CVCL_S031 - Rat Genome Database

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Cell Line : CVCL_S031 (MDA-MB-231 SimpleCell O-GalNAc) Homo sapiens

Symbol: CVCL_S031
Name: MDA-MB-231 SimpleCell O-GalNAc
RGD ID: 21110979
Cell Line Type: cancer cell line
Origin: Population: Caucasian; Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Gender: Female
Characteristics: Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans
Genomic Alteration: Knockout cell: Method=ZFN; HGNC; 24338; C1GALT1C1; Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line); Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line); Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line); Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line)
Groups: Group: Triple negative breast cancer (TNBC) cell line
Related Genes: C1GALT1C1  
Derived From Cell Lines: CVCL_0062 (MDA-MB-231)
Child Cell Lines: CVCL_S032 (MDA-MB-231 SimpleCell O-GalNAC/O-Man)
Aliases: MDA-MB-231 SC; MDA-MB-231 SimpleCell
Disease(s): breast adenocarcinoma (DOID:3458) [NCI:C5214]

References
Additional References at PubMed
PMID:23584533  


Additional Information

Database Acc Id Source(s)
cancercelllines CVCL_S031 CELLOSAURUS
Cellosaurus CVCL_S031 CELLOSAURUS
NCIt C5214 CELLOSAURUS
Wikidata Q54904590 CELLOSAURUS