CVCL_0062 - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_0062 (MDA-MB-231) Homo sapiens

Symbol: CVCL_0062
Name: MDA-MB-231
RGD ID: 21113348
Cell Line Type: cancer cell line
Origin: Derived from metastatic site: Pleural effusion.
Gender: Female
Research Use: Omics: Array-based CGH; Omics: ATAC-seq; Omics: Cell surface proteome; Omics: CNV analysis; Omics: Deep exome analysis; Omics: Deep proteome analysis; Omics: Deep quantitative proteome analysis; Omics: Deep RNAseq analysis; Omics: DNA methylation analysis; Omics: Exosome proteome analysis; Omics: Fluorescence phenotype profiling; Omics: Glycoproteome analysis by proteomics; Omics: lncRNA expression profiling; Omics: Metabolome analysis; Omics: miRNA expression profiling; Omics: N-glycan profiling; Omics: Protein expression by reverse-phase protein arrays; Omics: Secretome proteome analysis; Omics: SNP array analysis; Omics: Transcriptome analysis
Availability: Discontinued: ATCC; CRL-12532; probable; Discontinued: CLS; 300275; true
Phenotype: Doubling time: 1.3 days (PubMed=9671407); 26.7 hours (PubMed=9815641); 41.9 hours (NCI-DTP); 38 hours (ATCC); ~25-30 hours (DSMZ); ~38 hours (PBCF); 31.43 hours (https://www.synapse.org/#!Synapse:syn2347014); Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger)
Genomic Alteration: Sequence variation: Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (PubMed=17088437; PubMed=19593635; ATCC); Sequence variation: Gene deletion; CDKN2A; Zygosity=Homozygous (PubMed=19593635; ATCC); Sequence variation: Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (PubMed=12068308; PubMed=17088437; PubMed=19593635; ATCC); Sequence variation: TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (PubMed=31068700); Sequence variation: Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (PubMed=15900046; PubMed=16541312; PubMed=17088437; PubMed=18277095; PubMed=28889351; ATCC)
Groups: Group: Triple negative breast cancer (TNBC) cell line; Part of: Cancer Cell Line Encyclopedia (CCLE) project; Part of: COSMIC cell lines project; Part of: ENCODE project common cell types; tier 3; Part of: GrayJW breast cancer cell line panel; Part of: ICBP43 breast cancer cell line panel; Part of: JFCR39 cancer cell line panel; Part of: JFCR45 cancer cell line panel; Part of: KuDOS 95 cell line panel; Part of: MD Anderson Cell Lines Project; Part of: NCI-60 cancer cell line panel; Registration: Chiron Master Culture Collection; CMCC 10583 (CMCC #10583)
Description: HLA typing: A*02:01,02:17; B*40:02,41:01; C*02:02:02,17; DPB1*02:01:02,17:01; DQB1*02:02,03:01:01; DRB1*07:01,13:05 (PubMed=15748285); HLA typing: A*02:17,02:01; B*41:01,40:02; C*17:01,02:02; DQA1*02:01,02:01; DQB1*03:04,03:04; DRB1*13:05,07:01 (PubMed=25960936); Genome ancestry: African=1.95%; Native American=0%; East Asian, North=2.44%; East Asian, South=0%; South Asian=7.42%; European, North=28.16%; European, South=60.03% (PubMed=30894373)
Child Cell Lines: CVCL_1D88 (MDA-MB-231-luc-D3H1)
CVCL_1D91 (MDA-MB-231-tdTomato)
CVCL_4V67 (MDA231-DOX[r])
CVCL_4Y38 (MDA-MB-231 25PACR)
CVCL_4Y39 (MDA-MB-231 50PACR)
CVCL_4Z64 (MDA-MB-231/PacR)
CVCL_4Z65 (MDA-MB-231DR)
CVCL_5J05 (MDA-MB-231-Red-FLuc)
CVCL_5J06 (MDA-MB-231-Red-FLuc-GFP)
CVCL_5T76 (MDA-MB-231/B02)
CVCL_9U30 (MDA-MB-231-5a)
CVCL_D582 (MDA-MB-231-luc2)
CVCL_DF47 (MDA-MB-231 NucLight Green)
CVCL_DF48 (MDA-MB-231 NucLight Red)
CVCL_DP48 (MDA-BoM-1833)
CVCL_EQ20 (2LMP)
CVCL_IN15 (MDA-MB-231 ERalpha203/4/11)
CVCL_IN16 (MDA-MB-231 CMV)
CVCL_IN17 (MDA-MB-231 ERalpha)
CVCL_IN18 (MDA-MB-231 ERbeta)
CVCL_IN19 (MDA-MB-231 ERbetaDBD)
CVCL_JG53 (MDA-MB-231-Luc)
CVCL_JZ03 (MDA-MB-231/GFP)
CVCL_JZ04 (MDA-MB-231/GFP-RFP)
CVCL_JZ05 (MDA-MB-231/Luc)
CVCL_JZ06 (MDA-MB-231/RFP)
CVCL_M354 (MDA-MB-231LLM)
CVCL_R956 (MDA-MB-231-BAG)
CVCL_RA90 (MDA-MB-231 shPARG)
CVCL_S031 (MDA-MB-231 SimpleCell O-GalNAc)
CVCL_S511 (MDA-MB-231/5-FU)
CVCL_UJ21 (MDA-MB-231-Dox)
CVCL_V403 (MDA-MB-231-MEK-R)
CVCL_VR35 (MDA231-TGL)
CVCL_VR67 (MDA-MB-231 VIM RFP)
CVCL_XE60 (MDA-MB-231sci)
CVCL_YA89 (MDA-MB-231T)
CVCL_YJ26 (MDA-MB-231 shWDR12-4)
CVCL_YJ68 (VAMPIRO MDA-MB-231)
CVCL_YJ86 (LINTERNA MDA-MB-231)
CVCL_YZ80 (MDA-MB-231/Luciferase-2A-RFP)
CVCL_ZZ22 (MDA-MB-231 Vb100)
CVCL_ZZ41 (MDA-MB-231/BCRP)
Aliases: MB231; MD Anderson-Metastatic Breast-231; MD-MB-231; MD-MBA-231; MDA MB 231; MDA MB231; MDA-231; MDA-321; MDA-MB 231; MDA-MB231; MDA-MD-231; MDA-MG-231; MDA.MB.231; MDA231; MDA231-BRE; MDA_MB_231; MDAMB-231; MDAMB231
Disease(s): breast adenocarcinoma (DOID:3458) [NCI:C5214]

References
Additional References at PubMed
PMID:730202   PMID:833871   PMID:1000504   PMID:1000505   PMID:1000506   PMID:3335022   PMID:3518877   PMID:4412247   PMID:6582512   PMID:6935474   PMID:7000337   PMID:7272986  
PMID:7459858   PMID:7902062   PMID:8824553   PMID:9670966   PMID:9671407   PMID:9815641   PMID:10700174   PMID:11687795   PMID:11697798   PMID:12068308   PMID:12353263   PMID:12661003  
PMID:12800145   PMID:15677628   PMID:15748285   PMID:15767549   PMID:15900046   PMID:16049480   PMID:16142302   PMID:16397213   PMID:16541312   PMID:17088437   PMID:17157791   PMID:18277095  
PMID:18386134   PMID:18516279   PMID:18714363   PMID:19372543   PMID:19582160   PMID:19593635   PMID:20070913   PMID:20164919   PMID:21378333   PMID:21778573   PMID:22068913   PMID:22336246  
PMID:22384151   PMID:22460905   PMID:22585861   PMID:22628656   PMID:23151021   PMID:23601657   PMID:23856246   PMID:23933261   PMID:24009699   PMID:24094812   PMID:24162158   PMID:24176112  
PMID:24279929   PMID:24670534   PMID:25485619   PMID:25960936   PMID:26055192   PMID:26218769   PMID:26649326   PMID:27331101   PMID:27377824   PMID:27397505   PMID:27807467   PMID:28196595  
PMID:28287265   PMID:28889351   PMID:30894373   PMID:31068700   PMID:31092827   PMID:31978347   PMID:32782317  


Additional Information

Database Acc Id Source(s)
ArrayExpress E-MTAB-2706 CELLOSAURUS
  E-MTAB-2770 CELLOSAURUS
  E-MTAB-3610 CELLOSAURUS
  E-MTAB-783 CELLOSAURUS
  E-TABM-157 CELLOSAURUS
  E-TABM-244 CELLOSAURUS
ATCC CRL-12532 CELLOSAURUS
  CRM-HTB-26 CELLOSAURUS
  HTB-26 CELLOSAURUS
BCRC 60425 CELLOSAURUS
BCRJ 0164 CELLOSAURUS
BioSample SAMN03472205 CELLOSAURUS
  SAMN05292460 CELLOSAURUS
  SAMN07710033 CELLOSAURUS
  SAMN07710034 CELLOSAURUS
  SAMN07710035 CELLOSAURUS
  SAMN07710036 CELLOSAURUS
  SAMN07710037 CELLOSAURUS
  SAMN07710038 CELLOSAURUS
  SAMN07710039 CELLOSAURUS
  SAMN10987764 CELLOSAURUS
BTO BTO_0000815 CELLOSAURUS
CCRID 3111C0001CCC000014 CELLOSAURUS
  3131C0001000700104 CELLOSAURUS
  3142C0001000000323 CELLOSAURUS
  3153C0001000000222 CELLOSAURUS
Cell Line Ontology CLO_0007634 CELLOSAURUS
  CLO_0037291 CELLOSAURUS
Cell Model Passports SIDM00146 CELLOSAURUS
CelloPub CLPUB00423 CELLOSAURUS
Cellosaurus CVCL_0062 CELLOSAURUS
ChEMBL-Cells CHEMBL3307960 CELLOSAURUS
ChEMBL-Targets CHEMBL400 CELLOSAURUS
COSMIC Samples 1010924 CELLOSAURUS
  1018477 CELLOSAURUS
  1027053 CELLOSAURUS
  1044226 CELLOSAURUS
  1046950 CELLOSAURUS
  1047693 CELLOSAURUS
  1071900 CELLOSAURUS
  1092613 CELLOSAURUS
  1136369 CELLOSAURUS
  1152528 CELLOSAURUS
  1175833 CELLOSAURUS
  1176602 CELLOSAURUS
  1176636 CELLOSAURUS
  1183773 CELLOSAURUS
  1219444 CELLOSAURUS
  1287926 CELLOSAURUS
  1289395 CELLOSAURUS
  1305383 CELLOSAURUS
  1309003 CELLOSAURUS
  1312370 CELLOSAURUS
  1434952 CELLOSAURUS
  1436032 CELLOSAURUS
  1466805 CELLOSAURUS
  1477428 CELLOSAURUS
  1481426 CELLOSAURUS
  1524347 CELLOSAURUS
  1571793 CELLOSAURUS
  1609458 CELLOSAURUS
  1927242 CELLOSAURUS
  1945862 CELLOSAURUS
  1998455 CELLOSAURUS
  2009512 CELLOSAURUS
  2036667 CELLOSAURUS
  2164997 CELLOSAURUS
  2301528 CELLOSAURUS
  2318377 CELLOSAURUS
  2361355 CELLOSAURUS
  2560256 CELLOSAURUS
  687494 CELLOSAURUS
  871146 CELLOSAURUS
  875878 CELLOSAURUS
  877450 CELLOSAURUS
  894087 CELLOSAURUS
  897423 CELLOSAURUS
  904377 CELLOSAURUS
  905960 CELLOSAURUS
  934536 CELLOSAURUS
  944294 CELLOSAURUS
  974235 CELLOSAURUS
  991324 CELLOSAURUS
  997929 CELLOSAURUS
Cosmic-CLP 905960 CELLOSAURUS
DepMap ACH-000768 CELLOSAURUS
DOI 10.1016/B978-0-12-333530-2.50009-5 CELLOSAURUS
  10.4172/2157-7145.S2-005 CELLOSAURUS
DSMZ ACC-732 CELLOSAURUS
ECACC 92020424 CELLOSAURUS
EFO EFO_0001209 CELLOSAURUS
GDSC 905960 CELLOSAURUS
GEO GSM1008905 CELLOSAURUS
  GSM1053716 CELLOSAURUS
  GSM1153390 CELLOSAURUS
  GSM1172889 CELLOSAURUS
  GSM1172979 CELLOSAURUS
  GSM1181242 CELLOSAURUS
  GSM1181365 CELLOSAURUS
  GSM1214569 CELLOSAURUS
  GSM1238120 CELLOSAURUS
  GSM1374651 CELLOSAURUS
  GSM1374652 CELLOSAURUS
  GSM1401658 CELLOSAURUS
  GSM155213 CELLOSAURUS
  GSM1613823 CELLOSAURUS
  GSM1670080 CELLOSAURUS
  GSM1833624 CELLOSAURUS
  GSM185093 CELLOSAURUS
  GSM185094 CELLOSAURUS
  GSM2095710 CELLOSAURUS
  GSM2095711 CELLOSAURUS
  GSM2124 CELLOSAURUS
  GSM2124643 CELLOSAURUS
  GSM274653 CELLOSAURUS
  GSM3161720 CELLOSAURUS
  GSM3161721 CELLOSAURUS
  GSM344349 CELLOSAURUS
  GSM344399 CELLOSAURUS
  GSM350547 CELLOSAURUS
  GSM378148 CELLOSAURUS
  GSM388213 CELLOSAURUS
  GSM421873 CELLOSAURUS
  GSM459713 CELLOSAURUS
  GSM481304 CELLOSAURUS
  GSM49953 CELLOSAURUS
  GSM49954 CELLOSAURUS
  GSM50184 CELLOSAURUS
  GSM50248 CELLOSAURUS
  GSM587393 CELLOSAURUS
  GSM587394 CELLOSAURUS
  GSM69194 CELLOSAURUS
  GSM750781 CELLOSAURUS
  GSM799321 CELLOSAURUS
  GSM799384 CELLOSAURUS
  GSM812 CELLOSAURUS
  GSM820814 CELLOSAURUS
  GSM820815 CELLOSAURUS
  GSM820816 CELLOSAURUS
  GSM839034 CELLOSAURUS
  GSM844594 CELLOSAURUS
  GSM844595 CELLOSAURUS
  GSM847036 CELLOSAURUS
  GSM847401 CELLOSAURUS
  GSM887295 CELLOSAURUS
  GSM888370 CELLOSAURUS
  GSM967818 CELLOSAURUS
ICLC HTL99004 CELLOSAURUS
KCLB 30026 CELLOSAURUS
LiGeA CCLE_752 CELLOSAURUS
LINCS_HMS 50058 CELLOSAURUS
LINCS_LDP LCL-1461 CELLOSAURUS
Lonza 815 CELLOSAURUS
MetaboLights MTBLS337 CELLOSAURUS
  MTBLS387 CELLOSAURUS
  MTBLS678 CELLOSAURUS
NCIt C5214 CELLOSAURUS
PharmacoDB MDAMB231_900_2019 CELLOSAURUS
PRIDE PXD000239 CELLOSAURUS
  PXD000397 CELLOSAURUS
  PXD000691 CELLOSAURUS
  PXD000914 CELLOSAURUS
  PXD001553 CELLOSAURUS
  PXD002192 CELLOSAURUS
  PXD002649 CELLOSAURUS
  PXD005292 CELLOSAURUS
  PXD005942 CELLOSAURUS
  PXD010634 CELLOSAURUS
Progenetix CVCL_0062 CELLOSAURUS
Wikidata Q17577870 CELLOSAURUS