CVCL_II77 - Rat Genome Database

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Cell Line : CVCL_II77 (HL-60/S4) Homo sapiens

Symbol: CVCL_II77
Name: HL-60/S4
RGD ID: 21106121
Cell Line Type: cancer cell line
Origin: Transformant: N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)(ChEBI; CHEBI:21759); Derived from sampling site: Peripheral blood.
Gender: Female
Research Use: Omics: DNA methylation analysis
Characteristics: Characteristics: Differentiation to a granulocyte-like state can be induced by retinoic acid (RA)
Genomic Alteration: Sequence variation: Homozygous for CDKN2A p.Arg80Ter (c.238C>T) (p.Pro94Leu; c.281C>T) (ClinVar=VCV000009409) (from parent cell line); Sequence variation: Heterozygous for NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (from parent cell line); Sequence variation: Gene deletion; TP53; Zygosity=Homozygous (from parent cell line)
Derived From Cell Lines: CVCL_0002 (HL-60)

References
Additional References at PubMed
PMID:1737356   PMID:31988093  


Additional Information

Database Acc Id Source(s)
ATCC CRL-3306 CELLOSAURUS
Cellosaurus CVCL_II77 CELLOSAURUS
NCIt C9154 CELLOSAURUS
Orphanet 519 CELLOSAURUS
Wikidata Q54889808 CELLOSAURUS