CVCL_J432 - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Cell Line : CVCL_J432 (RPMI-8226/Dox6) Homo sapiens

Symbol: CVCL_J432
Name: RPMI-8226/Dox6
RGD ID: 21110152
Cell Line Type: cancer cell line
Origin: Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Derived from sampling site: Peripheral blood.
Gender: Male
Characteristics: Characteristics: Produces IgG lambda (from parent cell line)
Genomic Alteration: Sequence variation: Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (ClinVar=VCV000177773) (from parent cell line); Sequence variation: Heterozygous for KRAS p.Gly12Ala (c.35G>C) (ClinVar=VCV000045122) (from parent cell line); Sequence variation: Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line); Sequence variation: TRAF3 p.Lys191Leufs*60 (from parent cell line)
Derived From Cell Lines: CVCL_0014 (RPMI-8226)
Aliases: 8226/DOX6; DOX-6; Dox6; RPMI 8226/DOX6
Disease(s): multiple myeloma (DOID:9538) [NCI:C3242,ORDO:29073]

References
Additional References at PubMed
PMID:2569359   PMID:10070958  


Additional Information

Database Acc Id Source(s)
Cellosaurus CVCL_J432 CELLOSAURUS
NCIt C3242 CELLOSAURUS
Orphanet 29073 CELLOSAURUS
Wikidata Q54951247 CELLOSAURUS