CVCL_0022 - Rat Genome Database

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Cell Line : CVCL_0022 (U-87MG ATCC) Homo sapiens

Symbol: CVCL_0022
Name: U-87MG ATCC
RGD ID: 21113378
Cell Line Type: cancer cell line
Gender: Male
Research Use: Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep antibody staining analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Genome sequenced; Omics: HLA class I peptidome analysis by proteomics; Omics: shRNA library screening; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: RCB; RCB0419; true.
Phenotype: Doubling time: 72 hours (PubMed=25984343); ~34 hours (PBCF); Microsatellite instability: Stable (MSS) (Sanger)
Genomic Alteration: Sequence variation: Mutation; IDH1; none detected (PubMed=19435942); Sequence variation: Heterozygous for NF1 p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT) (ClinVar=VCV000420078) (CCLE; Cosmic-CLP); Sequence variation: Homozygous for PTEN c.209+1G>T (ClinVar=VCV000229705); Note=Splice donor mutation (PubMed=9090379; CCLE; Cosmic-CLP); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (PubMed=31068700); Sequence variation: Mutation; TP53; none detected (CCLE; Cosmic-CLP)
Caution: Problematic cell line: Misidentified This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (CVCL_GP63) for the original U-87MG cell line.
Groups: Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00535
Description: HLA typing: A*02:01,02:01; B*44:02,44:02; C*05:01,05:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*15:01,13:07 (PubMed=25960936); HLA typing: A*02:01:01; B*44:02; C*05:01:01 (PubMed=27412690); Genome ancestry: African=0.69%; Native American=0%; East Asian, North=3.92%; East Asian, South=0%; South Asian=0%; European, North=72.18%; European, South=23.21% (PubMed=30894373)
Child Cell Lines: CVCL_3428 (U87/DK)
CVCL_3429 (U87/WT)
CVCL_4V16 (U87-MG/Pt)
CVCL_5J12 (U87 MG-Red-FLuc)
CVCL_5J15 (U-87 MG-luc2)
CVCL_JY78 (U87MG.deltaEGFR)
CVCL_JY80 (U87MG.DY1)
CVCL_JY81 (U87MG.DY2)
CVCL_JY82 (U87MG.DY3)
CVCL_JY83 (U87MG.DY4)
CVCL_JY84 (U87MG.DY5)
CVCL_UE09 (U-87MG ATCC IDH1 p.R132H)
CVCL_UR33 (U-87 MG-Luc2)
CVCL_VL16 (U-87MG/DDP)
CVCL_X626 (U87.CD4)
CVCL_X702 (U87-CD4 Clone 2)
CVCL_XZ66 (U87MG Human EGFR vIII)
Aliases: 87 MG; 87MG; U-87; U-87 MG; U-87-MG; U-87MG; U87; U87 MG; U87-MG; U87MG
Disease(s): glioblastoma (DOID:3068) [NCI:C3058]

References
Additional References at PubMed
PMID:327080   PMID:450131   PMID:833871   PMID:3518877   PMID:7459858   PMID:7763724   PMID:8069455   PMID:9090379   PMID:10074188   PMID:10416987   PMID:10560660   PMID:11414198  
PMID:11966317   PMID:14614447   PMID:16232199   PMID:16697959   PMID:19365568   PMID:19435942   PMID:20126413   PMID:20164919   PMID:20215515   PMID:20587068   PMID:20593219   PMID:21406405  
PMID:22282976   PMID:22460905   PMID:22570425   PMID:23325432   PMID:25894527   PMID:25960936   PMID:25984343   PMID:26496030   PMID:27397505   PMID:27412690   PMID:27582061   PMID:30894373  
PMID:31068700   PMID:31978347  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
ATCC HTB-14 CELLOSAURUS
BCRC 60360 CELLOSAURUS
BCRJ 0241 CELLOSAURUS
BioSample SAMN03472715 CELLOSAURUS
  SAMN03473126 CELLOSAURUS
  SAMN05292456 CELLOSAURUS
  SAMN07710026 CELLOSAURUS
  SAMN07710027 CELLOSAURUS
  SAMN07710028 CELLOSAURUS
  SAMN07710029 CELLOSAURUS
  SAMN07710030 CELLOSAURUS
  SAMN07710031 CELLOSAURUS
  SAMN07710032 CELLOSAURUS
  SAMN10988360 CELLOSAURUS
BTO BTO_0002036 CELLOSAURUS
CCRID 3111C0001CCC000208 CELLOSAURUS
  3131C0001000700138 CELLOSAURUS
Cell Line Ontology CLO_0009463 CELLOSAURUS
  CLO_0009464 CELLOSAURUS
Cell Model Passports SIDM01189 CELLOSAURUS
Cellosaurus CVCL_0022 CELLOSAURUS
ChEMBL-Cells CHEMBL3307575 CELLOSAURUS
ChEMBL-Targets CHEMBL614247 CELLOSAURUS
COSMIC Samples 1036336 CELLOSAURUS
  1064099 CELLOSAURUS
  1066234 CELLOSAURUS
  1171224 CELLOSAURUS
  1175825 CELLOSAURUS
  1198263 CELLOSAURUS
  1217671 CELLOSAURUS
  1219449 CELLOSAURUS
  1237542 CELLOSAURUS
  1294951 CELLOSAURUS
  1610737 CELLOSAURUS
  1746951 CELLOSAURUS
  1945859 CELLOSAURUS
  2302316 CELLOSAURUS
  2367555 CELLOSAURUS
  2491106 CELLOSAURUS
  2516044 CELLOSAURUS
  2550364 CELLOSAURUS
  2568870 CELLOSAURUS
  2580918 CELLOSAURUS
  2701083 CELLOSAURUS
  687590 CELLOSAURUS
  849853 CELLOSAURUS
  850741 CELLOSAURUS
  850822 CELLOSAURUS
  920816 CELLOSAURUS
Cosmic-CLP 687590 CELLOSAURUS
DepMap ACH-000075 CELLOSAURUS
ECACC 89081402 CELLOSAURUS
EFO EFO_0005237 CELLOSAURUS
ENCODE ENCBS424ENC CELLOSAURUS
GDSC 687590 CELLOSAURUS
GEO GSM101676 CELLOSAURUS
  GSM101686 CELLOSAURUS
  GSM101687 CELLOSAURUS
  GSM101688 CELLOSAURUS
  GSM1374974 CELLOSAURUS
  GSM1670559 CELLOSAURUS
  GSM2113436 CELLOSAURUS
  GSM2113437 CELLOSAURUS
  GSM2113438 CELLOSAURUS
  GSM2113439 CELLOSAURUS
  GSM326243 CELLOSAURUS
  GSM481417 CELLOSAURUS
  GSM500897 CELLOSAURUS
  GSM887723 CELLOSAURUS
  GSM888817 CELLOSAURUS
  GSM923437 CELLOSAURUS
ICLC HTL00013 CELLOSAURUS
KCLB 30014 CELLOSAURUS
LiGeA CCLE_552 CELLOSAURUS
LINCS_HMS 50868 CELLOSAURUS
LINCS_LDP LCL-1364 CELLOSAURUS
Lonza 37 CELLOSAURUS
  808 CELLOSAURUS
NCIt C3058 CELLOSAURUS
Orphanet 360 CELLOSAURUS
PharmacoDB U87MG_1623_2019 CELLOSAURUS
PRIDE PXD000589 CELLOSAURUS
  PXD000661 CELLOSAURUS
  PXD001565 CELLOSAURUS
  PXD003790 CELLOSAURUS
Progenetix CVCL_0022 CELLOSAURUS
RCB RCB0419 CELLOSAURUS
Wikidata Q7863603 CELLOSAURUS