CVCL_J431 - Rat Genome Database

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Cell Line : CVCL_J431 (RPMI-8226/Dox40) Homo sapiens

Symbol: CVCL_J431
Name: RPMI-8226/Dox40
RGD ID: 21110158
Cell Line Type: cancer cell line
Origin: Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Derived from sampling site: Peripheral blood.
Gender: Male
Characteristics: Characteristics: Produces IgG lambda
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (ClinVar=VCV000177773) (from parent cell line); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (ClinVar=VCV000045122) (from parent cell line); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line); Sequence variation: TRAF3 p.Lys191Leufs*60 (from parent cell line)
Derived From Cell Lines: CVCL_0014 (RPMI-8226)
Child Cell Lines: CVCL_J433 (RPMI-8226/MDR10V)
Aliases: 8226 Dox40; 8226/Dox(40); 8226/DOX40; Dox40; RPMI 8226/DOX40; RPMI-8226DOX40
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

References
Additional References at PubMed
PMID:2569359   PMID:10095106   PMID:10825126   PMID:11309308  


Additional Information

Database Acc Id Source(s)
Cellosaurus CVCL_J431 CELLOSAURUS
NCIt C3242 CELLOSAURUS
Orphanet 29073 CELLOSAURUS
Wikidata Q54951246 CELLOSAURUS