
	924050	CELLOSAURUS
	975285	CELLOSAURUS
	981582	CELLOSAURUS
	996313	CELLOSAURUS
Cosmic-CLP	1323913	CELLOSAURUS
DepMap	ACH-000294	CELLOSAURUS
DOI	10.1016/B978-0-12-221970-2.50457-5	CELLOSAURUS
DSMZ	ACC-207	CELLOSAURUS
DSMZCellDive	ACC-207	CELLOSAURUS
EFO	EFO_0002798	CELLOSAURUS
EGA	EGAS00001000978	CELLOSAURUS
ENCODE	ENCBS032SIL	CELLOSAURUS
	ENCBS259AAA	CELLOSAURUS
	ENCBS390ENC	CELLOSAURUS
GDSC	1323913	CELLOSAURUS
GEO	GSM1022643	CELLOSAURUS
	GSM1374696	CELLOSAURUS
	GSM1374697	CELLOSAURUS
	GSM1446740	CELLOSAURUS
	GSM1670151	CELLOSAURUS
	GSM236798	CELLOSAURUS
	GSM236834	CELLOSAURUS
	GSM472929	CELLOSAURUS
	GSM510512	CELLOSAURUS
	GSM510513	CELLOSAURUS
	GSM749716	CELLOSAURUS
	GSM887349	CELLOSAURUS
	GSM888426	CELLOSAURUS
	GSM945252	CELLOSAURUS
	GSM945275	CELLOSAURUS
LiGeA	CCLE_910	CELLOSAURUS
LINCS_LDP	LCL-1084	CELLOSAURUS
Lonza	749	CELLOSAURUS
NCIt	C3182	CELLOSAURUS
Orphanet	520	CELLOSAURUS
PharmacoDB	NB4_990_2019	CELLOSAURUS
PRIDE	PXD000589	CELLOSAURUS
	PXD001610	CELLOSAURUS
	PXD030304	CELLOSAURUS
Progenetix	CVCL_0005	CELLOSAURUS
Ubigene	YC-C122	CELLOSAURUS
Wikidata	Q54907527	CELLOSAURUS

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