CVCL_0025 - Rat Genome Database

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Cell Line : CVCL_0025 (Caco-2) Homo sapiens

Symbol: CVCL_0025
Name: Caco-2
RGD ID: 21113383
Cell Line Type: cancer cell line
Origin: Population: Caucasian; Derived from sampling site: Colon.
Gender: Male
Research Use: Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep phosphoproteome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: H3K4me3 ChIP-seq epigenome analysis; Omics: H3K27me3 ChIP-seq epigenome analysis; Omics: H3K36me3 ChIP-seq epigenome analysis; Omics: miRNA expression profiling; Omics: N-glycan profiling; Omics: Protein expression by reverse-phase protein arrays; Omics: SNP array analysis; Omics: Transcriptome analysis
Characteristics: Characteristics: Highly permissive to SARS coronavirus (SARS-Cov) infection (PubMed=15316659)
Phenotype: Doubling time: ~80 hours (DSMZ); ~32 hours (PBCF); ~60-70 hours (CLS); Microsatellite instability: Stable (MSS) (PubMed=24042735; PubMed=25926053; PubMed=28683746)
Genomic Alteration: Sequence variation: Homozygous for APC p.Gln1367Ter (c.4099C>T) (ClinVar=VCV000376060) (PubMed=24755471; CCLE); Sequence variation: Heterozygous for CTNNB1 p.Gly245Ala (c.734G>C) (PubMed=9294210); Sequence variation: Homozygous for SMAD4 p.Asp351His (c.1051G>C) (ClinVar=VCV000375998) (PubMed=24755471; CCLE); Sequence variation: Homozygous for TP53 p.Glu204Ter (c.610G>T) (ClinVar=VCV000977783) (PubMed=16418264; PubMed=24755471; PubMed=28683746; CCLE)
Groups: Part of: AstraZeneca Colorectal cell line (AZCL) panel; Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: ENCODE project common cell types; tier 3; Part of: MD Anderson Cell Lines Project
Description: HLA typing: A*02:01,02:01; B*15:05,56/39; C*04:01,04:01 (PubMed=25960936); Genome ancestry: African=3.33%; Native American=0%; East Asian, North=4.59%; East Asian, South=0%; South Asian=0%; European, North=47.35%; European, South=44.73% (PubMed=30894373)
Child Cell Lines: CVCL_0232 (Caco-2/15)
CVCL_0233 (Caco-2/TC-7)
CVCL_1096 (C2BBe1)
CVCL_HA82 (Caco-2-RCAr clone 2)
CVCL_YP11 (Caco-2 Cu Pro-R)
CVCL_YP12 (Caco-2 CuSO4-R)
CVCL_Z578 (Caco-2/3)
CVCL_Z579 (Caco-2/PD-10)
CVCL_Z580 (Caco-2/PD-7)
CVCL_Z581 (Caco-2/PF-11)
CVCL_Z582 (C2BBe2)
Aliases: Caco 2; CaCo-2; Caco-2/ATCC; Caco-II; CACO2
Disease(s): colon adenocarcinoma (DOID:234) [NCI:C4349]

References
Additional References at PubMed
PMID:327080   PMID:833871   PMID:2914637   PMID:3349466   PMID:3518877   PMID:6935474   PMID:7459858   PMID:9294210   PMID:10612807   PMID:10737795   PMID:11414198   PMID:12584437  
PMID:14599474   PMID:15316659   PMID:15868485   PMID:16418264   PMID:16854228   PMID:18258742   PMID:20570890   PMID:20606684   PMID:20831567   PMID:21607810   PMID:23272949   PMID:23932154  
PMID:24042735   PMID:24755471   PMID:25485619   PMID:25841592   PMID:25926053   PMID:25960936   PMID:26537799   PMID:26869432   PMID:28196595   PMID:28683746   PMID:29101300   PMID:30894373  
PMID:31068700   PMID:31981602  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
ATCC HTB-37 CELLOSAURUS
BCRJ 0059 CELLOSAURUS
BioSample SAMN03473140 CELLOSAURUS
  SAMN05292461 CELLOSAURUS
  SAMN10989600 CELLOSAURUS
BTO BTO_0000195 CELLOSAURUS
CCRID 3111C0001CCC000100 CELLOSAURUS
  3111C0002000000087 CELLOSAURUS
  3131C0001000700066 CELLOSAURUS
  3131C0001000700146 CELLOSAURUS
  3142C0001000000137 CELLOSAURUS
  3153C0001000000219 CELLOSAURUS
Cell Line Ontology CLO_0002172 CELLOSAURUS
  CLO_0050627 CELLOSAURUS
Cell Model Passports SIDM00891 CELLOSAURUS
Cellosaurus CVCL_0025 CELLOSAURUS
ChEMBL-Cells CHEMBL3307519 CELLOSAURUS
ChEMBL-Targets CHEMBL614058 CELLOSAURUS
COSMIC Samples 1043805 CELLOSAURUS
  1122320 CELLOSAURUS
  1132564 CELLOSAURUS
  1132694 CELLOSAURUS
  1184081 CELLOSAURUS
  1187299 CELLOSAURUS
  1310931 CELLOSAURUS
  1466811 CELLOSAURUS
  1479620 CELLOSAURUS
  1524334 CELLOSAURUS
  1552180 CELLOSAURUS
  1676742 CELLOSAURUS
  1708415 CELLOSAURUS
  1803940 CELLOSAURUS
  1933015 CELLOSAURUS
  2036652 CELLOSAURUS
  2145574 CELLOSAURUS
  2156940 CELLOSAURUS
  2301543 CELLOSAURUS
  2301964 CELLOSAURUS
  2667879 CELLOSAURUS
  2800568 CELLOSAURUS
  720340 CELLOSAURUS
  873696 CELLOSAURUS
  875297 CELLOSAURUS
  876709 CELLOSAURUS
  887244 CELLOSAURUS
  889531 CELLOSAURUS
  948127 CELLOSAURUS
  948829 CELLOSAURUS
  983736 CELLOSAURUS
  995392 CELLOSAURUS
DepMap ACH-000003 CELLOSAURUS
DSMZ ACC-169 CELLOSAURUS
ECACC 09042001 CELLOSAURUS
  86010202 CELLOSAURUS
EFO EFO_0001099 CELLOSAURUS
ENCODE ENCBS311PHE CELLOSAURUS
  ENCBS390JMI CELLOSAURUS
  ENCBS391ENC CELLOSAURUS
  ENCBS530YXL CELLOSAURUS
  ENCBS700RKG CELLOSAURUS
  ENCBS890JZY CELLOSAURUS
GEO GSM1006210 CELLOSAURUS
  GSM1006211 CELLOSAURUS
  GSM1006212 CELLOSAURUS
  GSM1346866 CELLOSAURUS
  GSM1374426 CELLOSAURUS
  GSM1448160 CELLOSAURUS
  GSM206450 CELLOSAURUS
  GSM2549989 CELLOSAURUS
  GSM274711 CELLOSAURUS
  GSM274712 CELLOSAURUS
  GSM274725 CELLOSAURUS
  GSM472900 CELLOSAURUS
  GSM472933 CELLOSAURUS
  GSM513908 CELLOSAURUS
  GSM514182 CELLOSAURUS
  GSM741244 CELLOSAURUS
  GSM784006 CELLOSAURUS
  GSM843481 CELLOSAURUS
  GSM843482 CELLOSAURUS
  GSM845394 CELLOSAURUS
  GSM945162 CELLOSAURUS
  GSM945203 CELLOSAURUS
  GSM945206 CELLOSAURUS
  GSM945236 CELLOSAURUS
ICLC HTL97023 CELLOSAURUS
KCLB 30037.1 CELLOSAURUS
LINCS_LDP LCL-1170 CELLOSAURUS
Lonza 36 CELLOSAURUS
MESH D018938 CELLOSAURUS
MetaboLights MTBLS227 CELLOSAURUS
  MTBLS328 CELLOSAURUS
NCIt C4349 CELLOSAURUS
PharmacoDB Caco2_161_2019 CELLOSAURUS
PRIDE PXD001550 CELLOSAURUS
  PXD005354 CELLOSAURUS
  PXD018357 CELLOSAURUS
Progenetix CVCL_0025 CELLOSAURUS
RCB RCB0988 CELLOSAURUS
Wikidata Q5016050 CELLOSAURUS