CVCL_0021 - Rat Genome Database

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Cell Line : CVCL_0021 (U-251MG) Homo sapiens

Symbol: CVCL_0021
Name: U-251MG
RGD ID: 21113379
Cell Line Type: cancer cell line
Origin: Derived from sampling site: Brain; parietal lobe.
Gender: Male
Research Use: Omics: Array-based CGH; Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Fluorescence phenotype profiling; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: Protein expression by reverse-phase protein arrays; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: RCB; RCB0461; true
Phenotype: Doubling time: 24 hours (PubMed=25984343); 23.8 hours (NCI-DTP); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Mutation; IDH1; none detected (PubMed=19435942); Sequence variation: PTEN p.Glu242Valfs*15 (c.723_724dupTG) (ClinVar=VCV000536553) (PubMed=9090379; PubMed=10551321; PubMed=10560660); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (PubMed=31068700); Sequence variation: Homozygous for TP53 p.Arg273His (c.818G>A) (ClinVar=VCV000012366) (PubMed=8878451; PubMed=9614553; PubMed=10416987; PubMed=14614447; PubMed=15900046)
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: JFCR39 cancer cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel
Description: HLA typing: A*02:01:01; B*18; C*05; DPB1*04:02; DQB1*02:01; DRB1*03:01:01 (PubMed=15748285); HLA typing: A*02:01,02:01; B*18:01,18:01; C*05:01,05:01 (PubMed=25960936); Genome ancestry: African=0.69%; Native American=0%; East Asian, North=2.21%; East Asian, South=0%; South Asian=0%; European, North=79.45%; European, South=17.65% (PubMed=30894373)
Child Cell Lines: CVCL_0535 (SNB-19)
CVCL_1G29 (U251-TR3)
CVCL_2219 (U-373MG ATCC)
CVCL_2800 (KNS-89)
CVCL_2809 (U-251MG (KO))
CVCL_2864 (B2-17)
CVCL_5G56 (U-251MG sp)
CVCL_5G63 (U-251MG AgCl1)
CVCL_B325 (TK-1 [Human astrocytoma])
CVCL_J269 (U-251MG-Luc)
Aliases: 251 MG; 251MG; U-251; U-251 MG; U-251-MG; U-251_MG; U251; U251-MG; U251MG; U251n
Disease(s): autosomal dominant cerebellar ataxia (DOID:1441) [ORDO:94]
malignant astrocytoma (DOID:3069) [NCI:C60781]

References
Additional References at PubMed
PMID:450131   PMID:608846   PMID:833871   PMID:2041050   PMID:3335022   PMID:3518877   PMID:3675803   PMID:4134536   PMID:4369403   PMID:6260907   PMID:6582512   PMID:7693337  
PMID:7763724   PMID:8104691   PMID:8878451   PMID:9090379   PMID:9220028   PMID:9614553   PMID:10416987   PMID:10551321   PMID:10560660   PMID:10700174   PMID:14614447   PMID:15748285  
PMID:15900046   PMID:16232199   PMID:16391870   PMID:16697959   PMID:17088437   PMID:19372543   PMID:19435942   PMID:20215515   PMID:20593219   PMID:22068913   PMID:22336246   PMID:22384151  
PMID:22460905   PMID:22570425   PMID:22628656   PMID:23856246   PMID:23933261   PMID:24279929   PMID:24670534   PMID:24810477   PMID:25894527   PMID:25960936   PMID:25984343   PMID:27377824  
PMID:27397505   PMID:27582061   PMID:27807467   PMID:28196595   PMID:30894373   PMID:31068700  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
BioSample SAMN10988290 CELLOSAURUS
BTO BTO_0002035 CELLOSAURUS
CCRID 3111C0001CCC000058 CELLOSAURUS
  3131C0001000700058 CELLOSAURUS
  3142C0001000000112 CELLOSAURUS
Cell Line Ontology CLO_0009456 CELLOSAURUS
Cell Model Passports SIDM00111 CELLOSAURUS
Cellosaurus CVCL_0021 CELLOSAURUS
ChEMBL-Cells CHEMBL3307756 CELLOSAURUS
ChEMBL-Targets CHEMBL615022 CELLOSAURUS
COSMIC Samples 1044250 CELLOSAURUS
  1066235 CELLOSAURUS
  1092644 CELLOSAURUS
  1171225 CELLOSAURUS
  1175823 CELLOSAURUS
  1217673 CELLOSAURUS
  1312345 CELLOSAURUS
  1436038 CELLOSAURUS
  1610741 CELLOSAURUS
  1998487 CELLOSAURUS
  2367502 CELLOSAURUS
  2367554 CELLOSAURUS
  2516042 CELLOSAURUS
  2550363 CELLOSAURUS
  2580916 CELLOSAURUS
  687451 CELLOSAURUS
  848340 CELLOSAURUS
  849850 CELLOSAURUS
  850742 CELLOSAURUS
  875896 CELLOSAURUS
  897440 CELLOSAURUS
  905983 CELLOSAURUS
  920818 CELLOSAURUS
  923899 CELLOSAURUS
  970094 CELLOSAURUS
  974243 CELLOSAURUS
Cosmic-CLP 905983 CELLOSAURUS
DepMap ACH-000232 CELLOSAURUS
DOI 10.1007/0-306-46861-1_11 CELLOSAURUS
  10.1007/978-1-4757-1647-4_7 CELLOSAURUS
  10.1016/B978-0-12-333530-2.50005-8 CELLOSAURUS
ECACC 09063001 CELLOSAURUS
EFO EFO_0006498 CELLOSAURUS
GDSC 905983 CELLOSAURUS
GEO GSE66597 CELLOSAURUS
  GSM101675 CELLOSAURUS
  GSM101677 CELLOSAURUS
  GSM101678 CELLOSAURUS
  GSM101679 CELLOSAURUS
  GSM101680 CELLOSAURUS
  GSM101685 CELLOSAURUS
  GSM1153398 CELLOSAURUS
  GSM1178662 CELLOSAURUS
  GSM1178663 CELLOSAURUS
  GSM1181247 CELLOSAURUS
  GSM1181342 CELLOSAURUS
  GSM1670555 CELLOSAURUS
  GSM2103 CELLOSAURUS
  GSM2124691 CELLOSAURUS
  GSM50180 CELLOSAURUS
  GSM50244 CELLOSAURUS
  GSM743440 CELLOSAURUS
  GSM750795 CELLOSAURUS
  GSM799328 CELLOSAURUS
  GSM799391 CELLOSAURUS
  GSM844718 CELLOSAURUS
  GSM844719 CELLOSAURUS
  GSM847166 CELLOSAURUS
  GSM887720 CELLOSAURUS
  GSM888814 CELLOSAURUS
ICLC HTL99014 CELLOSAURUS
JCRB IFO50288 CELLOSAURUS
LiGeA CCLE_040 CELLOSAURUS
LINCS_LDP LCL-1400 CELLOSAURUS
Lonza 1007 CELLOSAURUS
  105 CELLOSAURUS
NCIt C60781 CELLOSAURUS
Orphanet 94 CELLOSAURUS
PharmacoDB U251MG_1629_2019 CELLOSAURUS
PRIDE PXD000589 CELLOSAURUS
  PXD005940 CELLOSAURUS
  PXD005942 CELLOSAURUS
Progenetix CVCL_0021 CELLOSAURUS
RCB RCB0461 CELLOSAURUS
Wikidata Q54973550 CELLOSAURUS