CVCL_0006 - Rat Genome Database

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Cell Line : CVCL_0006 (THP-1) Homo sapiens

Symbol: CVCL_0006
Name: THP-1
RGD ID: 21113448
Cell Line Type: cancer cell line
Origin: Population: Japanese; Derived from sampling site: Peripheral blood.
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep promoter analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Glycoproteome analysis by proteomics; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA
Phenotype: Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Gene fusion; CSNK2A1-DDX39B (PubMed=31160637); Sequence variation: Gene fusion; KMT2A-MLLT3 (MLL-MLLT3; MLL-AF9) (PubMed=11066077; PubMed=15843827); Sequence variation: Heterozygous for NRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000039648) (PubMed=12068308; ATCC; CCLE; Cosmic-CLP); Sequence variation: Heterozygous for TP53 p.Arg174fs*3 (c.520_545del26) (PubMed=1571549; CCLE)
Caution: Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676
Groups: Group: Space-flown cell line (cellonaut); Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: LL-100 blood cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: RAS genetic alteration cell panel (ATCC TCP-1031); Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981)
Description: HLA typing: A*02; B*15:11; C*03; DQB1*05,06; DRB1*01,15; DRB5*01/02 (PubMed=22674354); Genome ancestry: African=0%; Native American=0.3%; East Asian, North=77.63%; East Asian, South=20.4%; South Asian=1.67%; European, North=0%; European, South=0% (PubMed=30894373)
Notes: Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=352912)
Child Cell Lines: CVCL_0R21 (THP-1/DC-SIGN)
CVCL_0R25 (THP-1(NCI))
CVCL_3426 (THP-1h)
CVCL_3427 (THP-1l)
CVCL_4V22 (THP-1/ara-C)
CVCL_5115 (A-THP-1)
CVCL_5I76 (THP1-defCASP1)
CVCL_5I77 (THP1-NLRC4)
CVCL_A1RT (THP-1/E)
CVCL_A4CA (THP-1 AP1-Luc2)
CVCL_A4CB (THP-1 CRE-Luc2)
CVCL_A4CC (THP-1 ISRE-Luc2)
CVCL_A4CD (THP-1 GAS-Luc2)
CVCL_A4CE (THP-1 NF-kB-Luc2)
CVCL_DF52 (THP-1 NucLight Red)
CVCL_IR08 (PSC-THP1)
CVCL_KB46 (CellSensor NFkB-bla THP-1)
CVCL_KS29 (CellSensor SIE-bla THP-1)
CVCL_KS30 (CellSensor TNFalpha-bla THP-1)
CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation)
CVCL_WI26 (THP-1/AR)
CVCL_X582 (THP1-Xblue)
CVCL_X585 (THP1-Blue NF-kappaB)
CVCL_X587 (THP1-Lucia ISG)
CVCL_X588 (THP1-Blue ISG)
CVCL_X589 (THP1-Blue ISG-KD-STING)
CVCL_X590 (THP1-Lucia NF-kappaB)
CVCL_X598 (THP1-defASC)
CVCL_X599 (THP1-Dual)
CVCL_X600 (THP1-defNLRP3)
CVCL_X601 (THP1-Null)
CVCL_X687 (BF24)
CVCL_XD94 (THP-1/IL15)
CVCL_XD95 (THP-1/IL21)
CVCL_XI47 (THP-1 TLR9 mCherry)
CVCL_XZ65 (THP-1 NF-kb luciferase reporter)
Aliases: O-THP-1; THP 1; THP-1(ATCC); THP1; THPI; Tohoku Hospital Pediatrics-1

References
Additional References at PubMed
PMID:1571549   PMID:1915666   PMID:2633408   PMID:6091813   PMID:6970727   PMID:8558913   PMID:9290701   PMID:9379676   PMID:9510473   PMID:9738977   PMID:10223614   PMID:11066077  
PMID:11414198   PMID:12068308   PMID:14504097   PMID:14671638   PMID:15843827   PMID:16408098   PMID:19377474   PMID:20215515   PMID:22460905   PMID:22481983   PMID:22645513   PMID:22674354  
PMID:23097634   PMID:23955599   PMID:24368162   PMID:25130606   PMID:25485619   PMID:25984343   PMID:26421875   PMID:27397505   PMID:28109323   PMID:28196595   PMID:28404994   PMID:30285677  
PMID:30894373   PMID:31068700   PMID:31160637   PMID:31978347  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
  E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-38 CELLOSAURUS
  E-MTAB-7721 CELLOSAURUS
  E-MTAB-7722 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
ATCC TIB-202 CELLOSAURUS
BCRC 60430 CELLOSAURUS
BCRJ 0234 CELLOSAURUS
BioSample SAMN03470795 CELLOSAURUS
  SAMN03473256 CELLOSAURUS
  SAMN03473419 CELLOSAURUS
  SAMN10987847 CELLOSAURUS
BTO BTO_0001370 CELLOSAURUS
CCRID 3111C0001CCC000057 CELLOSAURUS
  3111C0002000000058 CELLOSAURUS
  3131C0001000700057 CELLOSAURUS
  3142C0001000000114 CELLOSAURUS
Cell Line Ontology CLO_0009348 CELLOSAURUS
  CLO_0050999 CELLOSAURUS
Cell Model Passports SIDM01172 CELLOSAURUS
Cellosaurus CVCL_0006 CELLOSAURUS
ChEMBL-Cells CHEMBL3307574 CELLOSAURUS
ChEMBL-Targets CHEMBL614245 CELLOSAURUS
COSMIC Samples 1012124 CELLOSAURUS
  1037666 CELLOSAURUS
  1070694 CELLOSAURUS
  1078722 CELLOSAURUS
  1089517 CELLOSAURUS
  1150901 CELLOSAURUS
  1176587 CELLOSAURUS
  1181604 CELLOSAURUS
  1187864 CELLOSAURUS
  1197931 CELLOSAURUS
  1278779 CELLOSAURUS
  1281356 CELLOSAURUS
  1319551 CELLOSAURUS
  1476425 CELLOSAURUS
  1519163 CELLOSAURUS
  1524842 CELLOSAURUS
  1601064 CELLOSAURUS
  1604863 CELLOSAURUS
  2089655 CELLOSAURUS
  2131559 CELLOSAURUS
  2306241 CELLOSAURUS
  2392976 CELLOSAURUS
  717684 CELLOSAURUS
  724818 CELLOSAURUS
  787480 CELLOSAURUS
  909771 CELLOSAURUS
  919122 CELLOSAURUS
  924051 CELLOSAURUS
  947361 CELLOSAURUS
  975303 CELLOSAURUS
  991556 CELLOSAURUS
  996316 CELLOSAURUS
  998748 CELLOSAURUS
Cosmic-CLP 909771 CELLOSAURUS
DepMap ACH-000146 CELLOSAURUS
DOI 10.1016/B978-0-12-221970-2.50457-5 CELLOSAURUS
DSMZ ACC-16 CELLOSAURUS
EAGLE-I hawaii.eagle-i.net/i/0000012b-5668-8366-2f73-b43980000000 CELLOSAURUS
ECACC 88081201 CELLOSAURUS
EFO EFO_0001253 CELLOSAURUS
ENCODE ENCBS248PAQ CELLOSAURUS
  ENCBS443IYN CELLOSAURUS
  ENCBS461BPB CELLOSAURUS
  ENCBS615XLU CELLOSAURUS
  ENCBS913QYS CELLOSAURUS
  ENCBS980LBL CELLOSAURUS
GDSC 909771 CELLOSAURUS
GEO GSM1374962 CELLOSAURUS
  GSM1446742 CELLOSAURUS
  GSM1670543 CELLOSAURUS
  GSM2141952 CELLOSAURUS
  GSM2141956 CELLOSAURUS
  GSM2141958 CELLOSAURUS
  GSM2141959 CELLOSAURUS
  GSM2141962 CELLOSAURUS
  GSM2141968 CELLOSAURUS
  GSM2141972 CELLOSAURUS
  GSM2141974 CELLOSAURUS
  GSM2141979 CELLOSAURUS
  GSM2141986 CELLOSAURUS
  GSM2141987 CELLOSAURUS
  GSM2141993 CELLOSAURUS
  GSM2141995 CELLOSAURUS
  GSM2141998 CELLOSAURUS
  GSM2141999 CELLOSAURUS
  GSM2142000 CELLOSAURUS
  GSM2142004 CELLOSAURUS
  GSM2142005 CELLOSAURUS
  GSM2142009 CELLOSAURUS
  GSM2142011 CELLOSAURUS
  GSM2142015 CELLOSAURUS
  GSM2142016 CELLOSAURUS
  GSM2142019 CELLOSAURUS
  GSM2142021 CELLOSAURUS
  GSM2142023 CELLOSAURUS
  GSM2142024 CELLOSAURUS
  GSM2142028 CELLOSAURUS
  GSM2142029 CELLOSAURUS
  GSM2142030 CELLOSAURUS
  GSM2142031 CELLOSAURUS
  GSM2142036 CELLOSAURUS
  GSM2142037 CELLOSAURUS
  GSM2142039 CELLOSAURUS
  GSM2142048 CELLOSAURUS
  GSM2142049 CELLOSAURUS
  GSM2142052 CELLOSAURUS
  GSM2142053 CELLOSAURUS
  GSM2142055 CELLOSAURUS
  GSM2142059 CELLOSAURUS
  GSM2142060 CELLOSAURUS
  GSM236807 CELLOSAURUS
  GSM236843 CELLOSAURUS
  GSM482495 CELLOSAURUS
  GSM887706 CELLOSAURUS
  GSM888799 CELLOSAURUS
ICLC HTL97014 CELLOSAURUS
IGRhCellID THP1 CELLOSAURUS
JCRB JCRB0112 CELLOSAURUS
  JCRB0112.1 CELLOSAURUS
KCLB 40202 CELLOSAURUS
LiGeA CCLE_181 CELLOSAURUS
LINCS_HMS 50861 CELLOSAURUS
LINCS_LDP LCL-1072 CELLOSAURUS
Lonza 134 CELLOSAURUS
MESH D000074084 CELLOSAURUS
NCIt C9163 CELLOSAURUS
Orphanet 514 CELLOSAURUS
PharmacoDB THP1_1593_2019 CELLOSAURUS
PRIDE PRD000345 CELLOSAURUS
  PXD000328 CELLOSAURUS
  PXD000953 CELLOSAURUS
  PXD004034 CELLOSAURUS
  PXD008516 CELLOSAURUS
  PXD011690 CELLOSAURUS
Progenetix CVCL_0006 CELLOSAURUS
RCB RCB1189 CELLOSAURUS
  RCB3686 CELLOSAURUS
Wikidata Q7670282 CELLOSAURUS